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Effects of Mung Bean (Phaseolus aureus L.) on Blood Glucose and Lipid Composition Improvement in Streptozotocin-induced Diabetic Rats (녹두(Phaseolus aureus L.) 급여가 당뇨 유발 흰쥐의 혈당 및 지질성분 개선에 미치는 영향)

  • Bark, Si-Woo;Kim, Han-Soo
    • Journal of the Korean Applied Science and Technology
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    • v.37 no.2
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    • pp.162-172
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    • 2020
  • The purpose of this study was to investigate the improvement effect of 5% mung bean (phaseolus aureus L.) on the blood glucose and lipid metabolism function of streptozotocin (STZ, 45 mg/kg body weight)-induced diabetic rats. Seven-week-old male rats were divided into four groups (n=6), and fed experimental diets containing mung bean meal [basal diet+5% mung bean (BM), basal diet+STZ+5% mung bean (SM)], and control (BD), BS groups (basal diet+STZ). The results of this study, mung bean diet groups (BM, SM) in lipid composition evidenced the significantly reduction of serum total cholesterol, low density lipoprotein-cholesterol (LDL-cholesterol), atherosclerotic index (AI), cardiac risk factor (CRF), triglyceride (TG), phospholipid (PL), free cholesterol, cholesteryl ester, uric acid, blood glucose, non esterified fatty acid (NEFA), and elevation of high density lipoprotein-cholesterol (HDL-cholesterol). The serum albumin/globulin ratio (A/G ratio) was increased in mung bean supplementation diet than STZ-induced diabetic rats (p<0.05). Concentrations of sodium (Na) and chlorine (Cl) in sera were lower in the mung bean diet than diabetic group. Total calcium (T-Ca), phosphorus (Pi) and potassium (K) concentrations in sera were higher in the BM, SM and BD groups than BS group. In vivo experiments with Sprague-Dawley rats showed that ingestion of mung bean (phaseolus aureus L.) were effective in blood glucose and lipid composition.

Study on the Prototype of the Rear Garden in Changdeok Palace through Gang Sehwang's "Record of Strolling with King in the Forbidden Garden" (강세황의 "호가유금원기(扈駕遊禁苑記)"로 살펴본 창덕궁 후원의 원형경관 탐색)

  • Jung, Woo-Jin;Oh, Lee-Chun;Sim, Woo-Kyung
    • Journal of the Korean Institute of Traditional Landscape Architecture
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    • v.31 no.1
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    • pp.87-97
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    • 2013
  • This study was carried out to find the prototype of the rear garden in Changdeok Palace during King Jungjo's reign through Gang Sehwang's "Record of Strolling with King in the Forbidden Garden", and the site of this study included the whole areas of Ongnyucheon(玉流川), Mansongjeong(萬松亭), Mangchunjeong(望春亭), Jondeokjeong(尊德亭), Pyemwoosa and Taichungmun(太淸門). The characteristics of the area of Ongnyucheon described in Record of Strolling with King in the Forbidden Garden was the shape of Wiyiam expressed three-dimensional mountain such as the fence surrounding Soyojeong(逍遙亭) and the painting techniques of Fu Pi' ts'un and pond in front of Taegeukjeong(太極亭). The pond in front of Taegeukjeong(which was described by Gang Sewhang) is also identified in Donggwoldo(東闕圖) and this study judged that the pond was removed during the maintenance process of Ongnyucheon, where was scheduled as the place of entertainment when Chinggyong-Yesik(稱慶禮式: Royal court rites) was held to celebrate the 40th anniversary of King Gojong's reign. The characteristics of the whole area of Mangchunjeong where was the attraction point for flower viewing in the forbidden garden was surrounded by the sculptured fence, and Mangchunjeong which was hexagonal structure was located in the inside of the structure on both sides of the main building. The cornerstone was carved with white jade. Also a corridor assumed as Chunhyanggak(天香閣) was adjacent to Mangchunjeong. Gang Sehwang confirmed the space organization appeared in Donggwoldo by describing the attached building of Pyemwoosa, Taichungmun, and surrounding fence in detail.

Assessment of Pollution Level and Contamination Status on Mine Tailings and Soil in the Vicinity of Disused Metal Mines in Kangwon Province (강원도 폐금속광산지역의 광미와 주변토양의 중금속 오염현황 및 오염도 평가)

  • Kim, Joung-Dae
    • Journal of Korean Society of Environmental Engineers
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    • v.27 no.6
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    • pp.626-634
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    • 2005
  • The objectives of this study was to assess pollution level and contamination status on tailings and soil in the vicinity of four disused metal mines in Kangwon province. As the result of total metal concentrations analysis, the pollution degree of tailings and soil decreased in the order of Wondong > Second Yeonhwa > Sinyemi ${\fallingdotseq}$ Sangdong mines. Total metal concentrations of mine tailings in this study were $1.2{\sim}78.2$ and $1.1{\sim}80.6$ times higher than those in the background soil and the tolerable levels suggested by Kloke, respectively. From these results, we found that tailings served as contamination source of nearby soil. According to sequential extraction of metals, large proportion of heavy metals in all mine tailings existed in the form of a residual fraction, and heavy metals in non-residual form was mainly associated with Fe-Mn oxide fraction and sulfidic-organic fraction. Fe-Mn oxide fraction and sulfidic-organic fraction of heavy metals may be released into and contaminated the nearby environment under the oxidation or reduction condition in long-term. In particular, the proportions of the exchangeable and carbonate fraction of Cd in mine tailings from Second Yeonhwa mine were relatively high. This suggests that Cd may be easily released into and contaminated the nearby environment in the near time. Concentrations of heavy metals in mine tailings and the nearby soil exceeded the standard (agricultural area) of Soil Environment Conservation Law. So it was thought that remediation for mine tailings and the nearby soil is needed. The pollution indices of the samples in this study were for higher than 1.0 and the pollution degree was very serious. Priority remediation site for these mines was Wondong. As Results of danger indices, it was showed that exchangeable form in Wondong and Fe-Mn oxide form in the rest mines should be removed preferentially.

A Study on the Treatment of Landfill Leachate using Membrane and Evaporator (Lab Test) (분리막과 증발기를 이용한 매립지 침출수 처리에 관한 연구 (Lab test))

  • Kang, Shin-Gyung;Park, Yung-Kyu
    • Journal of Korean Society of Environmental Engineers
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    • v.22 no.12
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    • pp.2125-2134
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    • 2000
  • This research was to develope the economical treatment processes of the landfill leachate to meet the legal discharge standards. To achieve this purpose, experiments were conducted in laboratory to choose the optimum process and to obtain the design factors before a pi!ot-scale test. The concept of the process developing in this research was using the reverse osmosis system. The submerged membrane bio-reactor was used to achieve pre-treatment of reverse osmosis system and the concentrate was treated by evaporator with land fill gas as a fuel. The results of the research showed that SS, $BOD_5$, $COD_{cr}$, $NH_4{^+}-N$ and T-N were removed 99.0%, 43.0%, 12.9%, 48.5% and 18.7% respectively in the submerged membrane bio-reactor. The reverse osmosis system could remove $BOD_5$, $COD_{cr}$, $NH_4{^+}-N$ and T-N as an efficiency of97.5%, 97.6%, 79.7% and 85.4% respectively. The evaporator could remove $COD_{cr}$, $NH_4{^+}-N$ and T-N as an efficiency of 90.5%, 50.6% and 63.3% respectively. However the condensed water of the evaporator was not satisfied the legal standard and should be treated in reverse osmosis with the pre-treated leachate.

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Insecticidal Activity of N'-phenvl-N-Methylformamidine Analogues against Two Spotted Spider Mite (Tetranychus urticae) and Design of New Potent Compounds (두 점박이 응애(Tetranychus urticae)에 대한 N'-phenyl-N-methylformamidine 유도체의 살충활성과 새로운 고활성 화합물들의 설계)

  • Lee, Jae-Whang;Choi, Won-Seok;Lee, Dong-Guk;Chung, Kun-Hoe;Ko, Young-Kwan;Kim, Tae-Joon;Sung, Nack-Do
    • The Korean Journal of Pesticide Science
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    • v.14 no.3
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    • pp.191-198
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    • 2010
  • To predict and design of new potent insecticidal compounds, the two dimensional quantitative structure-activity relationships (2D-QSARs) and molecular hologram quantitative structure-activity relationships (HQSARs) between the various physicochemical parameters as descripters of N'-phenyl-N-methylformamidine analogues (1-22) and their insecticidal activity against the two spotted spider mite (Tetranychus urticae) were discussed quantitatively. From 2D-QSAR models (1 & 3), the width ($B_2$) of $R_3$-group as sterically factor and optimal total dipole moment (TDM=2.025D) of $R_4$-group were mainly influenced to increase the activity. Therefore, the activities were depend upon the $R_3$- and $R_4$-groups. Particularly, it is predicted that the activity of newly designed potent compound (PI; $EC_{50}$=0.516 ppm) by 2D-QSAR models (3) and HQSAR model F2 was about 34.3 fold higher than that of the commercialized insecticide, Amitraz ($EC_{50}$=17.7 ppm).

Air-conditioning and Heating Time Prediction Based on Artificial Neural Network and Its Application in IoT System (냉난방 시간을 예측하는 인공신경망의 구축 및 IoT 시스템에서의 활용)

  • Kim, Jun-soo;Lee, Ju-ik;Kim, Dongho
    • Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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    • 2018.05a
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    • pp.347-350
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    • 2018
  • In order for an IoT system to automatically make the house temperature pleasant for the user, the system needs to predict the optimal start-up time of air-conditioner or heater to get to the temperature that the user has set. Predicting the optimal start-up time is important because it prevents extra fee from the unnecessary operation of the air-conditioner and heater. This paper introduces an ANN(Artificial Neural Network) and an IoT system that predicts the cooling and heating time in households using air-conditioner and heater. Many variables such as house structure, house size, and external weather condition affect the cooling and heating. Out of the many variables, measurable variables such as house temperature, house humidity, outdoor temperature, outdoor humidity, wind speed, wind direction, and wind chill was used to create training data for constructing the model. After constructing the ANN model, an IoT system that uses the model was developed. The IoT system comprises of a main system powered by Raspberry Pi 3 and a mobile application powered by Android. The mobile's GPS sensor and an developed feature used to predict user's return.

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The Protective Effect of Ginseng Saponin against High Glucose-Induced Secretion of Insulin-Like Growth Factor (IGF)-I in Primary Cultured Rabbit Proximal Tubule Cells (신장 근위세뇨관 세포에서 고포도당에 의한 IGF-I 분비 촉진작용에 있어서 인삼의 차단효과)

  • Jung, Ho-Kyoung;Lim, Suel-Ki;Park, Min-Jung;Bae, Chun-Sik;Yoon, Kyung-Chul;Han, Ho-Jae;Park, Soo-Hyun
    • Journal of Ginseng Research
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    • v.33 no.1
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    • pp.26-32
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    • 2009
  • Diabetic nephropathy is associated with the dysfunction of proximal tubule cells. Insulin-like growth factor 1(IGF-I) has also been considered to play an important role in the development of diabetic nephropathy. Ginsenosides have been used as a remedy for diabetes in Asian countries. Therefore, we examined the preventive effect of ginsenosides against high glucose-induced alteration of IGF-I secretion in the primary cultured proximal tubule cells. In present study, Ginseng saponin (GS) completely blocked high glucose-induced stimulation of IGF-I secretion in proximal tubule cells, whereas panaxatriol (PI) and panaxadiol (PD) partially suppressed. In addition, high glucose stimulated cAMP formation and protein kinase C(PKC) activity from cytosolic to membrane fraction. GS completely prevented high glucose-induced stimulation of cAMP and PKC activity while PT and PD partially did. Furthermore, high glucose-induced stimulation of IGF-I was blocked by the treatment of PKI (protein kinase A inhibitor) and bisindolylmaleimide I (protein kinase C inhibitor). In conclusion, GS prevented high glucose-induced dysfunction of proximal tubule cells.

A Study on Deflection Characteristics of Plywood for Wood Based Flooring by Veneer Composition (마루판용 합판의 단판 구성요소에 따른 변형 특성에 관한 연구)

  • Pi, Duck-Won;Kang, Seog Goo
    • Journal of the Korean Wood Science and Technology
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    • v.41 no.1
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    • pp.42-50
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    • 2013
  • Since 1990's, a plywood for flooring base has gotten customers' demand. Costs of raw material and production increased because of changed environment of industry. Tropical timber such as Red Meranti (Shorea acuminate) used for raw material of the floor has been depleting beside countries in South Eastern Asia changed species of afforestation. As a result, it gets hard to secure good quality of raw material for plywood. Moreover plywood price is increased suddenly after earthquake in Japan. Eucalyptus (Eucalyptus globulus) in china has been using for raw material as a countermeasure of changed environment of industry. In this study, possibility of using flooring consisted of Eucalyptus veneer as crossband layers was checked by deflection experiments. Flooring consisted of Red Meranti was used for comparison. Two factors which impact on deflection are a type of density gradient and density difference between Long-grain veneer and Short-grain veneer. Red Meranti samples are M type of density gradient on the other hand Eucalyptus samples are W type of density gradient. The more samples have high density difference, the more deformation was checked. A sample which has big density difference between core and cross bands layer warp more also deform. Flooring was deformed smaller than plywood and samples which have big density difference was deformed more.

Purification and Characterization of Proteins Inhibiting Phospholipase D Activity from Flounder (Paralichthys olivaceus) Brain (넙치 (Paralichthys olivaceus) 뇌로부터 phospholipase D 활성 억제 단백질의 정제 및 특성 규명)

  • SEO Jung-Soo;KIM Eun-Hi;HWAWG Eun-Young;KIM Nam Deuk;KIM Dong Sun;LEE Hyung-Ho;CHUNG Joon-Ki
    • Korean Journal of Fisheries and Aquatic Sciences
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    • v.34 no.4
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    • pp.370-377
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    • 2001
  • Flounder brain cytosol contains protein inhibitors that markedly inhibit the activity of partially purified brain membrane phospholipase D (PLD) which is dependent on phosphatidylinositol 4,5-bisphosphate ($PIP_2$) but insensitive to ADP-ribosylation factor (ARF), The PLD inhibitors have been enriched through several chromatographic steps and characterized with respect to size and mechanism of inhibition. Sequential chromatography of the brain cytosol yielded six inhibitor fractions, Two (IIA and IIB) of six inhibitor fractions showed the $PIP_2$-phosphatase activities. IIA was identified as synaptojanin, a nerve terminal protein that has known to be a member of the inositolpolyphosphate 5-phosphatase family, by immunoblot analysis. IIB showed an apparent molecular mass of 158 kDa by Superose 12 gel filtration chromatography and was immunologically distinct from synaptojanin. IIB hydrolyzed $PIP_2$, yielding only phosphatidylinositol phosphate (PIP) as product, suggesting that IIB hydrolyzes only one phosphate from either the 4- or 5-position of PI (4,5)$P_2$. These studies demonstrate that the existence of multiple $PIP_2$-phosphatases have been implicated in the negative regulation of $PIP_2$-dependent PLD activity within flounder brain.

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Effects of NaCl on the Growth and Physiological Characteristics of Crepidiastrum sonchifolium (Maxim.) Pak & Kawano (NaCl 처리가 고들빼기의 생장과 생리적 특성에 미치는 영향)

  • Lee, Kyeong Cheol;Han, Sang Kyun;Yoon, Kyeong Kyu;Lee, Hak bong;Song, Jae Mo
    • Korean Journal of Medicinal Crop Science
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    • v.28 no.1
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    • pp.1-8
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    • 2020
  • Background: This study was conducted to investigate the effects of NaCl concentration on the photosynthetic parameters, chlorophyll fluorescence and growth characteristics of Crepidiastrum sonchifolium. Methods and Results: As treatments, we subjected C. sonchifolium plants to four different concentrations of NaCl (0, 50, 100 and 200 mM). We found that the photosynthetic parameters maximum photosynthesis rate (PN max), net apparent quantum yield (Φ), maximum carboxylation rate (Vcmax), and maximum electron transport rate (Jmax) were significantly reduced at an NaCl concentration greater than 100 mM. In contrast, there was an increase in water-use efficiency with increasing NaCl concentration, although in terms of growth performances, leaf dry weight, root dry weight, stem length, and total dry weight all decreased with increasing NaCl concentration. Furthermore, leakage of electrolytes, as a consequence of cell membrane damage, clearly increased in response to an increase in NaCl concentration. Analysis of the polyphasic elevation of chlorophyll a fluorescence transients (OKJIP) revealed marked decrease in flux ratios (ΦPO, ΨO and ΦEO) and the PIabs, performance index in response to treatment with 200 mM NaCl, thereby reflectings the relatively reduced state of photosystem II. This increase in fluorescence could be due to a reduction in electron transport beyond Q-A. We thus found that the photosynthetic parameters, chlorophyll fluorescence and growth characteristics of C. sonchifolium significantly increased in response to treatment with 200 mM NaCl. Conclusions: Collectively, the findings of this study indicate that C. sonchifolium shows relatively low sensitivity to NaCl stress, although photosynthetic activity was markedly reduced in plants exposed to 200 mM NaCl.