• BMB Reports
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• v.50 no.10
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• pp.485-486
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• 2017

Many intrinsically unstructured/unfolded proteins (IUPs) contain transient local secondary structures even though they are "unstructured" in a tertiary sense. These local secondary structures are named "pre-structured motifs (PreSMos)" and in fact are the specificity determinants for IUP-target binding, i.e., the active sites in IUPs. Using high-resolution NMR we have delineated a PreSMo active site in the intrinsically unfolded mid-domain (residues 201-300) of SUMO-specific protease 4 (SUSP4). This 29-residue motif which we termed a p53 rescue motif can protect p53 from mdm2 quenching by binding to the p53-helix binding pocket in mdm2(3-109). Our work demonstrates that the PreSMo approach is quite effective in providing a structural rationale for interactions of p53-mdm2-SUSP4 and opens a novel avenue for designing mdm2-inhibiting anticancer compounds.

• The Journal of Asian Finance, Economics and Business
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• v.7 no.4
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• pp.121-131
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• 2020

This study aims to investigate the interplay between education and local roads on Foreign Direct Investment (FDI) in the Philippines, using economic growth as an instrument. The study used the quantitative research design applying both descriptive and inferential statistics. A combination of Two Stage Least Square Regression Model and three approaches in Panel Regression Model such as Pooled Least Square, Fixed Effect Model, and Random Effect Model were utilized in order to study the effects of education and local roads on foreign direct investment of the Philippines. Based on Fixed Effect regression results, higher education graduates and local road investments, as conditioned by economic growth, were significant factors in order to increase the foreign direct investment in the Philippines. Accordingly, a unit increase in higher education graduates, as conditioned by economic growth, leads to 8.758 unit increases in the foreign direct investment. While, a unit increased in local road investments, as conditioned by economic growth, leads to a 0.002 decrease in foreign direct investment. The regression results of the study suggest that the Foreign Direct Investment in the regions such as CAR, I, II, IV-B, V, VIII, IX, X, XI, XII, XIII, and ARMM are higher compared to Region IV-A.

• Journal of the Korea Computer Industry Society
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• v.8 no.2
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• pp.131-140
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• 2007

The rapidly expanding field of animation is constantly looking for skilled animators in both 2D and 3D applications. The animation industry, as little as 10 years ago, was limited to the occasional blockbuster release. Today, we find animation everywhere, from medical applications to architecture to feature films and gaming, Especially, 3D games have become a way of life, but it still requires a lot of effort, on the programming side, to get it looking respectable. Programmers take a much more charge of part than designersin the real life game production. In this paper, I would analyze how to easily create 3D game animation using Virtools even if you are a non-programmer.

• Journal of Biosystems Engineering
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• v.25 no.2
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• pp.131-140
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• 2000

Spraying operation is one of the most essential in an orchard management and it is also hazardous to human body. for automatic and unmanned spraying , an autonomous travelling vehicle is demanded. In this study, a telemeter was developed using infrared beam which could detect trunks and obstacles measure distance and direction from the vehicle travelling in the orchard. The telemeter system was composed of two infrared LED transmitters and receivers, a beam scanning device for continuous object detection , two rotary encoders for angle detector, and a beam level controller for uneven soil surface. The detected distance and direction signal s were sent to personal computer which made for the system display the angular and distance measurements through I/O board. According to a field test in an apple farm, the system detected up to 10m distance under 12 V of transmitted beam intensity, however, it was recommended that the proper beam transmit intensity be 7 v at the 10 m distance, because of the negative effect to human body at 12 V. The error rate of this system was 0.92 % when the actual distance was compared to measured one. The system was feasible at the small error rate. The developed telemeter system was an important part for autonomous travelling vehicle provided the real time object recognition . A direction control system could be constructed suing the system. It is expected that the system could greatly contribute to the development of autonomous farm vehicle.

• The Korean Journal of Nuclear Medicine
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• v.12 no.2
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• pp.41-46
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• 1978

8 cases of subacute thyroiditis was diagnosed among 108 needle biopsy of the thyroid during the period from April 1976 to August 1978. Correlation of the histologic findings with the clinical staging proposed by Czernick was relatively well matched; cases with long clinical course or low thyroid hormone levels showed greater fibrosis and reduction of follicular elements in thyroid. Thyroid $^{131}I$ uptake or the uptake as seen on the thyroid scanning correlated inversely with the thyroid hormone levels. The clinical course of the patients seen in their initial stage of disease followed the classical pattern; hyperthyroid-like, hypothyroid-like and recovery. 3 among the 4, who were seen in their later clinical course showed hypothyroidism, which seemed the final outcome of their diseases.

• The Korean Journal of Nuclear Medicine
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• v.24 no.2
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• pp.293-298
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• 1990

We performed 17 intraarterial scintigraphies in six patients with recurrent cervix cancer. With Seldinger method, the agent (four different radiopharmaceuticals) was perfused at the same speed of infusion of anticancer drugs (25 cc/hour) through internal iliac artery. There were four different radiopharmaceuticals; I-131-Lipiodol, Tc (Technetium)-99m-HSa (Human Serum Albumin), $^{99m}Tc-Sucralfate$ and $^{99m}Tc-MAA$ (Macroaggraegated Albumin). We evaluate the distribution pattern of radioactivity by the use of ratio of Tumor/Extratumor uptake (T/ET ratio). Our results reveals that $^{99m}Tc-MAA$ scan showed the highest T/ET ratio and the other were not ideal agents for intraarterial therapy of recurrent cervix cancer. In conclusion, an ideal radioisotope and tracer which can block capillary, for example MAA, should be re-evaluated or produced in order to treat the patient with recurrent cervix cancer.

• Journal of The Korean Society of Grassland and Forage Science
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• v.8 no.3
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• pp.68-76
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• 1988

The variation of rumination response in steers fed a same amount of orcharugrass hay was investigated. With three steers (6, 12, 24 months) of the Japanese Black Breed, rumination behaviour was measured continuously during a 5 days period by masseter EMG telemetry system. The results are summarized as follows: 1. The average daily rumination time of respective animals were 438,447 and 433 min. with small daily variation both within and among animal. But the rumination time per DM kg of hay consumed varied from 66 to 138 min., and calf spent longer than older calf. 2. Actural chewing time showed small variation, and percentage of actural chewing time spent in rumination time was from 88 to 93% on individual average. 3. The daily number of chewing in rumination was approximately 25,000 to 30,000 with large individual differences. The chews per DM kg intake varied from 3,800 to 9,600, and calf chewed more than older calf. 4. The average rate of chewing per 100 sec. (chewing speed), there was a large difference between animals i.e. 104, 114, 131 respectively, but very little variance between days in individual. 5. No relation between day to day variations in eating time and rumination behavior, but significantly positive correlation was observed in the relation among rumination time, chewing time, No. of boluses and No. of chews. 6. Active time of day in rumination altered considerably day to day, but variation in the amount of rumination per day as expressed by the rumination time was relatively small.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2001.05c
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• pp.131-134
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• 2001

In this paper, the piezoelectric and dielectric properties as a function of x and a in $aPbZr_xTi_{1-x}O_3-(1-a)Pb(Mn_{1/3}Nb_{2/3})O_3$ + ywt%MgO is investigated. As a results, when a is 0.95 and x is 0.505, electromechanical coupling factor$(k_p)$, permittivity${\varepsilon}_33^T/{\varepsilon}_0$, piezoelectric strain constant$(d_{33})$ and mechanical quality factor$(Q_m)$ are 58 %, 1520, 272 pC/N and 1550, respectively. From XRD analysis, when x is 0.505, it is MPB which present rhombohedral and tetragonal phase in same quantity. Also, From SEM observation, when sintering temperature is $1150^{\circ}C$, grain size is about $2\;{\mu}m$. As a results added MgO dopant in the ternary piezoelectric ceramic, when MgO content is 0.1 wt%, $k_p$ increases to 63[%].

• Proceedings of the KOR-BRONCHOESO Conference
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• 1987.05a
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• pp.23.1-23
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• 1987

1985년 1월부터 1986년 12월까지 전북의대 부속병원 이비인후과에 입원하여 수술치료를 받은 34예의 갑상선 결절을 가진 환자를 대상으로 임상분석을 실시하여 다음과 같은 결과를 얻었다. 1) 34례중 32례(94.1%)가 양성, 그리고 2례(5.9%)가 악성 결절이었다. 2) 성비는 33 : 1로 여성에서 월등히 많았다. 3) 20-40대가 25명(73.5%)였고, 40대가 11명(32.4%)로 가장 많았다. 4) 이병기간은 3개월 이내가 14명(41.1%)으로 가장 많았다. 5) 임상증상에서 결절 촉진 34례(100%), 피로감 6례(18%) 심계항진 5례(15%)순이었다. 6) 발생부위에서는 우엽 21례(62%), 좌엽 10례(29%), 양엽 2례(6%) isthmus 1례(3%)순이었다. 7) $I^{131}$섭취검사에서 73.9%가 정상범위였으며, 갑상선주사소견에서는 cold결절이 91.3%였다. 8) 병리조직학적 분류를 보면 양성에서는 adenema 24례(75%), adenomatous goiter 5례(16%), cyst 3례(9%)순이었고 악성 2례는 papillary earcinoma 였다. 9) 수술방법은 일측성 편엽절제술이 22례(64.7%)로 가장 많았다. 10) 수술후 합병증은 경도의 출혈이 5례(14.7%)였고, 다음이 일시적 사성 3례(8.8%)이었다.

• Asian Oncology Nursing
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• v.7 no.2
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• pp.131-139
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• 2007

Purpose: This study was to compare the perceptions about hospice and the meaning of life between the participants and non-participants of the hospice volunteer education program. Method: Descriptive survey research design was used. Participants were 63, and the data collecting period was from October to December, 2006. Instrument developed by Jung-Hee Kim(1990) and Eun-Ja Lee(1998) was modified to measure the perceptions about hospice. To measure the meaning of life, P.I.L (Purpose In Life) instrument by Crumbaugh and Maholick(1969) was utilized. The data were analyzed using $X^2-test$, t-test and Pearson-Correlation Coefficient. Results: 1. The participants in the hospice volunteer education program demonstrated higher perception scores about hospice than the non-participants (t=5.193, p= .001). 2. The program participants also showed higher scores of the meaning of life than non-participants (t=3.084, p=.005). 3. The perception about hospice and the meaning of life had positive correlation (r= .46, p= .01). Conclusion: Therefore, hospice education program must be established in a continual and systematic way in order to standardize the hospice system in Korea.