• Natural Product Sciences
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• v.8 no.2
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• pp.35-43
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• 2002

Glycosides of herbal medicines, such as glycyrrhizin, ginsenosides, kalopanaxsaponins, rutin and ponicirin, were studied regarding their metabolic fates and pharmacological actions in relation to intestinal bacteria using germ-free, gnotobiotic and conventional animals. When glycyrrhizin (GL) was orally administered, $18{\beta}-glycyrrhetinic\;acid\;(GA)$, not GL, was detected in plasma and intestinal contents of gnotobiotic and conventional rats. However, GA could not be detected in germ-free rats. When GL was incubated with human intestinal bacteria, it was directly metabolized to GA (>95%) or via $18{\beta}-glycyrrhetinic\;acid-3-{\beta}-D-glucuronide$(>5%). Orally administered GL was effective in gnotobiotic and conventional rats for liver injury induced by carbon tetrachloride, but was not effective in germ-free rats. When ginseng saponins were orally administered to human beings, compound K in the plasma was detected, but the other protopanxadiol saponins were not detected. The compound K was active for tumor metastasis and allergy. When kalopanaxsaponins were incubated with human intestinal microflora, they were metabolized to kalopanaxsaponin A, kalopanaxsaponin I and hederagenin. These metabolites were active for rheumatoid arthritis and diabetic mellitus while the other kalopanxsaponins were not. When flavonoid glycosides were orally administered to animals, aglycones and/or phenolic acids were detected in the urine. The metabolic pathways proceeded by intestinal bacteria rather than by liver or blood enzymes. These metabolites, aglycones and phenolic acids, showed antitumor, antiinflammatory and antiplatelet aggregation activities. These findings suggest that glycosides of herbal medicines are prodrugs.

• Proceedings of the Korea Information Processing Society Conference
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• 2015.10a
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• pp.1632-1635
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• 2015

발전하는 IT 기술은 사회, 문화, 교육 등 전 산업 분야에 많은 영향을 미치고 있으며, e-book 및 콘텐츠 시장은 여러 산업분야에서 주목받고 있는 중요한 기술개발분야 중에 한 부분이라고 할 수 있다. 하지만 현재까지 e-book의 경우 비 표준화 확장, 단 방향성 비 상호작용, 2차원적인 콘텐츠 사용 등 여러가지 한계적 사용에 문제점을 가지고 있었다. 따라서 본 논문에서는 WebGL 3D 콘텐츠를 이용한 인터렉티브 가상 시뮬레이션 e-book 협업 저작도구를 설계하고 구현하였다. 본 연구에서는 표준화된 HTML5 기술과 IDPF에서 제안된 EPUB3를 통해 기존의 e-book 활용의 한계점들을 극복하고, WebGL 웹 표준 기술을 적용하여 인터렉티브 가상 시뮬레이션 사용이 가능한 전자책 그래픽 요소를 구현 하였다. 향후 본 연구를 통해 표준화된 e-book 콘텐츠 시장의 활성화와 효율적인 교육 도구의 발전을 기대한다.

• 프린팅코리아
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• v.8 no.2
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• pp.86-87
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• 2009

• Korean Journal of Human Ecology
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• v.7 no.3
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• pp.49-58
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• 2004

The purpose of the study was to verify if or not as funtional food by estimating antitumor activity and antimicrobial activity of Coriolus versicolor(Fr.)Quel and Ganoderma Lucidum (Fr.)Karst. 1. The contents of moisture. crude fiber and crude protein of GL were higher $(18.28\%,\;10.3\%,\;78.4\%)$ than that of CV, but the content of crude lipid GL was higher than that of CV. 2. Inhibitory effects of on the growth of AGS human gastric adenocarcinoma cells and HT-29 human colon adenocarcinoma cell were increased by increasing of concentration in added methanol extracts of CV and GL. 3. Antimicrobial activity on Escherichia col1; Staphylococcus aureus, Salmonella typhimurium existed methanol extracts of CV. Therefore. it is suggested that CV is worth as functional food.

• Journal of the Korea Computer Graphics Society
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• v.11 no.2
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• pp.56-63
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• 2005

모바일 환경에서 고급 그래픽스 기술을 적용하고자 하는 시도로 최근 3D 그래픽 엔진을 탑재한 단말기가 출시되고 있다. 이 단말기는 OpenGL ES 1.x 을 기준으로 고정된 파이프라인을 통해 그래픽 연산을 처리하고 있으므로 사용자가 다양한 그래픽 표현을 수행하는데 제약이 따른다. 최근 PC 환경의 그래픽 엔진에서는 고정 기능의 파이프라인이 아닌 프로그래밍 가능한 파이프라인을 제공하여 기존 고정 파이프라인에서 불가능했던 유연한 그래픽스 기술을 제공하고 있다. PC환경의 프로그래밍 가능한 파이프라인은 DirectX 와 OpenGL ARB Extension 그래픽 라이브러리에 의해 제공되고 있지만, 모바일 환경에서는 이를 지원하기 위한 관련 제품이 아직 출시되지 않고 있는 상태이다. 본 논문에서는 OpenGL ARB Extension 1.0 을 근거로 정점 프로세싱 과정을 프로그래밍 가능한 파이프라인 구조로 동작하도록 하는 모바일용 정점 프로그램 가상머신을 제시한다.

• Archives of Pharmacal Research
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• v.27 no.1
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• pp.57-60
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• 2004

Glycyrrhizin (18$\beta$-glycyrrhetinic acid-3-O-$\beta$-D-glucuronopyranosyl-(1$\rightarrow2)-\beta$-D-glucuronide, GL) was transformed to 18$\beta$-glycyrrhetinic acid-3-O-$\beta$-D-glucuronide (GAMG) by Streptococcus LJ-22. The antiallergic activities of GL and GAMG was measured using a RBL cell assay system and contact hypersensitivity model mice. GAMG exhibited anti-allergic activity with $IC_{50}$ values of 0.28 mM. GAMG, which is sweeter than GL, and 18$\beta$-glycyrrhetinic acid, which is a GAMG metabolite by human intestinal bacteria, also inhibited the passive cutaneous anaphylaxis and skin contact inflammation. In conclusion, GAMG may be useful as a new sweet food additive and an anti-allergic agent.

• The Journal of the Korea Contents Association
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• v.8 no.9
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• pp.274-280
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• 2008

The new high order Earth's gravity Model(EGM2008) are expected to improve the application about the Earth's global gravity field. The objectives of this research are to present characteristics on the geoid heights of provinces in South KOREA which calculated from the height anomalies by Earth Gravity Models. For this, seven EGMs (EGM2008<2,190>, EGM2008<360>, EGM96, EIGEN-GL04C, EIGEN-CG03C, EIGEN-GL04S1, and ITG-Grace02S) selected. Geoid heights of fifty BM check points by GPS/levelling are compared with those by NORI-05 model and seven EGMs. And also, geoid heights of 30"$\times$30" grid points in land(sixes blocks ; $1^{\circ}\times1^{\circ}$ sampled) and sea (four blocks ; $1^{\circ}\times1^{\circ}$ sampled) areas of South KOREA by EGM2008 are compared with those by NORI-05 and six EGMs. The results show that geoid heights obtained from EGM2008(2,190) of NGA displayed the nearest results to those by GPS/levelling.

• Journal of Life Science
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• v.29 no.10
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• pp.1159-1163
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• 2019

Although there is a growing interest in male menopause, a phenomenon associated with male hormone depletion, current kits using antibodies to quantify male hormones are expensive. In this study, we constructed an in vitro system for verifying the activity or concentration of male steroid hormones using a transcriptional activity test. A reporter plasmid, pGL2-Neo-ARE-AdE1BTATA, which reacts to testosterone, was constructed. In this plasmid, the ARE-AdE1bTATA sequences can be bounded by the testosterone - androgen receptor complex to express luciferase as a reporter. Then, a stable transfection was performed on the human prostate cancer cell line, LNcap-LN3. The constructed LNcap-LN3/pGL2-Neo-ARE-AdE1BTATA testosterone compound detection (TCD) system showed quantitatively proportional luciferase activities to concentrations of $10^{-13}$ to $10^{-8}M$ of standard testosterone. The established in vitro TCD system will contribute to the development of materials for health/functional foods and drugs as it will be possible to search en masse for testosterone-like or testosterone-inhibiting substances derived from natural materials.

• The KIPS Transactions:PartB
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• v.14B no.6
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• pp.423-430
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• 2007

Optical coherence tomography(OCT) is a high resolution imaging system which can image the cross section of microscopic organs in a living tissue with about $1{\mu}m$ resolution. In this paper, we implement OCT system and acquire 2-D images of rat eye and human molar samples especially in the field of opthalmology and dentistry. In terms of 2-D images, we reconstruct 3-D OCT images which give us another inner structural information of target objects. OPEN-GL reduces the 3-D processing time 10 times less than MATLAB.

• Journal of dental hygiene science
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• v.10 no.6
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• pp.445-450
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• 2010

The aim of this study was to evaluate the effect according to the fiber type and combination on the reinforcement of heat-polymerized denture base resin. The heat-polymerized resin(Vertex RS, Dentimax, Netherlands) was used in this study. Glass fiber(GL; ER 270FW, Hankuk Fiber Glass, Korea), polyaromatic polyamide fiber(PA; aramid; Kevlar-49, Dupont, U.S.A.) and ultra high molecular weight polyethylene fiber(PE, polyethylene; P.E, Dong Yang Rope, Korea) were used to reinforce the denture base resin specimens. The final size of test specimen was $64mm{\times}10mm{\times}3.3mm$. The specimens of each group were stored in distilled water at $37^{\circ}C$ for 50 hours before measurement. The flexural strength and flexural modulus were measured by an universal testing machine(Z020, Zwick, Germany) at a crosshead speed of 5 mm/min in a three-point bending mode. In this study, all fibers showed reinforcing effects on denture base resin(p<0.05). In terms of flexural strength and flexural modulus, glass fiber 5.3 vol.% showed most effective reinforcing effect on heat polymerized denture base resin. For flexural modulus, PA/GL was the highest in denture base resin specimen for hybrid FRC using two combination (p<0.05). Glass fiber 5.3 vol.% and PA/GL are considered to be applied effectively in reinforcing the heat polymerized denture base resin.