• Molecules and Cells
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• 제19권2호
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• pp.289-293
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• 2005

BAF53 is an actin-related protein that shuttles between nucleus and cytoplasm. In the nucleus, it constitutes an integral component of many chromatin-modifying complexes such as the SWI/SNF, TIP60, TRRAP, and TIP48/49 complexes. BAF53 is essential for growth, but its function remains elusive. BAF53 homologues from yeast to humans have a conserved N-terminal motif, MS_(G/A)(G/A)__(V/L)YGG, which is unique to these proteins. Previously we showed that over-expression of an N-terminal deletion mutant of BAF53 ($BAF53_-{\Delta}N$) reduced the viability of HEK293 and HeLa cells. When we replaced the serine 2 and tyrosine 6 of this N-terminal motif with alanine, over-expression of the alanine-replaced BAF53 strongly impaired the growth of HEK293 cells whereas replacement with aspartate/glutamate had no effect. The alanine-replaced BAF53 mutants also stimulated p53-dependent transcription, in which the SWI/SNF and TRRAP complexes are involved. Our results demonstrate that serine 2 and tyrosine 6 play important roles in BAF53 activity.

• 한국축산식품학회지
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• 제29권5호
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• pp.590-598
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• 2009

The aim of this study was to model and optimize the calcium alginate (CA) and microbial transglutaminase (TG) systems to form a cold-set myofibrillar protein (MP) gel containing 0.1 M or 0.3 M NaCl using a response surface methodology. The gel strengths of cold-set and heat-induced MP gels, and cooking yields were measured. All measured parameters showed determination coefficients ($R^2$) above 0.7 without a lack-of-fit. The CA system had the best results with component ratios of 1.0:0.3:1.0 corresponding to sodium alginate, calcium carbonate and glucono-$\delta$-lactone, respectively, and was favourable at 0.1 M NaCl. In contrast, the TG system only had an effect on cold-set MP gelation at 0.3 M salt, and the optimal ratio of TG to sodium caseinate was 0.6:0.5. By combining the two systems at 0.3 M NaCl, an acceptable cold-set MP gel with an improved texture and high cooking yield could be formed. Therefore, these results indicated that the functionality of the cold-set MP gel could be enhanced by combining these two optimized gelling system.

• Journal of Electrical Engineering and Technology
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• 제13권6호
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• pp.2425-2433
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• 2018

This study investigates a new organic based material and its dielectric and mechanical properties. It is a comprehensive nanocomposite comprising a combination of various types of nanofillers with hydrophobic silica nanoparticles (AEROSIL R 974) as a matrix modifier and a polyamide nano nonwoven textile, Ultramid-Polyamide 6, pulped in the electrostatic field as a dielectric barrier. The polymer matrix is an epoxy network based on diglycidyl ether of bisphenol A (DGEBA) and cycloaliphatic diamine (Laromine C260). The designed nanocomposite material is an alternative to the conventional three-component composites containing fiberglass and mica with properties that exceed current electroinsulating systems (volume resistivity on the order of $10^{16}{\Omega}{\cdot}m$, dissipation factor tan ${\delta}=4.7{\cdot}10^{-3}$, dielectric strength 39 kV/mm).

• Wind and Structures
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• 제26권5호
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• pp.317-329
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• 2018

Wake characteristics of the flow over a finite square prism at different incidence angles were experimentally investigated using an open-loop wind tunnel. A finite square prism with a width D = 15 mm and a height H = 7D was vertically mounted on a horizontal flat plate. The Reynolds number was varied from $6.5{\times}10^3$ to $28.5{\times}10^3$ and the incidence angle ${\alpha}$ was changed from $0^{\circ}$ to $45^{\circ}$. The ratio of boundary layer thickness to the prism height was about ${\delta}/H=7%$. The time-averaged velocity, turbulence intensity and the vortex shedding frequency were obtained through a single-component hotwire probe. Power spectrum of the streamwise velocity fluctuations revealed that the tip and base vortices shed at the same frequency as that ofspanwise vortices. Furthermore, the results showed that the critical incidence angle corresponding to the maximum Strouhal number and minimum wake width occurs at ${\alpha}_{cr}=15^{\circ}$ which is equal to that reported for an infinite prism. There is a reduction in the size of the wake region along the height of the prism when moving away from the ground plane towards the free end.

• The Korean Journal of Physiology
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• 제21권1호
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• pp.67-77
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• 1987

Effect of intravenously injected clonidine on the flexion reflex was studied in 15 decerebrated and spinalized cats. The flexion reflex was elicited by electrical stimulation of the tibial nerve or the common peroneal nerve and it was recorded as single unit activity from filaments of the L6 or L7 ventral roots. In order to obtain the late flexion reflex discharges, $A{\delta}$ and C afferent fibers were stimulated with single or train electrical pulses respectively. The flexion reflex, especially the late component, was markedly inhibited after intravenous administration of clonidine. The clonidine-induced inhibition of the flexion reflex was compared before and after treatment of the animals respectively with yohimbine and naloxone. The inhibitory effect on the flexion reflex of clonidine was not altered by naloxone, a ${\mu}-opioid$ receptor blocker, whereas it was completely blocked by yohimbine, an ${\alpha}_2-adrenergic$ antagonist. These results indicate that clonidine inhibits the flexion reflex through excitation of ${\alpha}_2-adrenoceptors$ even at the spinal cord level.

• 한국결정성장학회지
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• 제23권1호
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• pp.20-26
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• 2013

Special attention in the role of convection in vapor crystal growth has been paid since some single crystals under microgravity environments less than 1 $g_0$ exhibits a diffusive-convection mode and much uniformity in front of the crystal regions than a normal gravity acceleration of 1 $g_0$. The total molar fluxes show asymmetrical patterns in interfacial distribution, which indicates the occurrence of either one single or more than one convective cell. As the gravitational level decreases form 1 $g_0$ down to $1.0{\times}10^{-4}\;g_0$, the intensity of convection, indicative of the maximum molar fluxes, is reduced significantly for ${\Delta}T=30K$ and 90 K. The total molar fluxes decay first order exponentially with the partial pressure of component B, PB (Torr) for 20 Torr ${\leq}PB{\leq}$ 300 Torr, and two gravity accelerations of $g_y=1\;g_0$ and 0.1 $g_0$.

• Structural Engineering and Mechanics
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• 제23권6호
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• pp.651-674
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• 2006

The fatigue cracks initiate and propagate in the Armored Vehicle Launch Bridge (AVLB) components, especially like the splice doubler angle, splice plate, and bottom chord, due to the cyclic loading by repeated AVLB-launchings and tank-crossings. In this study, laboratory fatigue tests were conducted on six aluminum 2014-T6, four aluminum 7050-T76511, and four ASTM A36 steel compact-tension specimens to evaluate the crack growth behavior of the materials used for the components. The experimental results provide the relationship (Paris Law) between crack growth rate, da/dn, and stress intensity range, ${\Delta}K$, whose material dependent constants C and m can later be used in the life estimation of the components. Finite Element Method (FEM) was used to obtain the stress intensity factor, K, of the components with cracks. Because of the complexity of loading conditions and component geometry, several assumptions and simplifications are made in the FEM modeling. The FEM results, along with the results obtained from laboratory fatigue tests, are then utilized to estimate critical crack length and remaining life of the components.

• 한국해양공학회지
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• 제27권1호
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• pp.37-42
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• 2013

The presence of a crack can increase the local stress or strain, which can cause inelastic deformation and significantly reduce the life of a component or structure. Therefore, in this study, the fatigue crack growth (FCG) behaviors of friction stir welded Al 2024-T3 and Al 7075-T6 specimens were examined, with fatigue cracks growing parallel to the dynamically recrystallized zone at variable ${\Delta}K$ values and an R ratio of 0.3. In addition, the FCG values of the base metal Al 2024-T3 and Al 7075-T6 were tested under the same conditions and parameters as comparative groups. The results showed that compared with the base metal Al 2024 specimen, which had the best fatigue property, the welded specimen had only 88% of the fatigue cycles.

• 전력전자학회논문지
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• 제20권1호
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• pp.19-30
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• 2015

A static synchronous compensator (STATCOM) applied to rapidly changing, highly unbalanced loads such as electric arc furnaces (EAFs), requires both positive-sequence and negative-sequence current control, which indicates fast response characteristics and can be controlled independently. Furthermore, a delta-connected STATCOM with cascaded H-bridge configuration accompanying multiple separate DC-sides, should have high performance zero-sequence current control to suppress a phase-to-phase imbalance in DC-side voltages when compensating for unbalanced load. In this paper, actual EAF data is analyzed to reflect on the design of current controllers and a pioneering zero-sequence current controller with a superb transient performance is devised, which generates an imaginary -axis component from the presumed response of forwarded reference. Via simulation and experiments, the performance of the positive, negative, and zero-sequence current control of a cascaded H-bridge STATCOM for EAF is verified.

• 대한전기학회논문지:전기물성ㆍ응용부문C
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• 제54권4호
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• pp.149-153
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• 2005

We have investigated thermal properties showed by changing the content of carbon black which is the component parts of semiconductive shield in underground power transmission cable. Specimens were made of sheet with the nine of those for measurement. Heat capacity (${\Delta}$H), glass transition temperature (Tg) and melting temperature (Tm) were measured by DSC (Differential Scanning Calorimetry). The ranges of measurement temperature were from -100($^{\circ}C$) to 100($^{\circ}C$), and heating rate was 4($^{\circ}C$/min). And then thermal diffusivity was measured by LFA 447. The dimension of measurement temperature was 25[$^{\circ}C$]. Glass transition temperature of specimens was showed near -25[$^{\circ}C$] and the heat capacity and the melting temperature from the DSC results were simultaneously decreased according to increasing the content of carbon black, while thermal diffusivity was increased according to increasing the content of carbon black. Because ionic impurities of carbon black having Fe, Co, Mn, Al and Zn are rapidly passed kinetic energy increasing the number of times breaking during the unit time with the near particles according to increasing vibration of particles by the applied heat energy.