• 한국산학기술학회논문지
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• 제18권2호
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• pp.549-558
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• 2017

본 연구는 체지방률이 32% 이상인 폐경 후 비만여성 36명을 대상으로 유산소운동이 혈청지질, 렙틴, 그렐린 및 인슐린저항성지수에 미치는 영향을 구명하기 위하여 운동집단(18명)과 통제집단(18명)으로 나누어 유산소운동인 라인댄스를 16주간 실시한 후 체조성, 혈청지질, 렙틴, 그렐린 및 인슐린저항성지수를 운동전과 후로 측정하여 비교분석하였다. 본 연구의 결과 운동 후에 운동집단에서 체중, 체지방률(%BF), 체질량지수(BMI), 내장지방면적(VFA), 렙틴(Leptin), 인슐린(Insulin), 글루코스(Glucose), 인슐린저항성지수(HOMA-IR), 총콜레스테롤(TC), 중성지방(TG), 아포리포프로틴(Apolipoprotein) B, 저밀도지단백 콜레스테롤(LDL-C) 및 수축기혈압(SBP)이 유의하게 감소하였다. 또한 아포리포프로틴(Apolipoprotein) A-1, 그렐린(Ghrelin) 및 고밀도지단백 콜레스테롤(HDL-C)이 유의하게 증가하였다. 유산소운동집단의 내장지방면적에 영향을 미치는 에너지대사조절인자의 회귀분석결과에서 주요요인으로 그렐린, 인슐린, 글루코스 및 HOMA-IR 나타났다. 따라서 규칙적이고 지속적인 유산소운동이 폐경 후 비만여성의 체조성, 내장지방, 혈청지질, 렙틴, 그렐린 및 HOMA-IR을 개선시키는 데 효과가 있을 것으로 생각된다.

• Molecules and Cells
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• 제21권1호
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• pp.52-62
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• 2006

In previous reports we demonstrated that ginsenosides, active ingredients of Panax ginseng, affect some subsets of voltage-dependent $Ca^{2+}$ channels in neuronal cells expressed in Xenopus laevis oocytes. However, the major component(s) of ginseng that affect cloned $Ca^{2+}$ channel subtypes such as ${\alpha}_{1C}$(L)-, ${\alpha}_{1B}$(N)-, ${\alpha}_{1A}$(P/Q)-, ${\alpha}_{1E}$(R)- and ${\alpha}_{1G}$(T) have not been identified. Here, we used the two-microelectrode voltage clamp technique to characterize the effects of ginsenosides and ginsenoside metabolites on $Ba^{2+}$ currents ($I_{Ba}$) in Xenopus oocytes expressing five different $Ca^{2+}$ channel subtypes. Exposure to ginseng total saponins (GTS) induced voltage-dependent, dose-dependent and reversible inhibition of the five channel subtypes, with particularly strong inhibition of the ${\alpha}_{1G}$-type. Of the various ginsenosides, $Rb_1$, Rc, Re, Rf, $Rg_1$, $Rg_3$, and $Rh_2$, ginsenoside $Rg_3$ also inhibited all five channel subtypes and ginsenoside $Rh_2$ had most effect on the ${\alpha}_{1C}$- and ${\alpha}_{1E}$-type $Ca^{2+}$ channels. Compound K (CK), a protopanaxadiol ginsenoside metabolite, strongly inhibited only the ${\alpha}_{1G}$-type of $Ca^{2+}$ channel, whereas M4, a protopanaxatriol ginsenoside metabolite, had almost no effect on any of the channels. $Rg_3$, $Rh_2$, and CK shifted the steady-state activation curves but not the inactivation curves in the depolarizing direction in the ${\alpha}_{1B}$- and ${\alpha}_{1A}$-types. These results reveal that $Rg_3$, $Rh_2$ and CK are the major inhibitors of $Ca^{2+}$ channels in Panax ginseng, and that they show some $Ca^{2+}$ channel selectivity.

• Journal of Animal Science and Technology
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• 제46권5호
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• pp.821-832
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• 2004

80두의 3원교잡종 돼지를 이용하여, 40일간 글라이신 베타인이 함유된 시험사료를 급여한 후 도축하여 글라이신 베타인 급여가 돈육 등심의 품질에 미치는 효과를 측정하였다. 돈육 등심내 글라이신 베타인의 축적율은 글라이신 베타인의 급여량이 높을수록 높게 나타났다(P<0.05). 0.4% 글라이신 베타인 급여구는 저장기간의 증가에 따라 등심육의 pH가 유의적으로 (P<0.05) 증가하였으며, 저장 13일에는 글라이신 베타인 급여구가 대조구에 비교해 유의적으로(P<0.05) 높은 pH를 나타내었다. 글라이신 베타인 급여 수준에 의한 명도값$(L^*)$은 유의적인 차이를 나타내지 않았으며, 적색도$(a^*)$ 또한 글라이신 베타인의 급여에 의한 주목할만한 경향을 나타내지 않았다. 황색도 $b^*$는 저장 9일에 0.4%와 0.6% 글라이신 베타인 급여구가 대조구와 0.2% 글라이신 베타인 급여구에 비교해 유의적으로 (P<0.05) 낮게 냐타났다. 또한 저장 13일에는 0.6% 급여구가 가장 낮은(P<0.05) 황색도 값을 나타내었다. 글라이신 베타인 급여에 의한 전단력 차이에서는 글라이신 베타언급여구가 대조구에 비교해 유의적으로(P<0.05) 높은 전단가를 나타내었다. 또한 저장 9일까지는 0.4% 글라이신 베타인 급여구가 가장 높은(P<0.05) 전단력을 나타내었으며, 저장 13일에는 0.2% 글라이신 베타인 급여구가 유의적으로(P<0.05) 가장 높은 전단력을 나타내었다. 근절의 길이의 변화를 보면 0.6% 글라이신 베타인 급여구가 전 저장기간동안 기장 짧은(P<0.05) 근절길이를 냐타내었으며, 대조구의 근절길이는 전 저장기간동안 가장 길게 나타났다. 지방산패도의 변화는 저장기간이 경과할수록 모든 처리구의 지방산패도는 유의적으로(P<0.05) 증가하였으나, 처리구간의 지방산패도는 전 저장기간동안 유의적인 차이를 나타내지 않았다. 글라이신 베타인의 급여에 의해 불포화지방산의 함량은 감소하고 포화지방산의 함량은 증가하는 결과를 나타내었다. 특히 linoleic acid와 myristic acid는 글라이신 베타인의 급여수준이 높을수록 감소하는(P<0.05) 경향을 나타내었다. 신선육의 관능검사에서 육색은 저장 1일차에 글라이신 베타인 급여구가 대조구에 비교해 유의적으로(P<0.05) 높게 나타났으나 저장기간이 경과한 이후에는 처리구간의 육색은 차이가 나타나지 않았다. 그러나 신선육 육향과 전체적언 가호도 및 가열육 관능검사는 처려구간의 주목할만한 차이를 나타내지 않았다.

• Tuberculosis and Respiratory Diseases
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• 제72권2호
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• pp.132-139
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• 2012

Background: Periostin is preferentially expressed in periosteum, indicating a potential role in bone formation. Recently, there have been emerging controversies about its role in invasion and metastasis of human malignancies. We attempted to determine the clinicopathological significance of periostin expression in non-small cell lung carcinoma (NSCLC). Methods: Immunohistochemical staining of periostin protein from 91 cases of NSCLCs was performed using tissue microarray blocks. The results were correlated with clinicopathological parameters. Results: Positive reaction to periostin was predominantly noted in the tumor stroma. The strongest reaction presented as a band-like pattern just around the tumor nests. Non-neoplastic lung tissue and most in-situ carcinomas did not show a positive reaction in their stroma. With respect to tumor differentiation, moderate to poor differentiated tumors (47/77) revealed even higher periostin expression than the well-differentiated ones (4/14) (p=0.024). High periostin expression was positively correlated with E-cadherin and p53 expression, but was not related with patient age, sex, tumor type, PCNA index, b-catenin, cyclin D1, pTNM-T, pTNM-N, stage, and patient survival (p>0.05). Conclusion: These results suggest that periostin might play a role during the biological progression of NSCLC, but may not be related to the clinical prognostic parameters.

• International Journal of Industrial Entomology and Biomaterials
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• 제26권1호
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• pp.22-30
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• 2013

The reproductive performance of multivoltine breed 'Nistari' and bivoltine breeds as NB18, P5 and a bivoltine hybrid (NB18 ${\times}$ P5) of B. mori were studied in different seasons in terms of total number of eggs laid, unlaid and hatching efficiency of the laid eggs to critically assess the breeds / hybrid potentiality. The bivoltine hybrid showed better performance in all the seasons as compared to the breeds investigated, as expected due to possibility of hybrid vigour. Among the breeds, bivoltine P5 had a better egg laid performance in S1 (February - March), S2 (May - June) and S3 (September - October) seasons but with an increase in the number of unlaid eggs. The hatching percentage, although didn't show any definitive trend, still suggested a marginal better performance in the hybrid. Most importantly, egg laying rhythmicity was studied by mating the female moth at 6.00 a.m. for $3{\frac{1}{2}}$ hours, and subsequently allowing the laying of eggs both under BOD condition ($25{\pm}1^{\circ}C$ and $85{\pm}5%$ RH) and at ambient temperature ($23-28^{\circ}C$ and $74.7{\pm}5%$) separately. Maximum (90%) egg laid occurred from 3.30 to 7.30 pm (i.e. 4 - 6 h after decoupling). Similar laying patterns were observed when females where mated at 12 noon and decoupled at 3.30 pm, revealing that late photoperiod and early scotoperiod were favourable for egg laying in case of multivoltine breed and bivoltine prefers late photoperiod for egg laying.

• 대한한방내과학회지
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• 제34권4호
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• pp.362-374
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• 2013

Objectives : This study was carried out to investigate the inhibitory effect of Banhasasim-tang on early reflux esophagitis by control of gastric peristalsis and the lower esophageal sphincter in mice. Methods : Experimental mice were classified into three groups. The normal group were mice with no inflammation. The control group were mice with gastroesophageal reflux elicited by alcohol. The sample group were mice administered Banhasasim-tang after gastroesophageal reflux elicitation. We observed morphological change and production of ghrelin, substance P, and inducible nitric oxide synthase (iNOS) in gastroesophageal junction mucosa. In addition, we examined change of epithelial junction in esophageal mucosa and change of lower esophageal sphincter distribution. Results : The migration of inflammation-related cells in lamina propria of gastroesophageal junction decreased more in the sample group than in the control group. The positive reaction of ghrelin, substance P, and iNOS significantly decreased more in the sample group than in the control group (p<0.05). Injury of the epithelial junction in the esophageal mucosa and outer oblique layer in the lower esophageal sphincter were significantly mitigated by Banhasasim-tang administration in the sample group (p<0.05). Conclusions : According to the above results, it is supposed that Banhasasim-tang inhibits early reflux esophagitis by controlling not only gastric peristalsis and acid secretion through ghrelin, and substance P but also the lower esophageal sphincter through iNOS.

• Journal of Gastric Cancer
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• 제17권2호
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• pp.186-191
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• 2017

The role of nodal station No. 14v (along the superior mesenteric vein) in lymphadenectomy for distal gastric cancer remains elusive. A 73-year-old woman underwent endoscopic submucosal dissection for gastric cancer, and was referred to our division for additional surgery because of pathologically non-curative resection. A laparoscopic distal gastrectomy with D1+ dissection was performed, with a final diagnosis of pT1bN1M0, Stage IB (2 nodal metastases to No. 6). Four months post-surgery, abdominal computed tomography revealed a 14-mm solitary nodule along the superior mesenteric vein. The lesion was excised and pathologically identified as a lymph node metastasis. Adjuvant chemotherapy with tegafur-gimeracil-oteracil potassium (S-1) was administered for the metastasis. Presently the patient survives without recurrence, 5.5 years after the second operation. Our findings suggest that there is lymphatic flow from the No. 6 to the No. 14v nodal station. Some patients with a No. 6 metastasis may benefit from a No. 14v lymphadenectomy, even in early-staged disease.

• 한국자원식물학회지
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• 제20권3호
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• pp.234-241
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• 2007

The present study was undertaken to classify and describe the riparian vegetation of the 6 river${\cdot}$stream of Korea Peninsula. As a result the vegetation was divided into nineteen communities. The vegetation units obtained in the present study were as follow: A: Salix koreensis community, B: Salix gracilistyla community, C: Robinia pseudo-acacia community, D: Amorpha fluticosa community, E: Brousonnetia papyrifera community, F: Phyllostachys bambusoides community, G: Rubus corchorifolius community, H: Phramities japonica community, I: Phramites communis community, J: Miscanthus sacchariflorus community, K: Miscanthus sinesis var. purpurascens community, L: Artemisia princeps var. orientalis community, M: Humulus japonicus community, N: Zoysia japonica community, O: Inperata cylindrica var. koenigii community, P: Agropyron tsukushiense var. transiens community, Q: Juncos effusus var. decipiens community, R: Rumex crispus community, S: Persicaria hydropiper community. The vegetation characteristics of riversides was recovered in the surveyed results according to river${\cdot}$stream basin, in other words, 10 communities in the upper river${\cdot}$stream riparian, 15 communities in the middle river${\cdot}$stream riparian, 10 communities in the down river${\cdot}$stream riparian. The Phragmites japonica community in the upper and Phragmites communis community in the down was analyzed by common community of the 6 river${\cdot}$stream riparian, respectively, but none in the middle. The standing profile of vegetation across 6 river${\cdot}$stream was seen stepwise Phragmites japonica community, Salix gracilistyla community, Miscanthus sinensis var. purpurascens community, shrub community by natural waterway in the upper, Salix gracilistyla community, Phragmites communis community, Rumex crispus community, Miscanthus sacchariflorus community, Humulus japonicus community in the middle, Phragmites communis community in the down. The differences of distributional featurs of vegetation emerged from the riparian of the 6 river${\cdot}$stream, but don't from the 6 river${\cdot}$stream.

• Restorative Dentistry and Endodontics
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• 제46권4호
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• pp.52.1-52.11
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• 2021

Objectives: This study evaluated the effects of low and moderate concentrations of triple antibiotic paste (TAP) and double antibiotic paste (DAP) loaded into a hydrogel system on crown discoloration and explored whether application of an adhesive bonding agent prevented crown discoloration. Materials and Methods: Intact human molars (n = 160) were horizontally sectioned 1 mm apical to the cementoenamel junction. The crowns were randomized into 8 experimental groups (calcium hydroxide, Ca[OH]₂; 1, 10, and 1,000 mg/mL TAP and DAP; and no medicament. The pulp chambers in half of the samples were coated with an adhesive bonding agent before receiving the intracanal medicament. Color changes (ΔE) were detected by spectrophotometry after 1 day, 1 week, and 4 weeks, and after 5,000 thermal cycles, with ΔE = 3.7 as a perceptible threshold. The 1-sample t-test was used to determine the significance of color changes relative to 3.7. Analysis of variance was used to evaluate the effects of treatment, adhesive, and time on color change, and the level of significance was p < 0.05. Results: Ca(OH)₂ and 1 and 10 mg/mL DAP did not cause clinically perceivable tooth discoloration. Adhesive agent use significantly decreased tooth discoloration in the 1,000 mg/mL TAP group up to 4 weeks. However, adhesive use did not significantly improve coronal discoloration after thermocycling when 1,000 mg/mL TAP was used. Conclusions: Ca(OH)₂ and 1 and 10 mg/mL DAP showed no clinical discoloration. Using an adhesive significantly improved coronal discoloration up to 4 weeks with 1,000 mg/mL TAP.

• Restorative Dentistry and Endodontics
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• 제46권2호
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• pp.22.1-22.12
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• 2021

Objectives: This study evaluated and compared the effects of radiation therapy on the dislocation resistance of AH Plus and BioRoot RCS applied to dentin and the sealer-dentin interface. Materials and Methods: Thirty single-rooted teeth were randomly assigned to 2 groups (n = 15 each): AH Plus (Dentsply DeTrey) and BioRoot RCS (Septodont). Each group was subdivided into control and experimental groups. The experimental group was subjected to a total radiation dose of 60 Gy. The root canals of all samples were cleaned, shaped, and obturated using the single-cone technique. Dentin slices (1 mm) were sectioned from each root third for the push-out test and scanning electron microscopy (SEM) was done to examine the sealer-dentin interface. The failure mode was determined using stereomicroscopy. Bond strength data were analyzed by the independent t-test, 1-way analysis of variance, and the Tukey post hoc test (α = 0.05). Results: Significantly lower bond strength was observed in irradiated teeth than non-irradiated teeth in the AH Plus group (p < 0.05). The BioRoot RCS group showed no significant reduction in bond strength after irradiation (p > 0.05) and showed a higher post-irradiation bond strength (209.92 ± 172.26 MPa) than the AH Plus group. SEM revealed slightly larger gap-containing regions in irradiated specimens from both groups. Conclusions: The dislocation resistance of BioRoot RCS was not significantly changed by irradiation and was higher than that of AH Plus. BioRoot RCS may be the sealer of choice for root canal treatment in patients undergoing radiation therapy.