• Title/Summary/Keyword: ${gamma}K$

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EFFECTS OF $INTERFERON-\gamma$ ON COLLAGEN AND FIBRONECTIN SYNTHESIS IN PRIMARY CULTURED PERIODONTAL LIGAMENT CELLS ($Interferon-\gamma$가 치주인대 세포의 Collagen 및 Fibronectin의 합성과 Alkaline Phosphatase 활성에 미치는 영향)

  • Kim, Gwang-Seok;Sung, Jae-Hyun;Choi, Je-Yong;Ryou, Hyun-Mo
    • The korean journal of orthodontics
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    • v.23 no.2 s.41
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    • pp.229-248
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    • 1993
  • [ $Interferon-\gamma$ ] has been suggested as a cytokine of connective tissue stabilizer. In addition, it has also been demonstrated that this cytokine inhibited bone remodeling activities of the bone derived cells. In order to illuminate the effects of this cytokine in orthodontic force induced bone remodeling, it was administered to primary cultured periodontal ligament cells which have been known to have some osteoblast like characteristics. $Interferon-\gamma$ slightly decreased $[^3H]thymidine$ incorporation rate without a significant change in the total cellular DNA content up to 1000 U/ml, which meant these doses were not cytotoxic to the cell. Total protein synthesis was not influenced by various concentration of interferon-y whether it was determined by the $[^3H]proline$ incorporation rate or by the Lowry smethod. The effect of $interferon-\gamma$ on the individual protein was, however, differential, ie, it increased $[^3H]proline$ incorporation into the noncollagenous protein marginally, while it decreased $[^3H]proline$ incorporation into the collagen, so that it caused dose-dependent suppression of the relative collagen synthesis. On the contrary, the fibronectin synthesis determined by the ELISA was increased by 1000 U/ml of $interferon-\gamma$. The differential effects of the interferon-y on the collagen and fibronectin synthesis exhibited not only their protein level but also the steady state mRNA level. $Interferon-\gamma$ decreased steady state level of ${\alpha}1(I)$ procollagen mRNA significantly, while showing no significant changes in the fibronectin mRNA level. In addition to this, it was also found that indomethacin did not affect on the $interferon-\gamma$ induced collagen decrease in this cell, which meant prostaglandins were not involed in the process of $interferon-\gamma$ induced collagen decrease. So it can be concluded that the incubation of periodontal ligament cells with 1000 U/ml of $interferon-\gamma$ for 24 hr showed differential effects on the type I collagen and fibronectin gene expression. The decrease in relative collagen synthesis in the protein level was related with decrease in the steady state level of mRNA, while the increase in the fibronectin synthesis in the protein level was not correlated with the mRNA level.

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Development of a Stereotactic Device for Gamma Knife Irradiation of Small Animals

  • Chung, Hyun-Tai;Chung, Young-Seob;Kim, Dong-Gyu;Paek, Sun-Ha;Cho, Keun-Tae
    • Journal of Korean Neurosurgical Society
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    • v.43 no.1
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    • pp.26-30
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    • 2008
  • Objective : The authors developed a stereotactic device for irradiation of small animals with Leksell Gamma Knife Model C. Development and verification procedures were described in this article. Methods : The device was designed to satisfy three requirements. The mechanical accuracy in positioning was to be managed within 0.5 mm. The strength of the device and structure were to be compromised to provide enough strength to hold a small animal during irradiation and to interfere the gamma ray beam as little as possible. The device was to be used in combination with the Leksell G-$frame^{(R)}$ and $KOPF^{(R)}$ rat adaptor. The irradiation point was determined by separate imaging sequences such as plain X-ray images. Results : The absolute dose rate with the device in a Leksell Gamma Knife was 3.7% less than the value calculated from Leksell Gamma $Plan^{(R)}$. The dose distributions measured with $GAFCHROMIC^{(R)}$ MD-55 film corresponded to those of Leksell Gamma $Plan^{(R)}$ within acceptable range. The device was used in a series of rat experiments with a 4 mm helmet of Leksell Gamma Knife. Conclusion : A stereotactic device for irradiation of small animals with Leksell Gamma Knife Model C has been developed so that it fulfilled above requirements. Absorbed dose and dose distribution at the center of a Gamma Knife helmet are in acceptable ranges. The device provides enough accuracy for stereotactic irradiation with acceptable practicality.

Reforming of Propane by Carbon Dioxide using Ni/γ-A12O3 Catalysts (Ni/γ-Al2O3 촉매상에서 이산화탄소에 의한 프로판의 개질)

  • Kim, K. H.;Kim, J. H.;Chang, S. C.;Park, D. W.
    • Applied Chemistry for Engineering
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    • v.8 no.3
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    • pp.382-388
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    • 1997
  • Reforming of propane by carbon dioxide using NiO/${\gamma}$-$A1_2O_3$ was carried out in a pulse or continuous kid bed reactor. NiO/${\gamma}$-$Al_2O_3$ showed higher dissociation ability of $CO_2$ than NiO/${\gamma}$-$Al_2O_3$, and the former exhibited higher conversion of propane than the latter. The presence of oxygen in the reaction mixture of propane and $CO_2$ increased the conversion of propane and reduced the amount of carbon deposit on the catalyst surface. Mechanical mixture catalyst of NiO/${\gamma}$-$Al_2O_3$ and $Ga_2O_3$ showed higher stability to deactivation than NiO/${\gamma}$-$Al_2O_3$ itself. The synergistic effect between NiO/${\gamma}$-$Al_2O_3$ and $Al_2O_3$ was also observed in this study.

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Effects of Combined Irradiation of Neutrons and ${\gamma}$-Rays on the Pink Mutation Frequencies in Tradescantia (중성자와 감마선 중복 조사가 자주달재비 분홍돌연변이율에 미치는 영향)

  • Kim, Jin-Kyu;Lee, Young-Keun;Kim, Jae-Sung;Shin, Hae-Shick;Hyun, Soung-Hee
    • Journal of Radiation Protection and Research
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    • v.25 no.2
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    • pp.67-73
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    • 2000
  • The effects of combined irradiation of neutrons and ${\gamma}$-rays were analysed by means of Tradescantia stamen hair (TSH) assay. Potted plants were irradiated with $0{\sim}2$ Gy of ${\gamma}$-rays. For the combined treatments, the plants were irradiated with neutrons from $^{252}Cf$ 24 hours before or after ${\gamma}$-irradiation. The slopes of dose-response curves were 5.98, 6.17 and 7.48, in ${\gamma}$-rays, ${\gamma}$-rays+neutrons, and neutrons+${\gamma}$ -rays irradiated groups, respectively. The biological efficacy of radiations in the induction of pink mutations increased by 25% in neutrons+${\gamma}$-rays irradiated group, while it increased by 12% in ${\gamma}$-rays+neutrons irradiated group. The combined irradiation with two kinds of radiations results in the different efficacy of radiation depending on the order of irradiations, which is of great importance in the related fields such as sterilization and radiotherapy.

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Influence of low dose ${\gamma}$ radiation on the physiology of germinative seed of vegetable crops (저선량 감마선이 채소 발아종자의 생리활성에 미치는 영향)

  • Kim, Jae-Sung;Lee, Eun-Kyung;Back, Myung-Hwa;Kim, Dong-Hee;Lee, Young-Bok
    • Korean Journal of Environmental Agriculture
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    • v.19 no.1
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    • pp.58-61
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    • 2000
  • This study was conducted to determine the effect of low dose ${\gamma}-ray$ on the germination rate and physiology of germinative seeds of welsh onion ( Allicm fistulosum L. cv. Sukchangwoidae ) and spinach ( Spinacia oleracea L. cv. Chungrok ). The germination rate of irradiation group was much higher than that of the control. Especially it was noticeably higher in 1 or 2 Gy irradiation groups in the sowing spinach seeds on paper towel. On the welsh onion, the germination rate of the 1 Gy irradiation group increased by 17% compared to that of the control. Ion leakage from seeds irradiated with low dose of ${\gamma}-ray$ was decreased compared to that from the control especially at the early stage of incubation when examined by means of electric conductance. This tendency was confirmed in seeds of welsh onion and spinach. Starch hydrolysis was stimulated by ${\gamma}-ray$ irradiation in welsh onion. Furthermore ${\gamma}-ray$ irradiation was beneficial to keeping the vitality of seeds as determined through decarboxylation of glutamic acid.

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HYPERBOLIC CURVATURE AND K-CONVEX FUNCTIONS

  • Song Tai-Sung
    • The Pure and Applied Mathematics
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    • v.13 no.2 s.32
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    • pp.151-155
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    • 2006
  • Let $\gamma$ be a $C_2$ curve in the open unit disk $\mathbb{D}. Flinn and Osgood proved that $K_{\mathbb{D}}(z,\gamma){\geq}1$ for all $z{\in}{\gamma}$ if and only if the curve ${\Large f}o{\gamma}$ is convex for every convex conformal mapping $\Large f$ of $\mathbb{D}, where $K_{\mathbb{D}}(z,\;\gamma)$ denotes the hyperbolic curvature of $\gamma$ at the point z. In this paper we establish a generalization of the Flinn-Osgood characterization for a curve with the hyperbolic curvature at least 1.

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A Study on the Optimization of Small Size TFT-LCD through Automatic Gamma Correction (Automatic Gamma 보정으로 인한 중소형 TFT-LCD의 최적화 연구)

  • Min, Byung-Chan;Yi, Jun-Shin;Kwag, Jin-Oh;Lee, Kon-Ho
    • Proceedings of the KIEE Conference
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    • 2006.07d
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    • pp.2051-2052
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    • 2006
  • 본 연구는 HHP,PDA,PMP,CNS 등등에 사용되는 중소형 A-Si:H TFT LCD 에서의 Automatic Gamma Correction 적용으로 화질 최적화 구현에 좀 더 쉽고 빠르게 접근하게 되었다. Analog Gamma String 대신 1chip Drive IC에 집적된 Gamma resister Ladder를 A-Si:H TFT-LCD Panel 특성에 보다 정확하게 적용시키기 위해 새로운 알고리즘을 개발 했으며 이를 적용시킨 회로를 Test Board로 실제 구현해서 최종결과를 도출하였다. Kick-Rack 전압을 고려한 Asymmetry-Gamma Correction 구현까지 Automatic으로 1chip Drive IC의 Register를 산출 할 수 있도록 알고리즘을 구성했다.

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A Study on Gamma Dose Rate in Seoul(I) (서울시내 공간 감마선량률 조사(I))

  • Kim, You-Hyun;Kim, Chang-Kyun;Choi, Jong-Hak;Kim, Jeong-Min
    • Journal of radiological science and technology
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    • v.24 no.1
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    • pp.61-65
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    • 2001
  • This study was conducted to find out gamma dose rate in Seoul, from January to December in 2000, and the following results were achieved ; 1. The annual gamma dose rate in Seoul was $17.24{\mu}R/hr$ as average. 2. The annual gamma dose rate in subway of Seoul was $14.96{\mu}R/hr$ as average. 3. The highest annual gamma dose rate was Dong-daemon ku. 4. Annual gamma dose rate in Seoul was higher autumn than winter.

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Effect of Gamma-Irradiation on the Molecular Properties of Blood Plasma Proteins

  • Song, Kyung-Bin;Lee, Seunghwan;Lee, Seunghyun
    • Preventive Nutrition and Food Science
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    • v.7 no.2
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    • pp.184-187
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    • 2002
  • Blood products from slaughterhouses that are not hygienically prepared for disposal or food consumption pose a human health hazard. Gamma irradiation is an effective method for sterilization of blood products, but may introduce changes in the molecular characteristics of proteins. This study evaluated the effects of irradiation on animal plasma proteins. Bovine and porcine blood was obtained from a slaughterhouse and the plasma proteins purified and lyophilized. The secondary structure and molecular weight distribution of the plasma protein solutions and powders were examined after ${\gamma}$-irradiation at 1, 5, 7 and 10 kGy. Gamma-irradiation affected the molecular properties of the protein solutions, but not the protein powders. Circular dichroism and sodium dodecyl sulfate-polyacrylamide gel electrophoresis studies showed that increased doses of ${\gamma}$-irradiation decrease the ordered structure of plasma proteins in solution, and cause initial fragmentation of the polypeptide chains and subsequent aggregation.

Effects of Low Dose Gamma Radiation on the Root Growth of Soybean Cultivars

  • Yoon, Young-Man;Cho, Hyung-In;Chang, Sung-Hee;Kim, Nam-Bum;Kim, Jae-Sung;Kim, Jeong-Gyu
    • Korean Journal of Environmental Agriculture
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    • v.19 no.5
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    • pp.394-400
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    • 2000
  • ${\gamma}-Radiation$ at very low doses frequently has a stimulating or hormetic effect on the growth of organism. Effects of low dose ${\gamma}-ray$ irradiation on the root growth of soybean cultivars were investigated and hormetic effects by environmental conditions were compared with the occurrence of increased economic yield, seeds of cultivars were irradiated with the dose of $0.5{\sim}20Gy$ and cultivated in growth chamber controling temperature, humidity, light, greenhouse and field respectively. To understand hormetic effect on root growth of cultivars and the difference of hormetic effect by cultivation environment, harvested root of soybean cultivars were scanned with image file, and root surface area, root length, root average diameter etc. were examined by WinRhizo program. Also, dry weight of cultivars was examined. Root growth and dry weight of soybean cultivars showed apparently hormetic effect at cultivation of growth chamber condition. In field experiment executed for whole life cycle, yields of pea were not different significantly in each ${\gamma}-ray$ irradiated cultivars but weight of one hundred peas increased in whole ${\gamma}-ray$ irradiated cultivars. Increment of yield was assumed to be induced through shortening of maturing stage caused by ${\gamma}-ray$ hormesis in early growth stage.

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