• Asian Pacific Journal of Cancer Prevention
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• v.16 no.17
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• pp.7575-7582
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• 2015

Cyclin E, a key coordinator of the G1 to S transition in the cell cycle, may be deregulated in several malignancies, including breast cancer. The most significant aberration in cyclin E is its elastase mediated proteolytic cleavage into tumor specific low molecular weight isoforms (LMW-Es). LMW-Es are biochemically hyperactive and biologically drive tumorigenesis in transgenic mouse models. Additionally, expression of LMW-Es has been correlated with poor survival in breast cancer cases. Here we determine whether expression of LMW-Es in a breast cancer cell line that is naturally devoid of these deregulated forms would alter their progression through each phase of the cell cycle. The results revealed that LMW-Es expression resulted in an increased doubling time, concomitant with a predominant increase in the population in the S phase of the cell cycle. Moreover, downregulation of p53 in LMW-Es cells resulted in additional shortening of the doubling time and enrichment of cells in the S and G2/M phases of the cell cycle. Furthermore, expression of LMW-Es sensitized cells to ${\beta}$-estradiol (E2) mediated growth and changed expression patterns of estrogen receptor and Bcl-2. Intriguingly, expression of LMW-Es could surpass anti-apoptotic effects raised by p53 upregulation. Taken together these studies suggest that overexpression of LMW-Es in collaboration with p53 loss results in altered g rowth properties of MCF-7 cells, enhancing the oncogenic activity of these ER positive breast cancer cells.

• Proceedings of the Korean Society for Cognitive Science Conference
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• 2005.05a
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• pp.23-27
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• 2005

Humans perceptually segment events, but models that predict where events will be segmented are limited. Developing a detailed model may be hard because of the overlapping quality of events (i.e., one can smile and walk at the same time, but the endpoint of each event can be different). However, some aspects of events appear to be universally represented in the world's languages. For example, path, the trajectory of an object's movement, is one of the most universally encoded event features. Although it is generally encoded in the prepositions of English (e.g., up), in other languagesit is encoded in the verbs (e.g., descendere). Linguistic universals may represent basic levels of event perception. Here we consider how one of these, path, might be parsed. Because the spatiotemporal projection of paths to an observation point is similar to the spatial projection of objects, we tested the hypothesis that path segmentation and object segmentation would be based on similar image properties, such as discontinuities in orientation.

• Journal of KIISE:Computer Systems and Theory
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• v.26 no.10
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• pp.1258-1263
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• 1999

본 논문에서는 CRCW(Concurrent Read Concurrent Write)와 CREW(Concurrent Read Exclusive Write) PRAM(Parallel Random Access Machine) 모델에서 무방향성 그래프 G=(V, E)의 극대 매칭을 구하기 위해 간결한 랜덤 병렬 알고리즘을 제안한다. CRCW PRAM 모델에서 m개의 선을 가진 그래프에 대해, 제안된 매칭 알고리즘은 m개의 프로세서 상에서 {{{{ OMICRON (log m)의 기대 수행 시간을 가진다. 또한 CRCW 알고리즘을 CREW PRAM 모델에서 구현한 CREW 알고리즘은 OMICRON (log^2 m)의 기대 수행 시간을 가지지만,OMICRON (m/logm) 개의 프로세서만을 가지고 수행될 수 있다.Abstract This paper presents simple randomized parallel algorithms for finding a maximal matching in an undirected graph G=(V, E) for the CRCW and CREW PRAM models. The algorithm for the CRCW model has {{{{ OMICRON (log m) expected running time using m processors, where m is the number of edges in G We also show that the CRCW algorithm can be implemented on a CREW PRAM. The CREW algorithm runs in {{{{ OMICRON (log^2 m) expected time, but it requires only OMICRON (m / log m) processors.

• The Korean Journal of Pain
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• v.25 no.4
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• pp.238-244
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• 2012

Background: Vitamin E is widely known to be one of the reactive oxygen species (ROS) scavengers and a drug that can easily be obtained, and it has been shown to attenuate the pain responses induced by various causes in animal pain models. Thus, this experiment was conducted to assess the antinociceptive effects of vitamin E by comparing intraperitoneal and intrathecal injections in rats subjected to the formalin test. Methods: After the intraperitoneal and intrathecal injections of vitamin E were carried out, respectively (IP: 500 mg/kg, 1 g/kg, and 2 g/kg, IT: 3 mg/kg, 10 mg/kg, and 30 mg/kg), the formalin test was perfumed. As soon as 5% formalin was injected into left hind paw, the number of flinches induced by pain was measured at 5-minute intervals for 1 hour. Results: Formalin injected into the left hind paw induced biphasic nociceptive behavior in all animals. Intraperitoneal injection of vitamin E diminished the nociceptive behavior in a dose-dependent manner during the early and late phase. Intrathecal vitamin E diminished nociceptive behavior dose dependently during the late phase but showed no significant difference in the early phase. Conclusions: Vitamin E attenuated acute nociception when it was injected systemically, while both systemic and intrathecal injection produced analgesia in a rat model of formalin-induced hyperalgesia.

• Journal of The Korean Astronomical Society
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• v.43 no.2
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• pp.25-39
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• 2010

We perform kinetic simulations of diffusive shock acceleration (DSA) in Type Ia supernova remnants (SNRs) expanding into a uniform interstellar medium (ISM). Bohm-like diffusion due to self-excited $Alfv\acute{e}n$ waves is assumed, and simple models for $Alfv\acute{e}nic$ drift and dissipation are adopted. Phenomenological models for thermal leakage injection are considered as well. We find that the preshock gas temperature is the primary parameter that governs the cosmic ray (CR) acceleration efficiency and energy spectrum, while the CR injection rate is a secondary parameter. For SNRs in the warm ISM of $T_0\lesssim10^5K$, if the injection fraction is $\xi\gtrsim10^{-4}K$, the DSA is efficient enough to convert more than 20% of the SN explosion energy into CRs and the accelerated CR spectrum exhibits a concave curvature flattening to $E^{-1.6}$, which is characteristic of CR modified shocks. Such a flat source spectrum near the knee energy, however, may not be reconciled with the CR spectrum observed at Earth. On the other hand, SNRs in the hot ISM of$T_{0}\approx10^{6}K$ with a small injection fraction, $\xi$<$10^{-4}$, are inefficient accelerators with less than 10% of the explosion energy getting converted to CRs. Also the shock structure is almost test-particle like and the ensuing CR spectrum can be steeper than $E^{-2}$. With amplified magnetic field strength of order of $30{\mu}G$ $Alfv\acute{e}n$ waves generated by the streaming instability may drift upstream fast enough to make the modified test-particle power-law as steep as $E^{-2.3}$, which is more consistent with the observed CR spectrum.

• Management Science and Financial Engineering
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• v.15 no.2
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• pp.1-21
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• 2009

We consider an $M^x/G/1$ queueing system with a random setup time under Bernoulli vacation schedule, where the service of the first unit at the completion of each busy period or a vacation period is preceded by a random setup time, on completion of which service starts. However, after each service completion, the server may take a vacation with probability p or remain in the system to provide next service, if any, with probability (1-p). This generalizes both the $M^x/G/1$ queueing system with a random setup time as well as the Bernoulli vacation model. We carryout an extensive analysis for the queue size distributions at various epochs. Further, attempts have been made to unify the results of related batch arrival vacation models.

• The Journal of Society for e-Business Studies
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• v.9 no.3
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• pp.113-128
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• 2004

Up to the present, most of the previous works, related to the alignment of organizations, have been focused on the alignment between business and information technology. Also these works have been done with single element, e.g., view rather than with overall elements such as view, scope, and perspective for enterprise-wide integrated alignment. Meanwhile, an enterprise architecture is a blueprint that represents the structure of components of organizations and their interrelationships. Nowadays, many organizations attempt to make enterprise-wide alignment of business and information technology based on enterprise architecture. Unfortunately, the enterprise-wide alignment is still in a stage of not only conceptual level but also abstract level. Hence, this paper proposes a structured enterprise-wide alignment model to overcome the limitations of existing alignment models. We survey the existing works and propose the conceptual, the logical, and the physical models for enterprise-wide alignment which includes 3-dimensional elements such view, scope, and perspective based on enterprise architecture. Finally, we have shown that the proposed model is better than existing ones through comparing the characteristics of models.

• Nutrition Research and Practice
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• v.17 no.6
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• pp.1056-1069
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• 2023

BACKGROUND/OBJECTIVES: Grifola frondosa, commonly referred to as the maitake mushroom, has been studied extensively to explore its potential health benefits. However, its anti-inflammatory effects in skin disorders have not been sufficiently elucidated. This study aimed to elucidate the anti-inflammatory role of the ethanol extract of G. frondosa in atopic dermatitis (AD) using in vivo and in vitro models. MATERIALS/METHODS: We investigated its impact on skin and spleen inflammatory responses in Dermatophagoides farinae extract (DFE)/1-chloro-2,4 dinitrochlorobenzene (DNCB)-induced AD-like skin lesions in a mouse model. Additionally, we determined the immunosuppressive response and mechanism of G. frondosa by inducing atopic-like immune reactions in keratinocytes through tumor necrosis factor (TNF)-α/interferon (IFN)-γ stimulation. RESULTS: Our study revealed that G. frondosa ameliorates clinical symptoms in an AD-like mouse model. These effects contributed to the suppression of Th1, Th2, Th17, and Th22 immune responses in the skin and spleen, leading to protection against cutaneous inflammation. Furthermore, G. frondosa inhibited the production of antibodies immunoglobulin (Ig)E and IgG2a in the serum of AD mice. Importantly, the inhibitory effect of G. frondosa on inflammatory cytokines in TNF-α/IFN-γ-stimulated AD-like keratinocytes was associated with the suppression of MAPK (Mitogen Activated Protein Kinase) pathway activation. CONCLUSIONS: Collectively, these findings highlight the potential of G. frondosa as a novel therapeutic agent for AD treatment and prevention.

• Journal of Information Technology Applications and Management
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• v.19 no.1
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• pp.25-36
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• 2012

Social Commerce recently attracted the attention of academic and industry researchers. Social Commerce aims to make a transactional environment which is beneficial to three parties-social commerce service provider, buyer and seller by way of using the platform of SNS. As Social Commerce is a new technology issue, there is no existing conceptual framework, e.g. appropriate classification the business types, that help to understand the nature of Social Commerce. This study suggests one classification framework and tries to verify whether it works.

• Proceedings of the Korean Society of Broadcast Engineers Conference
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• 1996.06a
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• pp.209-212
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• 1996

In this paper, we propose to re-size images using an oblique projection operator instead of the orthogonal one in order to obtain faster, simpler, and more general algorithms. The main advantage is that it becomes perfectly feasible to use higher order models(e.g., splines of degree n 3). We develop the theoretical background and present a simple and practical implementation procedure that uses B-splines. Experiments show that the proposed algorithm consistently outperforms the standard interpolation method and that it essentially provides the same performance as the optimal procedure (least squares solution) with considerably less computations.