• 대한기계학회:학술대회논문집
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• 대한기계학회 2004년도 춘계학술대회
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• pp.1909-1914
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• 2004

An immersed boundary method for simulation of density-stratified flows is developed and applied to computation of viscous flows over two-dimensional obstacles in a bounded domain under stable density stratification. Density sources/sinks are introduced on the body surface. Two obstacle shapes are used, a vertical barrier and a smooth cosine-shaped hill; weak stratification, defined by $K=ND/{\pi}U{\leq}1$, where U, N, and D are the upstream velocity, buoyancy frequency, and domain height, respectively, is considered. The results are consistent with other authors' calculations, and shed light on computation of density-stratified flows in complex geometries.

• Psychiatry investigation
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• 제15권11호
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• pp.1011-1018
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• 2018

The analysis of extracellular vesicles has been accelerated because of the technological advancements in omics methods in recent decades. Extracellular vesicles provide multifaceted information regarding the functional status of the cells. This information would be critical in case of central nervous system cells, which are confined in a relatively sealed biological compartment. This obstacle is more dramatic in psychiatric disorders since their diagnosis primarily depend on the symptoms and signs of the patients. In this paper, we reviewed this rapidly advancing field by discussing definition of extracellular vesicles, their biogenesis and potential use as clinical biomarkers. Then we focused on their potential use in psychiatric disorders in the context of diagnosis and treatment of these disorders. Finally, we tried to combine the RDoC (Research Domain Criteria) with the use of extracellular vesicles in psychiatry research and practice. This review may offer new insights in both basic and translational research focusing on psychiatric disorders.

• 전기의세계
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• 제30권12호
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• pp.811-816
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• 1981

In this paper, the finite element method is applied to find the flux distribution of the magnetic field in the end region of the tubular motor. In order to analyze two-dimensional flux distribution, the r-z domain to be analyzed is subdivided into 56 nodes, 84 elements. In the case of wt=O and .pi./2, the flux distribution is shifted to the edge with frequency (w) and time (t) increase in the edge and the air gap. It is proved that this study does fit the actual phenomena.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 2000년도 제15차 학술회의논문집
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• pp.319-319
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• 2000

In this paper, A dead-time compensator (DTC) for the processes with long dead-time is proposed. The processes which consist of dead-time, time-constant, gain are estimated by the linear least squares method in the frequency domain. A Smith predictor(SP) modified by including a filter becomes a two degree of freedom DTC. So the proposed DTC can yield the desirable setpoint and load disturbance responses separately. PI controller is used for the primary controller and the filter is tuned to be robust. Simulation examples demonstrate the properties of the proposed DTC.

• 한국자기학회:학술대회 개요집
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• 한국자기학회 2007년도 동계학술연구발표회 및 스핀트로닉스와 나노물리에관한 국제심포지움
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• pp.88-88
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• 2007

• 한국자기학회:학술대회 개요집
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• 한국자기학회 2008년도 하계학술연구발표회
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• pp.109-109
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• 2008

• 대한수학교육학회지:학교수학
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• 제17권2호
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• pp.309-329
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• 2015

본 연구의 목적은 예비교사의 라디안에 대한 이해를 분석하여 라디안 지도에 대한 교수학적 시사점을 도출하는데 있다. 이를 위해 라디안의 개념과 속성, 교육과정 및 교과서를 분석한 후 이를 바탕으로 문항을 개발하였으며, 이를 예비교사 35명에게 적용하여 그 반응을 분석하였다. 분석 결과, 라디안을 정의보다는 ${\frac{180^{\circ}}{\pi}}$로 기억하는 학생들이 많았으며, 라디안의 정의를 어떻게 이해하고 있는지가 각의 측정문제의 해결전략에 영향을 미치고 있음을 확인하였다. 또한 예비교사들은 라디안의 이중적 의미, 특히 실수 속성에 대한 이해가 부족하였고, 삼각함수가 왜 실수에서 실수로의 함수로 정의되는지에 대해 적절하게 설명하지 못하였으며, 호도법의 필요성과 유용성을 매우 제한적으로 인식하고 있었다. 이상의 결과로부터 ${\frac{180^{\circ}}{\pi}}$를 1라디안으로 정의하는 교과서의 기술 방식이 개선되어야 한다는 것과 일반각이 실수와 일대일 대응임을 언급함으로써 삼각함수의 정의역이 실수임을 자연스럽게 이해하도록 할 것을 제안하였다.

• 한국전기전자재료학회:학술대회논문집
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• 한국전기전자재료학회 2008년도 춘계학술대회 및 기술 세미나 논문집 디스플레이 광소자
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• pp.41-41
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• 2008

In general, polyimides (PIs) are used in alignment layers in liquid crystal displays (LCDs). The rubbing alignment technique has been widely used to align the LC molecules on the PI layer. Although this method is suitable for mass production of LCDs because of its simple process and high productivity, it has certain limitations. A rubbed PI surface includes debris left by the cloth, and the generation of electrostatic charges during the rubbing induces local defects, streaks, and a grating-like wavy surface due to nonuniform microgrooves that degrade the display resolution of computer displays and digital television. Additional washing and drying to remove the debris, and overwriting for multi-domain formation to improve the electro-optical characteristics such as the wide viewing angle, reduce the cost-effectiveness of the process. Therefore, an alternative to non-rubbing techniques without changing the LC alignment layer (i.e, PI) is proposed. The surface of LC alignment layers as a function of the ion beam (IE) energy was modified. Various pretilt angles were created on the IB-irradiated PI surfaces. After IB irradiation, the Ar ions did not change the morphology of the PI surface, indicating that the pretilt angle was not due to microgrooves. To verify the compositional behavior for the LC alignment, the chemical bonding states of the ill-irradiated PI surfaces were analyzed in detail by XPS. The chemical structure analysis showed that ability of LCs to align was due to the preferential orientation of the carbon network, which was caused by the breaking of C=O double bonds in the imide ring, parallel to the incident 18 direction. The potential of non-rubbing technology for fabricating display devices was further conformed by achieving the superior electro-optical characteristics, compared to rubbed PI.

• Parasites, Hosts and Diseases
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• 제56권2호
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• pp.135-145
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• 2018

Due to the critical location and physiological activities of the retinal pigment epithelial (RPE) cell, it is constantly subjected to contact with various infectious agents and inflammatory mediators. However, little is known about the signaling events in RPE involved in Toxoplasma gondii infection and development. The aim of the study is to screen the host mRNA transcriptional change of 3 inflammation-related gene categories, PI3K/Akt pathway regulatory components, blood vessel development factors and ROS regulators, to prove that PI3K/Akt or mTOR signaling pathway play an essential role in regulating the selected inflammation-related genes. The selected genes include PH domain and leucine- rich-repeat protein phosphatases (PHLPP), casein kinase2 (CK2), vascular endothelial growth factor (VEGF), pigment epithelium-derived factor (PEDF), glutamate-cysteine ligase (GCL), glutathione S-transferase (GST), and NAD(P)H: quinone oxidoreductase (NQO1). Using reverse transcription polymerase chain reaction (RT-PCR) and quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR), we found that T. gondii up-regulates PHLPP2, $CK2{\beta}$, VEGF, GCL, GST and NQO1 gene expression levels, but down-regulates PHLPP1 and PEDF mRNA transcription levels. PI3K inhibition and mTOR inhibition by specific inhibitors showed that most of these host gene expression patterns were due to activation of PI3K/Akt or mTOR pathways with some exceptional cases. Taken together, our results reveal a new molecular mechanism of these gene expression change dependent on PI3K/Akt or mTOR pathways and highlight more systematical insight of how an intracellular T. gondii can manipulate host genes to avoid host defense.

• Molecules and Cells
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• 제41권12호
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• pp.1008-1015
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• 2018

$I{\kappa}B$, a cytoplasmic inhibitor of nuclear factor-${\kappa}B$ ($NF-{\kappa}B$), is reportedly degraded via the proteasome. However, we recently found that long-term incubation with proteasome inhibitors (PIs) such as PS-341 or MG132 induces $I{\kappa}B{\alpha}$ degradation via an alternative pathway, lysosome, which results in $NF-{\kappa}B$ activation and confers resistance to PI-induced lung cancer cell death. To enhance the anti-cancer efficacy of PIs, elucidation of the regulatory mechanism of PI-induced $I{\kappa}B{\alpha}$ degradation is necessary. Here, we demonstrated that PI up-regulates nuclear factor (erythroid-derived 2)-like 2 (Nrf2) via both de novo protein synthesis and Kelch-like ECH-associated protein 1 (KEAP1) degradation, which is responsible for $I{\kappa}B{\alpha}$ degradation via macroautophagy activation. PIs increased the protein level of light chain 3B (LC3B, macroautophagy marker), but not lysosome-associated membrane protein 2a (Lamp2a, the receptor for chaperone-mediated autophagy) in NCI-H157 and A549 lung cancer cells. Pretreatment with macroautophagy inhibitor or knock-down of LC3B blocked PI-induced $I{\kappa}B{\alpha}$ degradation. PIs up-regulated Nrf2 by increasing its transcription and mediating degradation of KEAP1 (cytoplasmic inhibitor of Nrf2). Overexpression of dominant-negative Nrf2, which lacks an N-terminal transactivating domain, or knock-down of Nrf2 suppressed PI-induced LC3B protein expression and subsequent $I{\kappa}B{\alpha}$ degradation. Thus, blocking of the Nrf2 pathway enhanced PI-induced cell death. These findings suggest that Nrf2-driven induction of LC3B plays an essential role in PI-induced activation of the $I{\kappa}B$/$NF-{\kappa}B$ pathway, which attenuates the anti-tumor efficacy of PIs.