• Radiation Oncology Journal
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• 제30권3호
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• pp.124-131
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• 2012

Purpose: To determine whether triple negative (TN) early stage breast cancers have poorer survival rates compared with other molecular types. Materials and Methods: Between August 2000 and July 2006, patients diagnosed with stage I, II early stage breast cancers, in whom all three markers (estrogen receptor, progesterone receptor, and human epidermal growth factor receptor [HER]-2) were available and treated with modified radical mastectomy or breast conserving surgery followed by radiotherapy, were retrospectively reviewed. Results: Of 446 patients, 94 (21.1%) were classified as TN, 57 (12.8%) as HER-2 type, and 295 (66.1%) as luminal. TN was more frequently associated with young patients younger than 35 years old (p = 0.002), higher histologic grade (p < 0.0001), and nuclear (p < 0.0001). The median follow-up period was 78 months (range, 4 to 130 months). There were 9 local relapses (2.0%), 15 nodal (3.4%), 40 distant metastases (9.0%), and 33 deaths (7.4%) for all patients. The rates of 5-year OS, DFS, LFS, and DMFS for all patients were 95.5%, 89.9%, 95.4%, and 91.7%, respectively. There were no significant differences in OS, DFS, LFS, and DMFS between triple negative and other subtypes (p > 0.05). Conclusion: We found that patients with TN early stage breast cancers had no difference in survival rates compared with other molecular subtypes. Prospective study in homogeneous treatment group will need for a prognosis of TN early stage breast cancer.

• 한국학교보건학회지
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• 제19권2호
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• pp.117-125
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• 2006

Purpose : The purpose of this study is to test the effect of the web-b ased alcohol preventive education for ndicate the model of alcohol preventive education for students spreading al over the family and the comunity.Methods : This study was performed on the 1 public and 1 private eleme ntary school students who are the six grade in Seongdong-gu, Seoul. The number of experimental gr oup was 117 and control group's number was 131, totaled 248. eeks. The pre- and the post-test for web-based alcohol preventive education were tested about knowle dge and attitude toward drinking by questionnaire. The data analysis was done using SPS/Win 12.0 p rogram.Results：The results of this study are as follows;1. Compared with control group, experimental group which was educated the web-based alcohol preventive icant diference in the knowledge toward drinking.2. Compared with control group, also the experimental group w as improved with significant diference in attitude toward drinking after the education.3. In control group, female students' knowledge of drinking w as more increased than male students. And the he group which experienced drinking.Conclusions : The web-based alcohol preventi ve education is worth as a int ervention to get positive influence for the health education. Especially in female studen ts who didn't met with drinking, early education for alcohol prevention is very important. Therefore i t will be helpful that coperate with district ofice ithin the comunity for becoming established the controled drinking pattern.

• 한국안전학회지
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• 제31권1호
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• pp.126-131
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• 2016

Although many studies have been conducted to find solutions to deal with human errors effectively, violations have been rarely studied in depth. The violation is a type of human error when an employee takes an action with intention but does not intend harmful outcomes. Violations have characteristics similar to other types of human errors but it is difficult to understand the intention of an employee from accident reports. The objective of this study is to develop a conceptual model of violation errors for preventing accidents/failures in a nuclear power plant from violation errors. Based on the previous studies, the characteristics of violations were collected in 9 categories and 136 items. They were classified into three-kinds of characteristics (human-related, task-related, organization-related characteristics) to construct conceptual models of routine/situational violations. The representative cases of accidents/failures in a nuclear power plant were analyzed to derive the specific types of routine/situational violation occurrence. Three types of conceptual model for each violation were derived according to whether the basic, human-related, and task-related characteristics are included or not. The conceptual models can be utilized to develop guidelines to support employees preventing routine/situational violations and to develop supportive system in nuclear power plant.

• Asian Pacific Journal of Cancer Prevention
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• 제16권1호
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• pp.253-258
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• 2015

Background: Development of squamous cell cancer of head and neck (SCCHN) is associated with human papillomavirus (HPV) infection, which in turn is closely related with expression of $p16^{INK4A}$. Loss of $p16^{INK4A}$ expression by deletion, mutation, or hypermethylation is common in SCCHN. We here evaluated $p16^{INK4A}$ as a prognostic marker of treatment response and survival in our SCCHN patients with laryngeal, hypopharyngeal or nasopharyngeal cancers. Materials and Methods: 131 patients diagnosed with SCCHN between January 2,2006 and July 17, 2010 were examined for $p16^{INK4A}$. The median age was 60 years (15-82 years). Fifty one patients were stage I-II and 80 were stage III-IV. Immunohistochemical expression of $p16^{INK4A}$ was analyzed in pretreatment paraffin-embedded tumor blocks. The influence of $p16^{INK4A}$ status on disease-free survival, and overall survival after treatment was evaluated. Results: $p16^{INK4A}$ positivity was found in 58 patients (44%). Tumor-positivity for$ p16^{INK4A}$ was correlated with improved disease free survival (70.1 months vs 59 months) and improved overall survival (2, 3 and 5-year values; 77% vs 72%, 70% vs 63% and, 63% vs 55%; respectively). On multivariate analysis, stage was determined as independent prognostic factor for disease-free survival. Conclusions: Stage was the major prognostic factor on treatment response and survival in our patients. $p16^{INK4A}$ status predicts better outcome in laryngeal, hypopharyngeal or nasopharyngeal cancer cases treated with surgery plus adjuvant radiochemotherapy as well as with definitive radiation therapy and/or chemotherapy.

• Asian-Australasian Journal of Animal Sciences
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• 제31권10호
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• pp.1677-1684
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• 2018

Objective: To find biological functions such as antibacterial and antioxidant activities in several tropical plants and to investigate the possibility of antibiotic substitute agents to prevent and treat diseases caused by pathogenic bacteria. Methods: Plants such as Poncirus trifoliata fruit (Makrut), Zingiber officinale Rosc (Khing), Areca catechu L. (Mak), Solanum melongena L. I (Makkhuayao), and Solanum melongena L. II (Makhurapro) were extracted by methanol, n-hexane, chloroform, ethyl acetate, butanol and water. The free radical scavenging activities were measured using 2-diphenyl-2-picryl hydrazyl photometric assay. Antibacterial activities with a minimum inhibitory concentration (MIC) were observed by agar diffusion assay against pathogenic strains of Escherichia coli, Burkholderia sp., Haemopilus somnus, Haemopilus parasuis, Clostridium perfringens, and Pantoea agglomerans. Results: Poncirus trifoliata fruit methanol extract showed antibacterial activities against gram-negative and gram-positive pathogens. Additionally, this showed the strongest antibacterial activity against Burkholderia sp. and Haemopilus somnus with MIC $131{\mu}g/mL$, respectively. Areca catechu L. water extract showed antibacterial activities against Burkholderia sp., Haemopilus somnus, and Haemopilus parasuis. The MIC value for Haemopilus parasuis was $105{\mu}g/mL$ in this. Antioxidant activity of Zingiber officinale Rosc n-hexane extract showed 2.23 mg/mL effective concentration 50% ($EC_{50}$) value was the highest activity among tropical plants extracts. Total polyphenol content in Zingiber officinale Rosc methanol extract was $48.4{\mu}g/mL$ and flavonoid content was $22.1{\mu}g/mL$ showed the highest values among tested plants extracts. Conclusion: Taken together, these results suggest that tropical plants used in this study may have a potential benefit as an alternative antibiotics agent through their antibacterial and antioxidant activities.

• 대한한의학원전학회지
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• 제22권3호
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• pp.107-131
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• 2009

After having comparison, the Bunchon-ga in nine books -"Chimguchwiyeong(鍼灸聚英)", "Nengmunjeonsudong-injihyeol(凌門傳授銅人指穴)", "Chimgumundae(針灸問對)", "Gyeongrakgo(經絡考)", "Gyeongrakhoepyeon(經絡匯編)", "Geumchimbijeon(金針秘傳)", "Jagusimbeop-yogyeol(刺灸心法要訣)", "Chimgubongwon(鍼灸逢源)" "Chimgusinseo(鍼灸神書)", and invested the difference based on "Chimguhak(鍼灸學)", "WHO standard acupuncture point location" I got some conclusion like below. Two kinds of Bunchon-ga are similar in "Chimguchwiyeong", "Nengmunjeonsudong-injihyeol", and also in "Gyeongrakgo(經絡考)", "Gyeongrakhoepyeon(經絡匯編)", and "Geumchimbijeon(金針秘傳)" Bunchon-ga of twelve meridian is different from their order - Stomach meridian(胃經), Bladder meridian(膀胱經), Kidney meridian(腎經), Triple Energizer meridian(三焦經), and Gallbladder meridian(膽經). In nine kinds of Bunchon-ga, missing acupuncture points(漏落穴) are generally located on the first line of Bladder meridian(膀胱經) - from Daejeo(大杼) to Baekhwansu(白環兪), and Pungsi(風市), Haegye(解谿), Yangsi(羊矢), Geummaek(急脈) are not appeared in them, Hyeopdang(脇堂), Michung(眉衝), Yanghyeol(陽穴) are recorded. There are some parts adapted different way of proportional bone chon - from Yanggok(陽谿) to Gokji(曲池) in Large Intestine meridian[大腸經], from Sanggu(商丘) to Umreungcheon(陰陵泉) in Spleen meridian[脾經], and from Oegwan(外關) to Sadok(四瀆) in Triple Energizer meridian[三焦經]. The acupuncture points explained by structure, there are many different finger chons between some books. Bunchon on breast and abdomen, is generally explained by vertical, horizontal finger chon based on Governor vessel[任脈], vertical explanations of each book have little difference opinions, but horizontal have many. Especially, the locations of Eunmum(殷門), Bukeuk(浮郄) and Wiyang(委陽) are extremely different from "Chimguhak(鍼灸學)", and "WHO standard acupuncture point locations".

• 벤처창업연구
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• 제6권3호
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• pp.131-146
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• 2011

본 연구는 가정폭력 가해자들을 위한 가해자 교정상담 프로그램에 대한 효과에 대하여 분석하였다. 연구내용은 전국가정폭력 상담소 가해자 교육대상자와 전국 가정폭력 상담소 협의회, 한국여성의 전화 전화연합, 한국가정법률상담소 미 전국지부와 법원위탁 가정폭력 가해자 상담기관에서 상담 받은 가정폭력 가해자들이다. 연구결과는 부모로부터 받은 아동기 학대 경험이 적을수록 교육에 효과가 높게 나타났다. 둘째, 도시에 거주하는 가해자의 만족도가 높게 나타났다. 이는 정보와 교육수준이 높아 이해력이 높기 때문이다. 셋째, 교정상담 프로그램중에서 부부상담 프로그램 만족도가 높게 나타났다. 넷째, 교정상담 적용 프로그램중 여성주의 모델이 가장 만족도가 높게 나타났다. 가정폭력 가해자 교육중에 여성주의 상담과 여성주의 모델은 교정상담에 만족도에 큰 영향을 주고 있음을 알 수 있다.

• 한국수자원학회:학술대회논문집
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• 한국수자원학회 2011년도 학술발표회
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• pp.31-31
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• 2011

해마다 반복되는 수해를 대비하여 배수펌프장을 설치하고, 취수보를 철거하는 방법으로 수해예방시스템을 고도화 시키고 있지만, 증가하는 홍수량에 대한 대비책으로는 역부족이다. 따라서, 홍수 피해에 대한 선제적 대응방안으로 강변저류지를 설치하여 상습 침수구역에 대한 대비가 진행되고 있다. 강변저류지 설치를 통해 유역의 홍수량을 분담하고 인접지역의 침수피해를 예방하는 역할을 기대할 수 있다. 국내에서도 영월군의 상습침수구역에 대한 대비책 중 하나로 국토해양부 및 강원도가 함께 영월강변저류지 조성공사를 추진하고 있다. 영월군은 지난 2002년과 2003년에 태풍 '루사'와 '매미'로 인해 심각한 피해를 입었으며, 2006년 집중호우시에도 현재 저류지 예정지역인 방절리 일대와 영월읍 시가지, 북쌍리 등이 대규모로 침수피해를 입은 바 있다. 해당 저류지의 총 넓이는 68만 8천 $m^2$로 물 290만 $m^3$을 가두어 둘 수 있는 규모이다. 하지만, 영월 강변저류지의 저류용량이 290만 $m^3$에 불과해 홍수예방 효과가 미흡하다는 지적이 잇따르고 있다. 따라서, 적절한 수문운영을 통해 홍수저감량과 저류효과를 증대시키는 홍수예방 방안을 제안하고자 한다. 본 연구에서는 유전알고리즘의 적용을 통하여 강변저류지에 설치된 수문의 운영 방법을 개선함으로써 홍수저감량을 최대화하고자 하였다. 수리 수문학적 모형인 HEC-RAS, HEC-I 모형을 연계 운용하여 평창강 유역을 대상으로 수문분석, 홍수유출량 분석, 하류 하천의 홍수영향 분석 결과를 도출하였다. 강변저류지 설치로 인하여 저류지 직하류부를 기준으로 약 $131\;m^3/s$의 첨두홍수량 저감 효과가 발생하는 것으로 검토되었지만, 본 연구에서 제안된 최적화 기법이 적용된 수문운영 방법을 병행하여 운영한다면 추가적으로 $24\;m^3/s$를 저감하는 효과를 얻을 수 있다. 효율적으로 저류지를 운영하여 홍수피해를 사전에 방지하고 나아가 다른 저류지 유역에도 본 연구를 적용하여 홍수피해를 줄이고 합리적으로 용수를 이용하는데 기여할 수 있을 것으로 사료된다.

• 한국실내디자인학회논문집
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• 제18권4호
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• pp.124-131
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• 2009

The aesthetics of current dermatology clinics are the main space of dermatology, which is gradually becoming an area of specialty. Paths requiring spatial transition due to the expansion of treatment field in dermatology clinics are currently emerging, meaning that the duty to provide medical and aesthetic environment with high spatial connection must be accompanied. Contrary to past clinics where only functional aspects were emphasized, current clinics require a differentiated environment that considers both aspects of function and aesthetics, centered on the patient. The purpose of this research in this perspective is to study the efficient connection between dermatology and aesthetics, while also analyzing identity factors to indicate design factors differentiated from other functional spaces, to apply them as preliminary data for the planning of dermatology clinics. Based on the above, six dermatology clinics located in Seoul were designated for case studies through field studies. Overall, Aesthetics connected to dermatology clinics legally must have separate business registrations and have alternative entrance ways. Currently however, there were many cases where entrance, waiting, reception and receipt were not separated. there were efforts to partially display identities when analyzing design factors that formed the identity of dermatology clinics. However, there were insufficient cases where visual communication factors such as a clinic's spatial identity, logo, signing system, and applied products were integrated into a coherent theme. At this point when dermatology clinics are becoming brands, all fields must merge for integrated identity effects that go beyond the boundaries of contemporary H.I, to clearly display their identity with the clinics' professional image and consistent concept.

• 재무관리연구
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• 제1권1호
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• pp.119-131
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• 1985

Although Korea is short of capital technology, and natural resources, she has achieved an outstanding progress by the export-drive policies by Korean government and the creative endeavor of Korean firms. As a result of that, Korean economy and enterprises are in the same file of newly industrialized countries and Korea is ready for an economic take-off as a developed country. But in the early 1980s, each country strengthens protective trade theory and resources nationalism, and this has a great influence on the field of international trade environment. In spite of that, to continue the same high development as that of the past. Korea must try to secure and find export markets, solve trade barriers, make sure of the long-term security of resources, develop technology, and strengthen economic cooperations. To satisfy these desires by 2000s, we must try to make Korean enterprises have the global competitive power and them grow strongly among world wide firm through capital and technology accumulated during the passed years, and to do so, there must be a foreign production and marketing management, too, this can be achieved only through foreign overseas direct investment. This investment has various forms, to say, verifical integrated, horizontal integrated. conglomerate integrated forms, and the amount of investment in each country from 18 century to today reaches 500 billion dollars. This investment is done by strategic, behavioral economic, and financial motives. So I am going to approach the fields of like these; in spite of the differences among political, economical, caltural, and social systems, and many risk compared with domestic enterprises, why do Korean firms witsh to transfer the productive facilities to overseas countries and run them there? What is the comparative advantage of foreign direct investment compared with domestic investment ?. why is the factor of comparative advantage transferred through foreign direct investment?, what is the motive of foreign overseas direct investment?, and last the ownership-specific factors and the theory of internalization, and the location specific factors were analysed chiefly. But in consideration of the given condition in Korea, Korean overseas direct investment must be propelled rationally on the basis of the above mentioned theory.