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Schisandra Chinensis Baillon regulates the gene expression of phase II antioxidant/detoxifying enzymes in hepatic damage induced rats

  • Jang, Han I;Do, Gyeong-Min;Lee, Hye Min;Ok, Hyang Mok;Shin, Jae-Ho;Kwon, Oran
    • Nutrition Research and Practice
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    • v.8 no.3
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    • pp.272-277
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    • 2014
  • BACKGROUND/OBJECTIVES: This study investigated the antioxidant activities and hepatoprotective effects of Schisandra chinensis Baillon extract (SCE) against tert-butyl hydroperoxide (t-BHP)-induced oxidative hepatic damage in rats. MATERIALS/METHODS: Sprague-Dawley (SD) rats were pretreated with SCE (300, 600, and 1,200 mg/kg BW) or saline once daily for 14 consecutive days. On day 14, each animal, except those belonging to the normal control group, were injected with t-BHP (0.8 mmol/kg BW/i.p.), and all of the rats were sacrificed 16 h after t-BHP injection. RESULTS: Although no significant differences in AST and ALT levels were observed among the TC and SCE groups, the high-dose SCE group showed a decreasing tendency compared to the TC group. However, erythrocyte SOD activity showed a significant increase in the low-dose SCE group compared with the TC group. On the other hand, no significant differences in hepatic total glutathione (GSH) level, glutathione reductase (GR), and glutathione peroxidase (GSH-Px) activities were observed among the TC and SCE groups. Hepatic histopathological evaluation revealed that pretreatment with SCE resulted in reduced t-BHP-induced incidence of lesions, such as neutrophil infiltration, swelling of liver cells, and necrosis. In particular, treatment with a high dose of SCE resulted in induction of phase II antioxidant/detoxifying enzyme expression, such as glutathione S-transferase (GST) and glutamate-cysteine ligase catalytic subunit (GCLC). CONCLUSIONS: Based on these results, we conclude that SCE exerts protective effects against t-BHP induced oxidative hepatic damage through the reduction of neutrophil infiltration, swelling of liver cells, and necrosis. In addition, SCE regulates the gene expression of phase II antioxidant/detoxifying enzymes independent of hepatic antioxidant enzyme activity.

A Research on the Digital Controller of Switched Reluctance Motor Using DSP (DSP를 이용한 Switched Reluctance Motor의 디지털 제어기에 관한 연구)

  • 박성준;박한웅;김정택;추영배;이만형
    • The Transactions of the Korean Institute of Power Electronics
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    • v.3 no.3
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    • pp.263-272
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    • 1998
  • This paper presents the new control strategy that can minimizes the torque ripple by considering the magnetic nonlinearity and phase torque averlapping intervals, and describes the whole SRM drive system using proposed control method implemented by DSP(Digital Signal Processor). To do this, inductance and torque are, at first, measured according to the variation of rotor position angle while current is kept constant at predetermined several values. From these measured values, the entire inductance and torque for any current and rotor position are inferred by using neural network. And the waveform of the reference phase torque is determined for the torque ripple to be minimized considering the torque overlap between phases. The controller is designed for the actual torque obtained by the inferred torque look-up table using measured current and rotor position angle to track the predetermined reference phase torque by delta modulation technique. To perform a real time processing and ensure the reliability of the controller, DSP is implemented.

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Developing Forest Sustainability Indices of Provinces in South Korea (시도별 산림지속성의 지수화)

  • Kim, Joon-Soon;Sung, Joo Han;Kim, Joong Myung
    • Journal of Korean Society of Forest Science
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    • v.95 no.6
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    • pp.696-704
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    • 2006
  • This study was carried out to evaluate the forest sustainability index of metropolitan and provincial districts in Korea. The forest sustain ability was assessed on the bases of economic, social, environmental axes (phase), which are essential for sustainable development, and establishment. Score of importance for each phase was analyzed by the pairwise comparison of analytic hierachy process (AHP). The forest sustainability indices were measured by 15 indicators of each 3 indicators in economic, social and environmental aspects and 6 indicators in the establishment of infrastructure. The extra weight values of indicators were assigned by the value sum weight method. The forest sustainability indices were assessed for each phase, forest management and health, and integrated index, based on the data from 1995 to 2004. The forest sustain ability indices showed the highest score of 71.8 in Gyeongsangbuk-do and the lowest score of 22.9 in Incheon as of 2004.

Effect of Surface Environment on Front Squat of Crossfit Athletes (지면환경이 크로스핏 선수의 프론트 스쿼트에 미치는 영향)

  • Jang, Yootae;Yoon, Sukhoon
    • Korean Journal of Applied Biomechanics
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    • v.32 no.2
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    • pp.49-55
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    • 2022
  • Objective: This study aims to verify the front squat motions using by two different surfaces, thereby elucidating the grounds for effective training environment that can minimize the risk of injury. Method: Total of 10 healthy male crossfit athletes were recruited for this study (age: 32.30 ± 3.05 yrs., height: 173.70 ± 5.12 cm, body mass: 82.40 ± 6.31 kg, 1RM: 160 ± 13.80 kg). All participants are those who know how to do front squats well with more than five years of crossfit athlete experience. All participants have sufficient experience in front squats on two types of surface which are soft surface (SS) and hard surface (HS). In each surface, participant perform 10reps of the front squat with 80% of the pre-measured 1RM. A 3-dimensional motion analysis with 8 infrared cameras and 2 channels of EMG was performed in this study. Paired sample t-test was used for statistical verification between two surfaces. The significant level was set at α=.05. Results: The significantly decreased rectus femoris muscle activation was found in SS compared with that of HS on phase 1 (p<.05). Also, ROM of ankle joint was significantly increased in the SS compare with that of HS on phase 1 (p<.05). The muscle activity ratio of gluteus maximus/rectus femoris showed a significant difference only in SS compared with that of HS on phase 1 (p<.05). Conclusion: In conclusion, Korean crossfit boxes should consider the use of hard surface, which has a relatively less risk of injury than soft surface, in selecting flooring materials. For the Crossfit athletes, they are also considered appropriate to train on a relatively hard surface.

Influence of UTLS Ozone on the QBO-MJO Connection: A Case Study Using the GloSea5 Model (상부 대류권-하부 성층권 오존이 성층권 준 2년주기 진동과 매든-줄리안 진동 상관성에 미치는 영향: GloSea5 이용 사례)

  • Oh, Jiyoung;Son, Seok-Woo;Back, Seung-Yoon
    • Atmosphere
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    • v.32 no.3
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    • pp.223-233
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    • 2022
  • Recent studies have shown that Madden-Julian Oscillation (MJO) is modulated by Quasi-Biennial Oscillation (QBO) during the boreal winter; MJO becomes more active and predictable during the easterly phase of QBO (EQBO) than the westerly phase (WQBO). Despite growing evidences, climate models fail to capture the QBO-MJO connection. One of the possible reasons is a weak static stability change in the upper troposphere and lower stratosphere (UTLS) by neglecting QBO-induced ozone change in the model. Here, we investigate the possible impact of the ozone-radiative feedback in the tropical UTLS on the QBO-MJO connection by integrating the Global Seasonal Forecasting System 5 (GloSea5) model. A set of experiments is conducted by prescribing either the climatological ozone or the observed ozone at a given year for the EQBO-MJO event in January 2006. The realistic ozone improves the temperature simulation in the UTLS. However, its impacts on the MJO are not evident. The MJO phase and amplitude do not change much when the ozone is prescribed with observation. While it may suggest that the ozone-radiative feedback plays a rather minor role in the QBO-MJO connection, it could also result from model biases in UTLS temperature and not-well organized MJO in the model.

X-ray/gamma radiation shielding properties of Aluminium-Bariume-Zinc Oxide nanoparticles synthesized via low temperature solution combustion method

  • K.V. Sathish;K.N. Sridhar;L. Seenappa;H.C. Manjunatha;Y.S. Vidya;B. Chinnappa Reddy;S. Manjunatha;A.N. Santhosh;R. Munirathnam;Alfred Cecil Raj;P.S. Damodara Gupta;B.M. Sankarshan
    • Nuclear Engineering and Technology
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    • v.55 no.5
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    • pp.1519-1526
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    • 2023
  • For the first time Aluminium-BariumeZinc oxide nanocomposite (ZABONC) was synthesized by solution combustion method where calcination was carried out at low temperatures (600℃) to study the electromagnetic (EM) (X/γ) radiation shielding properties. Further for characterization purpose standard techniques like PXRD, SEM, UV-VISIBLE, FTIR were used to find phase purity, functional groups, surface morphology, and to do structural analysis and energy band gap determination. The PXRD pattern shows (hkl) planes corresponding to spinel cubic phase of ZnAl2O4, cubic Ba(NO3)2, α and γ phase of Al2O3 which clearly confirms the formation of complex nano composite. From SEM histogram mean size of nano particles was calculated and is in the order of 17 nm. Wood and Tauc's relation direct energy band gap calculation gives energy gap of 2.9 eV. In addition, EM (X/γ) shielding properties were measured and compared with the theoretical ones using standard procedures (NaI (Tl) detector and multi channel analyzer MCA). For energy above 356 keV the measured shielding parameters agree well with the theory, while below this value slight deviation is observed, due to the influence of atomic/crystallite size of the ZABONC. Hence synthesized ZABONC can be used as a shielding material in EM (X/γ) radiation shielding.

A Distributed Real-Time Concurrency Control Scheme using Transaction the Rise of Priority (트랜잭션 우선 순위 상승을 이용한 분산 실시간 병행수행제어 기법)

  • Lee, Jong-Sul;Shin, Jae-Ryong;Cho, Ki-Hyung;Yoo, Jae-Soo
    • Journal of KIISE:Databases
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    • v.28 no.3
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    • pp.484-493
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    • 2001
  • As real-time database systems are extended to the distributed computing environment, the need to apply the existing real-time concurrency control schemes to the distributed computing environment has been made. In this paper we propose an efficient concurrency control scheme for distributed real-time database system. Our proposed scheme guarantees a transaction to commit at its maximum, reduces the restart of a transaction that is on the prepared commit phase, and minimizes the time of the lock holding. This is because it raises the priority of the transaction that is on the prepared commit phase in the distributed real-time computing environment. In addition, it reduces the waiting time of a transaction that owns borrowed data and improves the performance of the system, as a result of lending the data that the transaction with the raised priority holds. We compare the proposed scheme with DO2PL_PA(Distributed Optimistic Two-Phase Locking) and MIRROR(Managing Isolation in Replicated Real-time Object Repositories) protocol in terms of the arrival rate of transactions, the size of transactions, the write probability of transactions, and the replication degree of data in a firm-deadline real-time database system based on two-phase commit protocol. It is shown through the performance evaluation that our scheme outperforms the existing schemes.

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Cold Isostatic Pressing and Sintering Behavior of (Al +12.5%Cu)3Zr Nanocrystalline Intermetallic Compound Synthesized by Mechanical Alloying (기계적합금화한 (Al +12.5%Cu)3Zr 초미립 금속간화합물의 CIP 성형 및 소결 거동)

  • Moon, H.G.;Hong, K.T.;Kim, S.J.
    • Korean Journal of Materials Research
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    • v.12 no.8
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    • pp.634-640
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    • 2002
  • To improve the ductility of mTEX>$(Al +12.5%Cu)<_3$Zr intermetallics, which are the potential high temperature structural materials, the mechanical alloying behavior, the effect of pressure and temperature on the $Ll_2$, phase formation and the behavior of the cold isostatic press and sintering were investigated. However mechanically alloyed A1$_3$Zr alloy have been known to have high mechanical strength even at high temperature, its workability was poor. A method of solution is refined grain size and phase transformation from $DO_{23}$ to $Ll_2$.$ Ll_2$ structure TEX>$(Al+12.5%Cu)<_3$Zr with nanocrystalline microstructure intermetallic powders where were prepared by mechanical alloying of elemental powders. Grain sizes of the as milled powders were less than 10nm (from transmission electron microscopy, TEM). Thermal analyses showed that $Ll_2$ structure was stable up to$ 800^{\circ}C$ for 1hour $(Al+ 12.5%Cu)<_3$Zr. $(Al+12.5%Cu)<_3$Zr has been consolidated by cold isostatic pressing (CIP 138, 207, 276, 414MPa) at room temperature and subsequent heat treatment at high temperatures where $Ll_2$ structure was stable under vacuum atmosphere. The results showed that 94.2% density of Ll$_2$ compacts was obtained for the (Al +12.5%Cu)$_3$Zr by sintering at 80$0^{\circ}C$ for 1hour (under CIPed 207MPa). This compact of the grain size was 40nm.

Crystal Structure Changes of LiNi0.5Co0.2Mn0.3O2 Cathode Materials During the First Charge Investigated by in situ XRD

  • Lee, Sang-Woo;Jang, Dong-Hyuk;Yoon, Jeong-Bae;Cho, Yong-Hun;Lee, Yun-Sung;Kim, Do-Hoon;Kim, Woo-Seong;Yoon, Won-Sub
    • Journal of Electrochemical Science and Technology
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    • v.3 no.1
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    • pp.29-34
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    • 2012
  • The structural changes of $Li_{1-x}Ni_{0.5}Co_{0.2}Mn_{0.3}O_2$ cathode material for lithium ion battery during the first charge was investigated in comparison with $Li_{1-x}Ni_{0.8}Co_{0.15}Al_{0.05}O_2$ using a synchrotron based in situ X-ray diffraction technique. The structural changes of these two cathode materials show similar trend during first charge: an expansion along the c-axis of the unit cell with contractions along the a- and b-axis during the early stage of charge and a major contraction along the c-axis with slight expansions along the a- and b-axis near the end of charge at high voltage limit. In $Li_{1-x}Ni_{0.5}Co_{0.2}Mn_{0.3}O_2$ cathode, however, the initial unit cell volume of H2 phase is bigger than that of H1 phase since the c-axis undergo large expansion while a- and b- axis shrink slightly. The change in the unit cell volume for $Li_{1-x}Ni_{0.5}Co_{0.2}Mn_{0.3}O_2$ during charge is smaller than that of $Li_{1-x}Ni_{0.8}Co_{0.15}Al_{0.05}O_2$. This smaller change in unit cell volume may give the $Li_{1-x}Ni_{0.5}Co_{0.2}Mn_{0.3}O_2$ cathode material a better structural reversibility for a long cycling life.

IFC test between commercial 3D CAD application using IFC (IFC를 중심으로 한 상용 3D CAD의 호환성테스트)

  • Lim, Jae-In;Kim, Jae-Woo;Kwon, Hyuk-Do;Yoon, Su-Won;Kwon, Soon-Wook;Chin, Sang-Yoon
    • Korean Journal of Construction Engineering and Management
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    • v.9 no.3
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    • pp.85-94
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    • 2008
  • The process of construction industry basically consists of many complicated phase, such as planning, design, construction, MO&R(Maintenance, Operation, and Repair), and deconstruction. And various participants communicate each other during every phase of process. Since construction components have become more complex and diverse recently, many researches on how to exchange and standardization of building. However, in Korea research on IFC(Industry Foundation Classes) which is a standard for international data exchange have been conducted with only study limited Issues, such as studies on the development of 2D extension model for IFC, researches on 3D or 4D based IFC extension, and etc. This stuff covers tests of the compatibility among commercial 3D CAD programs using IFC file format. Several problems of the current IFC model are retrieved as a result.