• Biomedical Science Letters
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• v.15 no.1
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• pp.61-66
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• 2009

Leflunomide is an immunomodulatory agent used for the treatment of rheumatoid arthritis (RA). Leflunomide known as a regulator of iNOS synthesis which largely decreases NO production in diverse cell type. However, the effect of leflunomide on chondrocyte is still poorly understood. In our previous studies, we have shown that direct production of Nitric oxide (NO) by treating chondrocytes with NO donor, sodium nitroprusside (SNP), causes apoptosis via p38 mitogen-activated protein kinase in association with elevation of p53 protein level, caspase-3 activation. In this study, we characterized the molecular mechanism by which A77 1726 inhibit apoptosis. We found that A77 1726 inhibit NO-induced apoptosis as determined by MTT (Thiazolyl Blue Tetrazolium Bromide) assay and DNA fragmentation. The inhibition of apoptosis by A77 1726 was accompanied by increased PI-3 kinase and AKT activities. So, inhibition of phosphatidylinositol (PI)-3kinase with LY294002 rescued apoptosis. Triciribine, the specific inhibitor of AKT, also abolished anti-apoptotic effect. Our results indicate that A77 1726, the active metabolite of leflunomide, mediates NO-induced apoptosis in chondrocytes by modulating up-regulation of PI-3 kinase and AKT.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.12 no.3
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• pp.17-24
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• 1992

It would be much effective that single column type pier is used in concrete slab bridges rather than ${\Pi}$ or gravity type pire is used. To determine the longitudinal benging moment in concrete slab bridges supported by single column type piers, the concept of effective width is applied. By elastic plate theory cooperated with finite element method, the distribution of the longitudinal moment of the slab supported by single column type piers is studied. The main variables are span, width. thickness of the slab, and column section size. The analytical results obtained are summarized and analysed to evaluate the maximum longitudinal negative moment, then a simplified method for calculating the longitudinal moment is proposed.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2002.11a
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• pp.888-892
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• 2002

In this paper, parallel type fuzzy controller is designed by using a hybrid connected type fuzzy-PID controller and a model reference fuzzy controller. The first controller that consists a fuzzy-PI and a fuzzy-PD making a hybrid type fuzzy-PID controller plays a role as firstly reaching stable responses and secondly overcoming disturbance in plants. The second controller, model reference fuzzy controller, plays a role as reaching faster responses than other controllers. We have confirmed that we get rapid and stable responses and the controller overcomes disturbance in a short time when there happens disturbance by using parallel type fuzzy controller applying to DC motor in this paper.

• Proceedings of the International Microelectronics And Packaging Society Conference
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• 2003.11a
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• pp.181-184
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• 2003

Low Energy High flux Plasma Source인 Stationary Plasma thruster (SPT)를 이용하여 폴리이미드의 표면개질 후 접촉각과 표면에너지의 변화를 조사하고 접착력과의 관계를 조사하였다. 이온에너지는 180 eV - 200 eV, 이온전류 밀도는 수백 ${\mu}A/cm^2$, 이온선량은 $5\times10^{15}/cm^2$부터, $10\times^{18}/cm^2$로 $Ar^+,\;N_2^+,\;O_2^+$를 이온 주입시켰다. 표면 처리된 폴리이미드에 대한 접촉각 변화는 dual contact anglemeter로 증류수와 에틸렌글리콜을 이용하여 측정하였고, 표면에너지의 변화량을 구하였다. 접촉각의 변화는 아르곤 이온의 경우는 최저 $35^{\circ}$, 질소와 산소의 경우 $1\times10^{17}/cm^2$에서 각각 $14^{\circ},\;10^{\circ}$정도의 전촉각을 보였으며, $5\times10^{17}/cm^2$이상에서는 측정하기 불가능하였다. 산소 이온빔으로 처리된 PI의 표면을 x-ray photoelectron spectroscopy를 통하여 측정하여본 결과, 친수성기가 많이 형성되었음을 확인할 수 있었다. 접촉각 측정으르부터 PI의 표변에너지는 42.1 mN/m에서 아르곤 이온빔의 처리 시 65.2 mN/m로 산소 이온빔의 처리 시 81.2 mN/m로 각각 1.5배, 1.9배 정도 증대하였다. 산소 이온빔으로 처리된 PI 표면위에 스퍼터링으로 300 nm 정도의 clad layer 형성 후 $20{\mu}m$ 정도의 구리 전기 도금막을 형성하여, peel 강도를 측정한 결과 0.79 kg/cm의 강도를 얻을 수 있었다.

• Journal of Plant Biotechnology
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• v.37 no.1
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• pp.57-66
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• 2010

Programmed cell death systems are important for an active type of cell deaths. Among them, a type of programmed cell death, autophagy is activated in cancer cells in response to multiple stresses and has been demonstrated to promote tumor cell survival and drug resistance. Thus, in the area of cancer, over the time frame form around the 1940s to date, of the 155 small molecules, 73% are other than "synthetic", with 47% actually being either "natural products" or "directly derived therefrom". Autophagy has multiple physiological functions in multicellular organisms, including protein degradation and organelle turnover. Genes and proteins that constitute the basic machinery of the autophagic process were first identified in the yeast system and some of their mammalian orthologues have been characterized as well. Numerous oncogenes, including Akt1, Bcl-2, NF1, PDPK1, class I PI3K, PTEN, and Ras and oncosuppressors, inculuding Bec-1, Bif-1, DAPK-1, p53 and UVRAG suppress or promote the autophagy pathway. Regulation of autophagy in tumors is governed by similar principles of the normal cells, only in a much more complicated manner, given the frequently observed abnormal PI3K activation in cancer and the multitude of interactions between the PI3K/AKT/mTOR pathway and other cell signaling cascades, often also deregulated in tumor cells. Autophagy induction by some anticancer agents underlines the potential utility of its induction as a new cancer treatment modality of development for natural medicines.

• Journal of Energy Engineering
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• v.10 no.3
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• pp.253-265
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• 2001

This paper investigates a PI control problem for the evaporator superheat, i.e., temperature difference between the two-phase region and the exit region of an evaporator, for multi-type air-conditioning/refrigeration system. Mathematical model describing the characteristics of compressor, condenser, evaporator, and electronic expansion valve are first derived. Then, two transfer function from the current input applied to an electronic expansion valve to the wall-temperatures of an evaporator tube at two-phase region and superheated region, respectively, are derived. The stability of the closed loop system with the PI controller designed it analyzed by using Nyquist stability criterion. Simulation results are provided.

• Bulletin of the Korean Chemical Society
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• v.34 no.11
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• pp.3211-3217
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• 2013

Density functional theory (DFT) and time-dependent DFT (TD-DFT) calculations have been employed to investigate the molecular structures and absorption spectra of three D-${\pi}$-A-type organic dyes (C1-1, D5 and TH208) containing identical ${\pi}$-spacers and electron acceptors, but different aromatic amine electron-donating groups (tetrahydroquinoline, triphenylamine and phenothiazine). The coplanar geometries indicate that the strong conjugation is formed in the dyes. The electronic structures suggest that the intramolecular charge transfer from the donor to the acceptor occurs, and the electron-donating ability of tetrahydroquinoline is stronger than those of triphenylamine and phenothiazine. The computed orbital energy levels of these dyes confirm that the electrons could be injected from the excited dyes to the semiconductor conduction band and the oxidized dyes could be reduced effectively by electrolyte. The TD-DFT results show that the CAM-B3LYP/6-31+G(d, p) is suitable for calculating the absorption spectra. The first absorption band for these dyes is assigned to the HOMO${\rightarrow}$LUMO and HOMO-1${\rightarrow}$LUMO transitions.

• The Transactions of the Korean Institute of Power Electronics
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• v.10 no.1
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• pp.29-37
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• 2005

This paper presents a tuning-free conditional integration anti-windup strategy for induction machine with Proportional-Integral(PI) type speed controller. The on/off condition of integral action is determined by the frequency domain analysis of machine torque command without a prior knowledge of set-point changes. There are no tuning parameters to be selected by users for anti-windup scheme. In addition, the dynamic performance of the proposed scheme assures a desired tracking response curve with minimal oscillation and settling time even in the change of operating conditions. This algorithm is useful in many high performance induction machine applications not to allow the oscillation and overshoot of speed/torque responses. The main idea can be extended to general applications such as chemical processes and industrial robots.

• 제어로봇시스템학회:학술대회논문집
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• 2004.08a
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• pp.227-231
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• 2004

In this paper, a robust Sliding Mode Variable Structure (SMVS) controller is designed for Active Queue Management (AQM). This type of controller is insensitive to noise and variance of the parameters, thus it is suitable to time varying network systems. Simulation results conform the robust performance of SMVS controller against the disturbance. At the same time, a complete comparison between SMVS and PI controllers is made. The conclusion is that both transient and steady state performance of SMVS controller is better than that of PI one.

• Bulletin of the Korean Mathematical Society
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• v.44 no.2
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• pp.351-358
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• 2007

For an entire function f whose Fourier transform has a compact support confined to $[-{\pi},\;{\pi}]$ and restriction to ${\mathbb{R}}$ belongs to $L^2{\mathbb{R}}$, we derive a nonuniform sampling theorem of Lagrange interpolation type with sampling points ${\lambda}_n{\in}{\mathbb{R}},\;n{\in}{\mathbb{Z}}$, under the condition that $$\frac{lim\;sup}{n{\rightarrow}{\infty}}|{\lambda}_n-n|<\frac {1}{4}$.