• Title/Summary/Keyword: ${\omega}-3$

Search Result 2,908, Processing Time 0.03 seconds

Influence of $\omega$-Conotoxin GVIA, Nifedipine and Cilnidipine on Catecholamine Release in the Rat Adrenal Medulla

  • Yu, Byung-Sik;Kim, Byeong-Cheol;Lim, Dong-Yoon
    • The Korean Journal of Physiology and Pharmacology
    • /
    • v.11 no.1
    • /
    • pp.21-30
    • /
    • 2007
  • The present study was designed to establish comparatively the inhibitory effects of cilnidipine(CNP), nifedipine(NIF), and $\omega$-conotoxin GVIA(CTX) on the release of CA evoked by cholinergic stimulation and membrane depolarization from the isolated perfused model of the rat adrenal medulla. CNP(3 ${\mu}M$), NIF(3 ${\mu}M$), and CTX(3 ${\mu}M$) perfused into an adrenal vein for 60 min produced greatly inhibition in CA secretory responses evoked by ACh($5.32{\times}10^{-3}M$), DMPP($10^{-4}M$ for 2 min), McN-A-343($10^{-4}M$ for 2 min), high $K^+(5.6{\times}10^{-2}M)$, Bay-K-8644($10^{-5}M$), and cyclopiazonic acid($10^{-5}M$), respectively. For the CA release evoked by ACh and Bay-K-8644, the following rank order of potency was obtained: CNP>NIF>CTX. The rank order for the CA release evoked by McN-A-343 and cyclopiazonic acid was CNP>NIF>CTX. Also, the rank orders for high $K^+$ and for DMPP were NIF>CTX>CNP and NIF>CNP>CTX, respectively. Taken together, these results demonstrate that all voltage-dependent $Ca^{2+}$ channels(VDCCs) blockers of cilnidipine, nifedipine, and $\omega$-conotoxin GVIA inhibit greatly the CA release evoked by stimulation of cholinergic(both nicotinic and muscarinic) receptors and the membrane depolarization without affecting the basal release from the isolated perfused rat adrenal gland. It seems likely that the inhibitory effects of cilnidipine, nifedipine, and $\omega$-conotoxin GVIA are mediated by the blockade of both L- and N-type, L-type only, and N-type only VDCCs located on the rat adrenomedullary chromaffin cells, respectively, which are relevant to $Ca^{2+}$ mobilization. It is also suggested that N-type VDCCs play an important role in the rat adrenomedullary CA secretion, in addition to L-type VDCCs.

Characteristics of Large Area ITO/PET Fabricated by Vacuum Web Coater (진공 웹코터로 제작된 대면적 ITO/PET의 특성 연구)

  • Kim, Ji-Hwan;Park, Dong-Hee;Kim, Jong-Bin;Byun, Dong-Jin;Choi, Won-Kook
    • Korean Journal of Materials Research
    • /
    • v.17 no.10
    • /
    • pp.516-520
    • /
    • 2007
  • Indium tin oxide, which is used as transparent conducting layer in flexible device, is deposited on PET film by a magnetron sputtering in 300 mm wide roll-to-roll process (vacuum web coating). Sheet resistance, specific resistance and transmittance is differed by sputtering parameters such as working pressures, oxygen partial pressure, and thickness of ITO layer. ITO layer is deposited about 90 nm at roll speed of 0.24 m/min and its sputtering power is 3 kW. From the XRD spectrum deposited ITO layer is verified as amorphous. Under working pressure varied from $3{\times}10^{-4}\;Torr$ to $2{\times}10^{-3}\;Torr$, sheet resistance is lowest at the working pressure of $1{\times}10^{-3}\;Torr$ and its value is from $110\;{\Omega}/{\square}$ to $260\;{\Omega}/{\square}$ at the thickness of 90 nm. Oxygen partial pressure also varies sheet resistance and is optimized at the regime from 0.2% ($1.8{\times}10^{-6}\;Torr$) to 0.6% ($6{\times}10^{-6}\;Torr$). In this oxygen partial pressure sheet resistance is lower than $150\;{\Omega}/{\square}$. As ITO layer thickness increases, sheet resistance decreases down to $21\;{\Omega}/{\square}$ and specific resistance is about $7.5{\times}10.4{\Omega}cm$ in 340 nm thickness ITO layer. Transmittance is measured at the wavelength of 550 nm and is about 90% for 180 nm thickness ITO/PET.

Stretchable Deformation-Resistance Characteristics of Metal Thin Films for Stretchable Interconnect Applications II. Characteristics Comparison for Au, Pt, and Cu Thin Films (신축 전자패키지 배선용 금속박막의 신축변형-저항 특성 II. Au, Pt 및 Cu 박막의 특성 비교)

  • Park, Donghyun;Oh, Tae Sung
    • Journal of the Microelectronics and Packaging Society
    • /
    • v.24 no.3
    • /
    • pp.19-26
    • /
    • 2017
  • Stretchable deformation-resistance characteristics of Au, Pt, and Cu films were measured for the stretchable packaging structure where a parylene F was used as an intermediate layer between a PDMS substrate and a metal thin film. The 150 nm-thick Au and Pt films, sputtered on the parylene F-coated PDMS substrate, exhibited the initial resistances of $1.56{\Omega}$ and $5.53{\Omega}$, respectively. The resistance increase ratios at 30% tensile strain were measured as 7 and 18 for Au film and Pt film, respectively. The 150 nm-thick Cu film, sputtered on the parylene F-coated PDMS substrate, exhibited a very poor stretchability compared to Au and Pt films. Its resistance was initially $18.71{\Omega}$, rapidly increased with applying tensile deformation, and finally became open at 5% tensile strain.

Humidity Sensitive Properties of Humidity Sensor using Quaternized Cross-linked Copolymers of Vinylbenzyl chloride (4차 염화 가교화된 Vinylbenzyl chloride 공중합체를 감습막으로 이용한 습도센서의 감습 특성)

  • Lee, Seong-Su;Gong, Myeong-Seon
    • Korean Journal of Materials Research
    • /
    • v.10 no.12
    • /
    • pp.825-830
    • /
    • 2000
  • The copolymers with various composition of vinylbenzyl chloride (VBC), methyl methacrylate (MMA), and 2-hydroxyethyl methacrylate(HEMA) were synthesized as a humidity sensitive material and quaternized with N, N, N', N'-tetraethylene diamine.. Resistance versus relative humidity decreased with increase in the content of MMA in the copolymer. The introduction of HPMA increased the resistance of the humidity sensor as well as enhanced the adherence to the alumina substrate. In the case of VBC/MMA/HEMA=80/10/10, the hysteresis and temperature dependency coefficient were $\pm$2%RH and -0.46~0.42%RH/$^{\circ}C$. The average resistance at 30%RH, 60%RH and 90%RH were 3.0M$\Omega$ ,200k$\Omega$ and 9k$\Omega$, respectively.

  • PDF

Humidity Sensitive Properties of Humidity Sensor Using Reactive Copolymers (반응성 공중합체들을 이용한 습도센서의 감습 특성)

  • Kim, Jin-Seok;Bae, Jang-Sun;Gong, Myeong-Seon
    • Korean Journal of Materials Research
    • /
    • v.11 no.2
    • /
    • pp.126-131
    • /
    • 2001
  • The mutually reactive copolymers poly[(vinylbenzyl chloride)-co-(n-butyl acrylate)-co-(2-hydroxyethyl methacrylate)] and poly[(4-vinylpyridine)-co-(n-butyl acrylate)-co-(2-hydroxyethyl methacrylate)] were synthesized for the humidity sensitive material by forming simultaneous quaternization. The humidity sensor showed an average resistance of 8.6 M$\Omega$, 310 k$\Omega$ and 12 k$\Omega$ at 30%RH, 60%RH and 90%RH, respectively. The hysteresis and temperature coefficient were $\pm$3%RH and -0.37~-0.40%RH/$^{\circ}C$. The introduction of n-BA and HEMA increased the resistance of the humidity sensor however it enhanced the adherence to the alumina substrate. The response time was 54 seconds changing from 33%RH to 85%RH and the difference of resistance was +0.2%RH after soaking in water for 2 hr.

  • PDF

Study on the Facile Preparation of S-2-(${\omega}$-aminoalkylamino) ethyl Dihydrogen Phosphorothioates (티오인산이수소 S-2-(${\omega}$-아미노알킬아미노) 에틸들의 간편합성법 연구)

  • You Sun Kim;Suc Won Kim
    • Journal of the Korean Chemical Society
    • /
    • v.27 no.6
    • /
    • pp.449-456
    • /
    • 1983
  • The facile route of preparing S-2-(${\omega}$-aminoalkylamino) ethyl dihydrogen phosphorothioates, potential chemical radioprotectants, have been studied. Intermediate 3-(2-phthalimidoethyl)-2-oxazolidinone was prepared by a reaction of potassium phthalimide and 3-(2-bromoethyl)-2-oxazolidinone, which was obtained through the alkaline ring closure of a mixture of carbonate and 2,2'-dibromo diethylamine prepared from diethanolamine. This was converted to N-[2-(2-bromoethylamino)ethyl] phthalimide hydrobromide by 30% HBr(gas) in acetic acid and N-(2-bromoethyl)-1,2-ethanediamine dihydrobromide was obtained by reacting the hydrobromide with a solution of HBr-HOAc. N-(2-bromoethyl)-1,3-propanediamine dihydrobromide could be prepared through the Cortese treatment of 2-(3-aminopropylamino) ethanol, which was prepared by a reaction of 1,3-diaminopropane and 2-chloroethanol. These dihydrobromides were treated by sodium thiophosphate in DMF to result S-2-(${\omega}$-aminoalkylamino) ethyl dihydrogen phosphorothioates. The characteristics of each reaction path were discussed in regards to reaction conditions and overall yields and a facile route of preparing each derivative was proposed.

  • PDF

Characterization of a fad3 cDNA Encoding Microsomal Fatty Acid Desaturase from Arabidopsis thaliana (Arabidopsis thaliana로부터 지방산 불포화효소 유전자의 분석)

  • 박희성;임경준
    • Korean Journal of Plant Tissue Culture
    • /
    • v.24 no.2
    • /
    • pp.93-97
    • /
    • 1997
  • For the molecular genetic study of cold tolerance mechanism in plants, a cDNA encoding fatty acid desaturase (fad3), converting linoleic acid (18:2, $\omega$-6) to linolenic acid (18:3, $\omega$-3), was isolated from $\lambda$ZAPII Arabidopsis thaliana cDNA expression library by plaque hybridization using fad3 cDNA probe derived from Brassica napus. A 1.8 kb-EcoRI fragment from a lambda clone showing a strong positive hybridization signal was subcloned into pGEM7 and analyzed for its nucleotide sequence. From deduced amino acid sequences, the fad3 gene was revealed to have an open reading frame(ORF) consisting of 386 amino acids with a molecular mass of 44,075 Da. The fad3 gene was compared to chloroplast $\omega$-3 fatty acid desaturase (fad7) and endoplasmic reticulum Δ12 fatty acid desaturase (fad2) to show 70% and 58% amino acid sequence homology, respectively, Especially, amino acids of internal (82 to 151) and carboxy terminal (276 to 333) regions were highly conserved, implying their requisite role for enzymatic functioning of fatty acid desaturases. IPTG-induced fad3 cDNA expression in E. coli cells was suggested to be toxic to bacterial growth.

  • PDF

Synthesis and Characterization of ${\omega}-Sulfonated$ Polystyrene-stabilized Cadmium Sulfide Nanoclusters

  • Jin Yong Hyun;Kim Jungahn;Im Seung Soon
    • Macromolecular Research
    • /
    • v.12 no.6
    • /
    • pp.604-607
    • /
    • 2004
  • We report an important and useful method for preparing ${\omega}-sulfonated$ polystyrene-stabilized cadmium sulfide (CdS) nanoclusters. The ${\omega}-sulfonated$ polystyrene $(M_n\;=\;5000\;g/mol)$ was prepared successfully through chain-end sulfonation of poly(styryl)lithium using 1,3-propanesultone; the resulting polymer was used successfully as a polymeric stabilizing agent for the preparation of semiconductor CdS nanoclusters by reduction of cadmium acetate in a mixture of toluene and methanol (9:1, v/v). The nanoclusters that formed were characterized by a combination of transmission electron microscopy, X-ray diffraction, and UVN is spectroscopic analysis. The ${\omega}-sulfonated$ polystyrene-stabilized CdS nanoclusters synthesized in this study exhibited the cubic phase (zinc-blende phase) structure in the range of 2-8 nm.

THE TENSOR PRODUCTS OF SPHERICAL NON-COMMUTATIVE TORI WITH CUNTZ ALGEBRAS

  • Park, Chun-Gil;Boo, Deok-Hoon
    • Journal of the Chungcheong Mathematical Society
    • /
    • v.10 no.1
    • /
    • pp.127-139
    • /
    • 1997
  • The spherical non-commutative $\mathbb{S}_{\omega}$ were defined in [2,3]. Assume that no non-trivial matrix algebra can be factored out of the $\mathbb{S}_{\omega}$, and that the fibres are isomorphic to the tensor product of a completely irrational non-commutative torus with a matrix algebra $M_k(\mathbb{C})$. It is shown that the tensor product of the spherical non-commutative torus $\mathbb{S}_{\omega}$ with the even Cuntz algebra $\mathcal{O}_{2d}$ has a trivial bundle structure if and only if k and 2d - 1 are relatively prime, and that the tensor product of the spherical non-commutative torus $S_{\omega}$ with the generalized Cuntz algebra $\mathcal{O}_{\infty}$ has a non-trivial bundle structure when k > 1.

  • PDF

MULTIPLICITY RESULTS FOR NONLINEAR SCHRÖDINGER-POISSON SYSTEMS WITH SUBCRITICAL OR CRITICAL GROWTH

  • Guo, Shangjiang;Liu, Zhisu
    • Journal of the Korean Mathematical Society
    • /
    • v.53 no.2
    • /
    • pp.247-262
    • /
    • 2016
  • In this paper, we consider the following $Schr{\ddot{o}}dinger$-Poisson system: $$\{\begin{array}{lll}-{\Delta}u+u+{\lambda}{\phi}u={\mu}f(u)+{\mid}u{\mid}^{p-2}u,\;\text{ in }{\Omega},\\-{\Delta}{\phi}=u^2,\;\text{ in }{\Omega},\\{\phi}=u=0,\;\text{ on }{\partial}{\Omega},\end{array}$$ where ${\Omega}$ is a smooth and bounded domain in $\mathbb{R}^3$, $p{\in}(1,6]$, ${\lambda}$, ${\mu}$ are two parameters and $f:\mathbb{R}{\rightarrow}\mathbb{R}$ is a continuous function. Using some critical point theorems and truncation technique, we obtain three multiplicity results for such a problem with subcritical or critical growth.