• Bulletin of the Korean Chemical Society
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• 제33권7호
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• pp.2359-2364
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• 2012

Two new chemosensors, rhodamine 6G derivative bearing hydroxyethyl group (1) and rhodamine base derivative bearing 15-crown-5 group (2) were synthesized and their sensing behaviors toward various metal ions were investigated by UV/Vis and fluorescence spectroscopies. Addition of $Hg^{2+}$ ion to a $CH_3CN$ solution of 1 and 2 gave visual color changes as well as fluorescent OFF-ON observations. Selectivity and sensitivity of 1 towards $Hg^{2+}$ are excellent enough to detect micromolar level of $Hg^{2+}$ ion, even in equeous media and biological sample (HeLa cell).

• 대한화학회지
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• 제51권4호
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• pp.324-330
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• 2007

수은(II) 이온 센서로 이온투과 담체로서 bis(benzoylacetone) propylenediimine (H2(BA)2PD)을 근간으로 하는 새로운 이온 선택 PVC 막 전극이 개발하였다. 이 전극은 좋은 감응 특성을 보였고, 29.8±0.75 mV/10의 Nernstian 기울기로 부터 1.0×10-6-1.0×10-1 M 수은(II) 이온 농도 범위에서 선형 Emf vs. log[Hg2+]를 보였다. pH 2.5-11.5에서 검출한계는 2.2×10-7 M Hg(II)를 보였다. 다수의 전위 간섭이온에의 수은(II)이온 대한 선택 농도에 대해 역시 연구되었다. 이 센서는 다른 전하와 함께 많은 수의 양이온에 있어 수은(II)이온에 대해 고선택성을 보였다. 이 센 서는 60초 안에 빠는 감응을 보이며 화학적으로 불활성인 것을 알아 내었고 3개월 동안 좋은 재현성을 보였다(S = 0.27 mV). 이 전극은 실제 시료에서 수은(II)이온 의 분석에 대해 서도 만족할 만한 결과를 얻었다.

• EDISON SW 활용 경진대회 논문집
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• 제3회(2014년)
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• pp.275-285
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• 2014

Dipyrene-based fluorescent chemosensor(분자 1)가 개발되었다. 분자 1은 여러 금속이온 중 $Cu^{2+}$와 $Hg^{2+}$의 fluorescent chemosensor로서 센싱할 수 있고, excimer-switch off mechanism에 따라 $Cu^{2+}$와 $Hg^{2+}$ 금속이온을 감지한다. Ground state와 excited state에 대한 DFT와 TD-DFT 방법을 통해 분자 1의 $Hg^{2+}$에 대한 형광 turn on/off을 확인하고, 구조변화에 따른 molecular orbital을 계산하였다. 계산결과 분자 1은 excited state에서 excimer를 형성할 수 있으나 $1+Hg^{2+}$는 excimer를 형성하지 못함을 알 수 있었다. 여기서 우리는 분자 1과 $Hg^{2+}$ 금속이온 결합에 대하여 실험값과 비교 분석하여 그 메커니즘 조사하였다.

• 센서학회지
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• 제23권6호
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• pp.409-415
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• 2014

We had presented an inductive type intraocular pressure sensor (L-sensor) in previous work. The distance between a micro coil and a ferrite on the membrane was modulated by pressure, and as a result the inductance and resonant frequency were changed. However, L-sensor has some problems to implant in eyes. First problem is low sensitivity. When L-sensor was implanted in rabbit's eyes, resonant frequency of L-sensor was very hard to detect. Second problem is biocompatibility. Size of L-sensor is $6{\times}7{\times}1.2mm$. When L-sensor was implanted in the eyes, it caused the inflammation. Therefore, this study suggests an inductive and capacitive type IOP sensor (LCsensor). The sensitivity of the LC-sensor 27.3 kHz/mmHg under 60mmHg. It is much larger than 14 kHz/mmHg of the L-sensor. And the size of LC-sensor is 47% smaller than L-sensor. After 2 weeks from the implantation of LC-sensor into rabbit eyes, we measured the changes of resonant frequency of LC-sensor according to increased IOP by Balanced Salt Solution (BSS) injection. As a result, the sensitivity of LC-sensor in in vivo test is 25 kHz/mmHg. That is similar to the sensitivity of in vitro test.

• Bulletin of the Korean Chemical Society
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• 제35권11호
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• pp.3326-3330
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• 2014

A quinoline-thiooxorhodamine conjugate fluorescent sensor (1) has been synthesized. Sensor 1 exhibits high selectivity and sensitivity to $Hg^{2+}$ in $H_2O$/DMSO (95/5, v/v, HEPES 20 mM, pH = 7.4) solution with fluorescence detection. Other tested metal ions do not induce any significant fluorescence intensity changes. Sensor 1 interacts with $Hg^{2+}$ through a 1:1 binding stoichiometry with a good anti-inference ability. In addition, fluorescent imaging of $Hg^{2+}$ in Hela cells is also successfully demonstrated.

• 센서학회지
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• 제21권2호
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• pp.121-126
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• 2012

Piezoresistive type contact force sensor array is fabricated by (111) Silicon bulk micromachining for continuous blood pressure monitoring. Length and width of the unit sensor structure is $200{\mu}m$ and $190{\mu}m$, respectively. The gap between sensing elements is only $10{\mu}m$. To achieve wafer level packaging, the sensor structure is capped by PDMS soft cap using wafer molding and bonding process with $10{\mu}m$ alignment precision. The resistance change over contact force was measured to verify the feasibility of the proposed sensor scheme. The maximum measurement range and resolution is 900 mm Hg and 0.57 mm Hg, respectively.

• 한국전기전자재료학회논문지
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• 제26권9호
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• pp.669-676
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• 2013

In this study, we introduce a polymer(polyimide) based pressure sensor to measure real-time heart beat and blood pressure. The sensor have been designed with consideration of skin compatibility of material, cost effectiveness, manufacturability and wireless detection. The designed sensor was composed of inductor coils and an air-gap capacitor which generate self-resonant frequency when electrical source is applied on the system. The sensor was obtained with metalization, etching, photolithography, polymer adhesive bonding and laser cutting. The fabricated sensor was shaped in circular type with 10mm diameter and 0.45 mm thickness to fit radial artery. Resonant frequencies of the fabricated sensors were in the range of 91~96 MHz on 760 mmHg pressurized environment. Also the sensor has good linearity without any pressure-frequency hysteresis. Sensitivity of the sensor was 145.5 kHz/mmHg and accuracy was less than 2 mmHg. Real-time heart beat measurement was executed with a developed hand-held measurement system. Possibility of real-time blood pressure measurement was showed with simulated artery system. After installation of the sensor on skin above radial artery, simple real blood pressure measurement was performed with 64 mmHg blood pressure variation.

• 대한전자공학회논문지
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• 제27권11호
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• pp.62-68
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• 1990

표준 Si 공정기술을 이용하여 칩의 크기가 $1.7{\times}1.7{mm^2}$인 소형 압저항형 Si 압력센서를 제작하고 그 동작 특성을 평가하였다. 제작된 센서는 크기 $1.0{\times}1.0{mm^2}$, 두께 $20{\mu}m$의 n형 Si 다이아프램상에 4개의 붕소 확산저항이 브릿지 형태로 연결된 칩 구조를 가지며 최종적으로 게이지압을 측장할 수 있도록 상온 상압하에서 패키징하였다. 이 센서의 동작특성은 상온에서 압력감도 $14.2{\mu}V/V{\cdot}mmHg$ 정격 압력범위 0~760mmHg, 최대 비선형성 $1.0{\%}$ FS로 평가되었다.

• Bulletin of the Korean Chemical Society
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• 제32권1호
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• pp.338-340
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• 2011

• 한국환경과학회지
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• 제29권2호
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• pp.201-207
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• 2020

A new chemosensor based on a self-assembled system has been devised to detect Hg²⁺ions efficiently. We demonstrated that the amphiphilic building blocks consisting of pyrene and boronic acid (1) aggregate in aqueous solutions and provide an outstanding sensing platform for sensitive detection. The self-assembled 1 exhibited high selectivity and sensitivity for Hg²⁺ion detection via fluorescence quenching, where the Hg²⁺ion detection ensued from a fast transmetallation of 1. The Stern-Volmer (SV) quenching constant for its fluorescence quenching by Hg²⁺ions was approximately 1.58 × 10⁸ M^-1. In addition, self-assembled 1 exhibited excellent sensing abilities at nano-molar concentration levels when tap water and freshwater samples were contaminated with of Hg²⁺ ions.