• Journal of Integrative Natural Science
• /
• v.8 no.4
• /
• pp.273-284
• /
• 2015

Chemoattractant Receptor Homologous molecule expressed on Th2 cells (CRTh2) is a chemoattractant receptor with seven transmembrane helices targeted for inflammatory diseases such as asthma and allergic rhinitis. In this study, pharmacophore based Comparative Molecular Similarity Indices Analysis (CoMSIA) were performed on the series of 2-(2-(benzylthio)-1H-benzo[d]imidazol-1-yl) acetic acids derivatives. Initially, GASP module was used for generation of pharmacophore models using five highly active compounds from the dataset. Among the generated pharmacophores, the best pharmacophore model was selected based on fitness score and was used as template for the alignment of compounds which was used for CoMSIA analysis. The best predictions were obtained utilizing steric, hydrophobic and H-bond acceptor parameters showing a $q^2$=0.559 and $r^2$=0.730. 15 test set compounds was used to investigate the predictive ability of the CoMSIA model. Contour maps suggested that presence of bulky substituents and H-bond acceptor atoms at $5^{th}$ position of benzene ring will increase the activity of the compounds. The results obtained from this study will be useful to design more potent CRTh2 antagonists.

• Journal of Hydrogen and New Energy
• /
• v.18 no.4
• /
• pp.382-390
• /
• 2007

To check the feasibility of SMART(Steam Methane Advanced Reforming Technology) system, an experimental investigation was performed. A fluidized bed reactor of diameter 0.052m was operated cyclically up to 10th cycle, alternating between reforming and regeneration conditions. FCR-4 catalyst was used as the reforming catalyst and calcined limestone(domestic, from Danyang) was used as the $CO_2$ absorbent. Hydrogen concentration of 98.2% on a dry basis was reached at $650^{\circ}C$ for the first cycle. This value is much higher than $H_2$ concentration of 73.6% in the reformer of conventional SMR (steam methane reforming) condition. The hydrogen concentration decreased because the $CO_2$ capture capacity decreased as the number of cycles increased. However, the average hydrogen concentration at 10th cycle was 82.5% and this value is also higher than that of SMR. Based on these results, we could conclude that the SMART system can replace SMR system to generate pure hydrogen without HTS (high tempeature shift), LTS (low temperature shift) and $CO_2$ separation process.

• Proceedings of the Korean Society of Applied Pharmacology
• /
• 1993.04a
• /
• pp.34-35
• /
• 1993

The Development of new asymmetric induction methods useful for syntheses of biologically active natural products and drugs, using C4-chiral 1,3-th-iazolidine-2-thiones, has been a recent focus of interest. 1-8) The present account describes the significance of particular heterocycles in the synthetic development of new 1${\beta}$-substituted carbapenems. A fungal metabolite, (＋)-thienamycin (1) has attracted one's attention as a hopeful candidate for new-generation antibiotic drugs because of its strong antimicrobial activities and wide antimicrobial spectra due to the extensive inhibition against various ${\beta}$-lactamases. However, it has been serious problems toward a practically useful drug that (＋)-thienamycin is fairly labile in the solution and can be metabolized by renal dehydropept- idase-I (DHP-I). Recently, a Merck Sharp ＆ Dohme research group exploited a non-natural ${\beta}$-lactam, imipenem (2) which has been appeared in the drug market as the first carbapenem-type antibiotic drug. 9) However 2 must be used with a DHP-I inhibitor, cilastatin sodium (3).9) Thus, a 1,${\beta}$-methyl- carbapenem derivative 4 has been disclosed by the same group. 10) It seems to be more hopeful candidate as a new-generation antibiotic because it can directly resist against metabolism by the renal DHP-1 without an enzyme inhibitor 3. 10)

• International Journal of Railway
• /
• v.7 no.4
• /
• pp.100-108
• /
• 2014

A numerical analysis method for predicting aerodynamic noise at inter-coach space of high-speed trains, validated by wind-tunnel experiments for limited speed range, is proposed. The wind-tunnel testing measurements of the train aerodynamic sound pressure level for the new generation Korean high-speed train have suggested that the inter-coach space aerodynamic noise varies approximately to the 7.7th power of the train speed. The observed high sensitivity serves as a motivation for the present investigation on elucidating the characteristics of noise emission at inter-coach space. As train speed increases, the effect of turbulent flows and vortex shedding is amplified, with concomitant increase in the aerodynamic noise. The turbulent flow field analysis demonstrates that vortex formation indeed causes generation of aerodynamic sound. For validation, numerical simulation and wind tunnel measurements are performed under identical conditions. The results show close correlation between the numerically derived and measured values, and with some adjustment, the results are found to be in good agreement. Thus validated, the numerical analysis procedure is applied to predict the aerodynamic noise level at inter-coach space. As the train gains speed, numerical simulation predicts increase in the overall aerodynamic sound emission level accompanied by an upward shift in the main frequency components of the sound. A contour mapping of the aerodynamic sound for the region enclosing the inter-coach space is presented.

• Journal of Korea Entertainment Industry Association
• /
• v.15 no.3
• /
• pp.193-202
• /
• 2021

The purpose of this study was to examine relation of awareness and education requirement of the 4th industrial revolution in health care students in attempt to provide basic data of determining the principle and education plan. The subject of study were 280 students of health department of H university in Gwangju and analyzed by gender and grade. The female students were positive awareness of the 4th industrial revolution and the level of influence on the major field was highest in lower grade students. The level of negative factors such as generation gap(p<0.05), gap between rich and poor (p<0.01), personal information infringement(p<0.05), decrease in existing jobs(p<0.05), and abuse of artificial intelligence(p<0.05) was highest in male students. In prepration for the 4th industrial revolution, education on bio and medical device(22.2%) was the most desired. The higher positive awareness, the higher educational demand(p<0.001). It is necessary to develop programs and various education to increase positive factors such as the creation of new jobs and improve the quality of life in the era of the 4th industrial revolution.

• Asian-Australasian Journal of Animal Sciences
• /
• v.16 no.6
• /
• pp.794-799
• /
• 2003

A study was conducted on 2102 records of 808 crossbred cows of various genetic groups maintained under 'All India Coordinated Research Project on Cattle' at C C S Haryana Agricultural University, Hisar, over 25 years period (1968-1993) with an objective to assess and compare the amount of percent improvement and heterotic effect for different performance traits in various genetic groups produced under this programme. Survivability sharply and significantly declined from 1/2 to $3/4^th$ bred and further from $3/4^th$ to inter-se bred. This may be due to periodic and management differences in addition to the higher level of exotic inheritance and decreased heterotic effect over the filial generations. Jersey and Holstein Friesian crosses among 1/2 breds and their 50% inheritance among $3/4^th$ and inter-se breds had highest improvement and heterosis in reproduction and production traits respectively. Among inter se bred genetic groups, BFH (I) had no recombination loss in SP and CI, while FJH (I), JFH (I) and FBH (I) had on recombination loss in AFC, LY, LL and PE. The crossbreeding of zebu cows with exotic breeds brings about spectacular improvement in comparison to the performance of zebu breed, while conventional selection over several generation would lead to only modest improvement. In addition to additive effect, there was sufficient heterosis in Jersey crosses for reproduction and Holstein Friesian crosses for production performance. Three breed crosses with exotic inheritance between 50 and 75 percent incorporating genes (25 to 50%) from both of these breeds is the best combination for stabilization.

• Journal of the korean academy of Pediatric Dentistry
• /
• v.46 no.2
• /
• pp.165-172
• /
• 2019

The purpose of this study was to evaluate the effect of application time and phosphoric acid etching of 8th generation adhesives containing functional monomer on adhesive performance in primary teeth. 80 extracted non-carious human primary teeth were selected and divided into 8 groups based on 3 factors: (1) adhesive: G-Premio bond and Single bond universal; (2) application time: shortened time and manufacture's instruction; (3) acid etching mode: self-etching and total-etching. Shear bond strength was measured using a universal testing machine, and fractured surface were observed under scanning electron microscope. Microleakage was evaluated by dye penetration depth. G-Premio bond were not significant different in shear bond strength and microleakage depending on application time of adhesive and acid etching mode. In Single bond universal, shear bond strength of short application time was significantly lower than that of long adhesive application time (p = 0.014). Clinically applicable shear bond strength values (> 17 MPa) were identified in all groups. These results suggested that G-Premio bond be used clinically for a short application time without phosphoric acid etching.

• Journal of Christian Education in Korea
• /
• v.71
• /
• pp.241-276
• /
• 2022

Due to the 4th industrial revolution, which started with the Smart Revolution in the early 21st century, Hyper-Connectivity, Hyper-Convergence and Hyper-Intelligence of our society is accelerating. These changes induced formation of Metaverse as a fused new space that crosses the perimeter of the physical space and virtual(digital) spaces beyond time and place. The characteristics of Metaverse are continuously spread by engaging with the characteristics of the MZ generation, which collects both Millennial generation (M Generation) and Z Generation. With outburst of Covid-19 pandemic, a variety of attempts have been made to utilize Metaverse, even in church education when it was impossible to worship directly. In other words, the usefulness of the Metaverse was confirmed as a new community space of the education of the church. In addition, Metaverse may provide a substantial, experiential and evolving space for church education. However, in order for church education to further develop, the development in the method of education is also required to move beyond mere concept of space. In particular, when the learner-centered education method, one of the common characteristics of the Metaverse and MZ generation, it is thought that the church education in the Metaverse era will be able to go in a more evolving direction.

• 한국정보통신설비학회:학술대회논문집
• /
• 2008.08a
• /
• pp.525-530
• /
• 2008

There are a few core technologies to enable high-performance $4^{th}$ generation (4G) broadband wireless communication system. A multiple input multiple output (MIMO) provides high-rate transmission through expended channels by multiple array antennas in both sender and receiver side. Also orthogonal frequency division multiplexing (OFDM) is well-known as the most appropriate technique for high data rate transmission such as Mobile WiMAX and WLAN. Efficient decrease of inter-carrier interference (ISI) and inter-carrier interference (ICI) are the reasons for why OFDM is suitable for high-performance transmission, 4G mobile communication. In this paper, we mainly focus on two of objects, combination between MIMO and OFDM, and OFDM channel simulator using Ray-tracing algorithm. The results of this paper can be used implementation of a Wireless Software Platform for 4G Mobile Communication Systems.

• Korean Journal of Poultry Science
• /
• v.30 no.4
• /
• pp.235-244
• /
• 2003

This study was carried out to estimate the effects of strain and generation on the major production performances of Korean native chicken. The data were collected from 11,583 birds of the 7 generations over the year 1995 through 2001 at National Livestock Research Institute, Korea. Results obtained were summarized as follows: The body weights at 150 and 270 days of age were 1,557.7 and 1880.7, 1,471.7 and 1,738.2, 1,393.5 and 1,694.9, 1,591.2 and 1,910.0, 1,545.6 and 1,763.6g in Red Brown, Yellow Brown, Gray Brown, Black, and White strains, respectively. The Coefficient of Variations (CVs) of the body weights at 150 and 270 days of age were 9.65~13.79% and 13.29~15.16%. The ages at first egg were 150.0, 148.3, 149.5, 152,8 and 147.7 days in Red Brown, Yellow Brown, Gray Brown, Black and White strains, respectively and the CVs were between 9.33 and 10.11%. The egg weights at the first egg and 270 days of age were 33.2 and 50.8, 32.2 and 49.2, 32.2 and 49.1, 33.0 and 50.0, 30.7 and 47.8g respectively. The CVs of the egg weights of the first egg and at 270 days of age were 13.54~15.27% and 6.93~7.36%. The numbers of eggs produced by 270 days of age were 77.0, 79.3, 77.3, 73,7, 75.4, respectively, and observed CVs were between 29.98~36.99%. The significant strain effects were investigated in all the major economic traits in Korean native chicken. The significant strain effects were investigated in all the major economic traits in Korean native chicken. The highest least square (LS) means of the body weights at 150 and 270 days of age were observed in Black strain as 1,594.38 and 1,911.57g. The earliest LS mean of the ages at first egg was 146.88days in White strain. The heaviest LS means of egg weights at the first egg and 270 days of age were observed in Red Brown strain as 32.20 and 50.74g. The LS mean of the largest number of egg production was 79.50 eggs in Yellow Brown strain. Also, The significant generation effects were investigated in all the major economic traits. The highest LS means of the body weights at 150 and 270 days of age were observed in the generation 3 as 1,599.74 and 1,905.01g. The earliest LS mean of the age at first egg was 143.31 days in 4th generation. The heaviest LS means of egg weights at the first egg and 270 days of age were observed in 7th and 5th generation as 35.68 and 50.42g. The LS means of the largest number of egg production was 78.53 eggs in generation 6. In general, light body weight, short time for the age at first egg, heavy egg weight, and large number of egg production were observed as the generation proceeded.