• Title/Summary/Keyword: ${\beta}-sitosterol{\

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Potentially Hepatoprotective Glycolipid Constituents of Lycium chinense Fruits

  • Jung Kiwon;Chin Young-Won;Kim Young Choong;Kim Jinwoong
    • Archives of Pharmacal Research
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    • v.28 no.12
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    • pp.1381-1385
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    • 2005
  • Further investigation of Lycium chinense fruits gave a mixture of (6'-O-palmitoyl)- and (6'-O­stearoyl)-$\beta$-sitosterol-3-O-$\beta$-D-glucopyranoside (1) and two glycolipids, 1-O-(9Z, 12Z, 15Z-octa­decatrienoyl)-2-O-(9Z, 12Z, 15Z-octadecatrienoyl)-3-O-$\beta$-D-galactopyranosyl glycerol (2) and 1-O-(9Z, 12Z-octadecadienoyl)-2-O-(9Z, 12Z, 15Z-octadecatrienoyl)-3-O-$\beta$-D-galactopyranosyl glycerol (3). These compounds were newly isolated as constituents of L. chinense.

Evaluation of Estrogenic Activity of Pumpkin Seed Extract using Recombinant Yeast Assay (재조합 효모를 이용한 호박씨 추출물의 에스트로겐 활성 평가)

  • Tahk, Hong-Min;Lee, Bog-Hieu;Rho, Sook-Nyung;Kim, Chun-Soo;Jung, Ji-Youn;Choi, Chang-Sun
    • Journal of Food Hygiene and Safety
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    • v.24 no.2
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    • pp.124-127
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    • 2009
  • The aim of this study is to evaluate the estrogenic activity of Cucurbita pepo seed extract which includes ${\beta}-sitosterol$ and other phytosterols. Sample was extracted from Cucurbita pepo seed by supercritical carbondioxide method and resuspended with ethanol. Estrogenic activity was measured by recombinant yeast assay which detects estrogenic activity using recombinant yeast with high level of estrogenic receptor. However, estrogenic activity of pumpkin seed extract was not found in this study. Based on this data, pumpkin seed extract will not cause estrogenic disturbance.

Isolation of Melanin Biosynthesis Inhibitory Compounds from the Seeds of Plantago asiatica L. (차전자(車前子)로부터 멜라닌 생성 억제물질의 분리)

  • Oh, Joon-Seok;Lee, Jong-Gu;Jung, Hee-Wook;Choi, Ji-Young;Choi, Eun-Hyang;Kim, Dong-Chun;Kim, Jeong-Ah;Son, Jong-Keun;Lee, Seung-Ho
    • Korean Journal of Pharmacognosy
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    • v.38 no.4
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    • pp.376-381
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    • 2007
  • Seven compounds were isolated from the MeOH extract of the seeds of Plantago asiatica L. and their structures were identified as ${\beta}-sitosterol$ (1), (24R)-6${\beta}$-hydroxy-24-ethyl-cholest-4-en-3-one (2), acteoside (3), geniposidic acid (4), 1-octen-3-ol 3-O-${\beta}$-D-xylopyranosyl$(1{\rightarrow}6)-{\beta}-D-glucopyranoside$ (5), plantainoside D (6) and plantamajoside (7) on the spectroscopic analysis. Among them, $(24R)-6{\beta}$-hydroxy-24-ethyl-cholest-4-en-3-one (2) and 1-octen-3-ol 3-O-${\beta}$-D-xylopyranosyl ($1{\rightarrow}6)-{\beta}-D-glucopyranoside$ (5) were first isolated from this plant. Among them, geniposidic acid (4) showed the most potent inhibitory effect on melanogenesis, with inhibition rate of 41%.

Research on the Quality Properties of Olive Oils Available in Korea (국내 유통되는 올리브오일의 품질특성 실태조사)

  • Kim, Hyeon-Wee;Bae, Soo-Kyung;Yi, Hai-Soon
    • Korean Journal of Food Science and Technology
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    • v.35 no.6
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    • pp.1064-1071
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    • 2003
  • An investigation of various olive oils available in Korea was carried out to assess their quality properties such as color, oxidative stability, fatty acid composition, tocopherol content, sterol content and benzo(a)pyrene content. In color measurement, by using a Lovibond color scale and Hunter color difference meter, both a and b values of extra virgin olive oil were higher than those of pure olive oil by Tintometer (Lovibond PFX995). However, extra virgin olive oil showed higher a value and lower L value than pure olive oil by the Hunter color difference meter. In the rancimat test, the induction period of extra virgin olive oil $(38.03{\sim}8.47hr)$ was longer than that of pure olive oil $(32.40{\sim}9.94hr)$. In fatty acid composition, C18:1 $(72.01{\sim}78.53wt%)$ was present in the greatest amount, with lesser amounts of C18:2 $(4.88{\sim}10.36wt%)$ and C18:3 $(0.56{\sim}1.09wt%)$. The tocopherol content ranged from ${\alpha}-Toc\;4.09{\sim}13.89mg/100g$, ${\beta}-Toc\;0.57{\sim}1.34mg/100g$, and ${\gamma}-Toc$ $3.41{\sim}8.03mg/100g$, and ${\alpha}-tocopherol$ was found to be the main isomer in all oil samples. Therefore, there was little difference in the fatty acid composition and tocopherol content among the different types of olive oils. In sterol content, ${\beta}-sitosterol$ $(124.52{\sim}19.33mg/100g)$ and campesterol $(1.10{\sim}0.62mg/100g)$ of extra virgin olive oil were higher than that of pure olive oil $({\beta}-sitosterol\;92.68{\sim}17.44mg/100g,\;campesterol\;0.59{\sim}0.35mg/100g)$. Benzo(a)pyrene was found in almost all samples, with $0.287{\sim}0.106{\mu}g/kg$ in extra virgin olive oil and $1.204{\sim}2.130{\mu}g/kg$ in pure olive oil.

Chemical Constituents of Korean Chopi (Zanthoxylum piperitum) and Sancho (Zanthoxylum schinifolium) (한국산 초피와 산초의 화학성분)

  • Ko, Young-Su;Han, Hee-Ja
    • Korean Journal of Food Science and Technology
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    • v.28 no.1
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    • pp.19-27
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    • 1996
  • Zanthoxylum piperitum and Z. schinifolium have been utilized not only as food stuffs, but also as medicinal plants in Korea. In this study, lipids, sugar, amino acids and other components of Zanthoxylum piperitum and Z. schinifolium peels and seeds were analyzed by HPLC and GLC. Four samples contained common fatty acids such as linoleic, linolenic, palmitic, oleic and stearic acid. The contents of unsaturated fatty acids were 87.1% and 64.8% in Z. schinifolium peels and seeds, 73.6% and 62.9% in Z. piperitum peels and seeds, respectively. Z. schinifolium peels contained only beta-sitosterol, whereas other three samples contained campesterol, stigmasterol and beta-sitosterol. In case of free amino acids, peels of both species showed higher contents of acids than seeds of both species. Glutamic acid, aspartic acid, arginine, valine, and leucine were found in all four samples. Essential oils consisted of limonene (30.1-66.8%), beta-phellandrene (4.8-13.3%), citronellal (1.5-22%) and cineol (1.6-3.9%). It is worthwhile to note that the content of citronellal in Z. schinifolium seeds was higher than that of the others.

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Triterpenoids from Orostachys japonicus

  • Lee, Sang-Hyun;Paek, Sun-Ha;Kim, Seung-Ki;Kim, Bak-Kwang;Shin, Kuk-Hyun
    • Natural Product Sciences
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    • v.10 no.6
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    • pp.306-309
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    • 2004
  • Triterpenoids were isolated from the whole plant of Orostachys japonicus (Crassulaceae) by repeated column chromatography. Their structures were identified as friedelin (1), glutinol (2), ${\beta}-sitosterol$ (3), friedelinol (4), $5{\alpha},8{\alpha}-peroxyergosterol$ (5), ${\beta}-sitostenone$ (6) and glutinone (7) by spectral analysis. Among them, compounds 5 and 6 were isolated for the first time from this plant.

Phytochemical Constituents of Bitter Melon (Momordica charantia)

  • Kim, Hyun Young;Mok, So-Youn;Kwon, Su Hyeong;Lee, Dong Gu;Cho, Eun Ju;Lee, Sanghyun
    • Natural Product Sciences
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    • v.19 no.4
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    • pp.286-289
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    • 2013
  • Phytochemical constituents were isolated from bitter melon (the fruits of Momordica charantia) through open column chromatography. Their structures were identified as ${\beta}$-sitosterol (1), (23E)-$5{\beta}$,19-epoxycucurbita-6,23-diene-$3{\beta}$,25-diol (2), daucosterol (3), uracil (4), and allantoin (5) by interpretation of spectroscopic analysis including MS and $^1H$- & $^{13}C$-NMR. Among them, allantoin (5) was isolated from this plant for the first time.

Sterols and Sterol Glycosides from Cuscuta Reflexa

  • Anis, E.;Mustafa, G.;Ahmed, S.;Nisarullah, Nisarullah;Malik, A.;Afza, N.;Badar, Y.
    • Natural Product Sciences
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    • v.5 no.3
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    • pp.124-126
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    • 1999
  • A new natural product $stigmast-5-en-3-O-{\beta}-D-glucopyranoside$ tetraacetate (1) along with known compounds $stigmast-5-en-3-O-{\beta}-D-glucopyranoside$ (2), stigmast-5-en-3-yl-cetate (3) and ${\beta}-sitosterol$ (4) have been isolated from the stems of Cuscuta reflexa. Their structures were elucidated on the basis of chemical and spectroscopic evidence.

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Structure Elucidation of Analgesic Constituents from Yerba Buena Leaves

  • Canlas, Arlyn P.
    • Proceedings of the Korean Society of Applied Pharmacology
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    • 1998.11a
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    • pp.169-169
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    • 1998
  • Three analgesic constituents: FB2c, FB6Fc, and FB10E5c from the hexane extract of Mentha cordifolia Opiz. (Yerba buena) leaves were isolated by solvent partitioning and sequential repeated vacuum liquid chromatography. Spectral analysis of the three constituents show that FB2c is ${\beta}$-sitosterol; FB10E5c is ${\beta}$-sitosteryl-${\beta}$-D-glucopyranoside; and FB6Fc is a cis-8- pentadecenyl with lactone variety. At a dosage of 100 mg/kg mouse, isolates FB2c, FB6Fc, and FB10E5c decreased the number of squirms induces by acetic acid by 70.0 %, 67.3 %, and 73.0 %, respectively.

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Cytotoxic Constituents of Rhododendron brachycarpum (만병초의 세포독성 성분)

  • Jang Gi Uk;Choi Sang Un;Lee Kang Ro
    • YAKHAK HOEJI
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    • v.49 no.3
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    • pp.244-248
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    • 2005
  • From the methanol extract of Rhododendron brachycarpum four triterpenes, three phenylpropanes and a diterpene alkaloid were isolated. Their structures were identified as glutinol (1), 3$\beta$-hydroxyurs-12-ene (2), $\beta$-sitosterol (3), (E)-P-hydrox-ycinnamic acid hexadecylester (4), (-)-rhododendrol (5), (+)-rhododendrol (6), 3$\beta$-hydroxyurs-12-en-28-oic acid (7) and gray-anotoxin I (8) by spectroscopic methods. Compound 8 showed moderate cytotoxicity against five cultured human tumor cell lines with $ED_{50}$ values of $3.21\~4.05 {\mu}g/ml$. The other compounds were of marginal activity against the tested cell lines.