• 대한화학회지
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• 제38권2호
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• pp.169-173
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• 1994

인도네시아 Manado만의 Sulawesi에서 채집한 미동정된 해면으로부터 KB cancer cell line에 대해 활성을 갖는 xestoquinone, halenaquinol sulfate 및 halenaquinol이 검출되었다. 이들을 $^1H-,\;^{13}C$-NMR, $^1H-,\;^{13}C$(1 bond) heteronuclear Multiple Quantum Cogerence Spectroscopy$(HMQC)^1$, $^1H-,\;^{13}C$C(2 and 3 bond) Heteronuclear multiple Bond Correlation Spectroscopy$(HMBC)^2$, Electron Impact Mass Spectroscopy(EI ms), UV 및 IR에 의해 밝혔다.

• 한국잠사곤충학회지
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• 제17권2호
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• pp.161-170
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• 1975

This study is to investigate the content of crude protein intruded in the sericin of cocoon shell and pupa by treatment of buffer solution (pH 1 to pH 13) 20 ml per 1 gram for 30 and 60 minutes at 30$^{\circ}C$, 60$^{\circ}C$ and 100${\pm}$2$^{\circ}C$, respectively. The results obtained are summarized as follows. 1. The quantity of total crude protein obtained from cocoon shell and pupa by treatment during 30 minutes at 30$^{\circ}C$ was dissolved as the largest quantity of 11.874 mg/g at pH 1 and l5.93mg/g at pH 13, but dissolved the smallest quantity 1.75g/g at pH 5 as known. and tile quantity of crude protein treated for 60 minutes is 13.437mg/g at pH 1 and 22.50mg/g at pH 13. Also, the smallest quantity is 2. 813mg/g at pH 5 as known. 2. By the treatment during 30 minutes at 60$^{\circ}C$, the dissolved largest quantity was 13.12mg/g at pH 1 and 21.875 mg/g at pH 13, but the smallest quantity is 2.375mg/g at pH 5 as known After treatment for 60 minutes at 60$^{\circ}C$, the dissolved largest quantity was 17.500 mg/g at pH 1 and 31.56mg/g at pH 13, bu the smallest quantity is 3.849 mg/g at pH 5. 3. The dissolved crude protein from the cocoon shell and pupa by treatment for 30 minutes at 100${\pm}$2$^{\circ}C$ was the largest quantity of 147.000mg/g at pH 1 and 398. 125mg/g at pH 13, but the smallest quantity is 75.00mg/g at pH 5 as known. After treatment for 60 minutes at 100${\pm}$2$^{\circ}C$, the largest quantity was 253.76 mg/g at pH 1 and 460.625mg/g at pH 13, but the smallest quantity is 139.375mg/g at pH 5 as known. 4. The dissolved crude protein from the cocoon shell and pupa was not different in quantity by treatment at 30$^{\circ}C$ or 60$^{\circ}C$. But dissolved crude protein was large quantity from cocoon shell more than pupa, as known. 5. The treatment of cocoon shell and pupa during 60 minutes at 100${\pm}$20$^{\circ}C$ was increased to the dissolved largest quantity of crude protein of 19.20％ at pH 1 and 22. 18％ at pH 13 from the cocoon shell and 6. 12％ at pH, an d 23.87％ at pH 13 from the pupa. But dissolved crude protein was increased to the larger quantity from pupa more than cocoon shell.

• 대한화학회지
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• 제39권4호
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• pp.301-305
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• 1995

인도네시아 Manado만의 Sulawesi에서 채집한 해면 Spongia sp.로부터 KB Cancer cell line에 대하여 활성을 갖는 halenaquinone, epispongiatriol 및 aldisin을 분리하였다. 이들의 구조를 $1^H,\;13^C\;NMR\;1^H\;13^C(1\;bond)$ Heteronuclear Multiple Quantum Coherence Spectroscopy (HMQC), 1H 13C(2 and 3 bond) Heteronuclear Multiple Bond Correlation Spectroscopy (HMBC), Electron Impact Mass Spectroscopy (EI ms) 및 IR로 밝혔다.

• 대한화학회지
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• 제17권3호
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• pp.169-173
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• 1973

세자리 schiff base리간드로서 salicylidene amino-o-hydroxy benzene 은 salicylaldehyde와 o-amino phenol로서 합성하였으며 이 세자리 schiff base 리간드와 Mo(VI), Mo(V), Mo(IV) 및 Mo(III) 의 과산화상태의 몰리브덴 착물들의 반응으로 새로운 착물[Mo O$_2(H_2O)\;(C_{13}H_9O_2N)]$, [MoO Cl(H$_2O)(C_13H_9O_2N)]$, $[Mo(SCN)_2(H_2O)(C_{13}H_9O2_N)]$ 및 $[Mo(H_2O)_2 (C_{13}H_9O_2N)]_2O$들을 얻었다. 이들 착물에서 Mo(VI), Mo(V) 및 Mo(IV)착물들은 리간드와 몰리브덴의 mole비가 1:1인 착물로서 몰리브덴 이온은 6배위 팔면체로서 주어지나 Mo(III) 착물은 Mo-O-Mo의 산소 bridge bond를 갖는 poly nuclear 착물로서 mole비 1:1인 착물로 주어짐을 원소분석치와 자외선흡광도 및 적외선 spectra의 고찰로서 알아보았다.

• 한국어병학회지
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• 제24권1호
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• pp.29-37
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• 2011

Nalidixic acid(NA), piromidic acid(PA)를 사육수온 ($13{\pm}1.5^{\circ}C$, $23{\pm}1.5^{\circ}C$)에 따라서 조피볼락(평균체중 $500{\pm}30\;g$)에 60 mg/kg의 농도로 1회 경구투여한 다음, 시간경과에 따라 혈청 내 잔류농도를 분석하였다. $23{\pm}1.5^{\circ}C$의 경우, 투여 후 NA는 24시간째($5.87\;{\mu}g/ml$), PA도 24시간째($0.43\;{\mu}g/ml$)에 각각 최대혈중농도에 도달하였다. $13{\pm}1.5^{\circ}C$의 경우, 투여 후 NA는 10시간 째($6.22\;{\mu}g/ml$), PA도 10시간째($1.57\;{\mu}g/ml$)에 각각 최대혈중농도에 도달하였다. PA의 조피볼락 혈중 내 흡수정도는 $23{\pm}1.5^{\circ}C$보다 $13{\pm}1.5^{\circ}C$에서 매우 높게 나타났으며, NA는 수온에 따른 차이가 크지 않았다. NA 및 PA의 조피볼락 혈중 내 소실정도는 $13{\pm}1.5^{\circ}C$ 보다 $23{\pm}1.5^{\circ}C$에서 두드러지게 빨랐다. NA 및 PA는 one-compartment model로 해석(WinNonlin program)하여 약물동태학적 변수(parameter)를 조사하였다. $23{\pm}1.5^{\circ}C$의 경우, 혈장농도-시간곡선하 면적(AUC)은 NA, PA가 각각 161.25 및 $41.57\;{\mu}g{\cdot}h/ml$, 반감기($T_{1/2}$)는 0.15 h 및 0.58 h, 혈중최고농도의 도달 시간($T_{max}$)은 12.29 및 8.24 h, 혈중최고농도($C_{max}$)는 3.85 및 $0.21\;{\mu}g/ml$로 계산되었다. $13{\pm}1.5^{\circ}C$의 경우, AUC는 NA, PA가 각각 134.42 및 $40.36\;{\mu}g{\cdot}h/ml$, $T_{1/2}$은 0.18 h 및 0.59 h, $T_{max}$는 10.67 및 21.15 h, $C_{max}$는 8.91 및 $3.09\;{\mu}g/ml$로 계산되었다.

• 한국어병학회지
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• 제23권2호
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• pp.221-227
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• 2010

Oxolinic acid를 사육수온($13{\pm}1.5^{\circ}C$, $23{\pm}1.5^{\circ}C$)에 따라서 조피볼락(평균체중 500 g)에 60 mg/kg의 농도로 1회 경구 투여한 다음, 경시적인 혈청내 잔류농도를 분석하였다. $23{\pm}1.5^{\circ}C$의 경우 투여 후 30시간째($0.60{\mu}g/ml$)에 최대혈중농도에 도달하였다. $13{\pm}1.5^{\circ}C$의 경우 투여 후 10시간째($2.22{\mu}g/ml$) 최대혈중농도에 도달하였다. OA의 조피볼락 혈중내 흡수양상과 소실정도는 사육수온에 크게 영향을 받았다. Two-compartment model로 해석하여 WinNonlin program을 이용, 약물동태학적 매개변수(parameter)를 조사하였다. $23{\pm}1.5^{\circ}C$의 경우, 혈장농도－시간곡선하 면적(AUC)은 $42.16{\mu}g{\cdot}h/ml$, 혈중최고농도의 도달시간(Tmax)은 26.13 h, 혈중최고농도(Cmax)는 $0.43{\mu}g/ml$, 예상약물소실시간(Et)은 230시간으로 계산되었다. $13{\pm}1.5^{\circ}C$의 경우, AUC는 $131.98{\mu}g{\cdot}h/ml$, Tmax는 8.81 h, Cmax는 $2.04{\mu}g/ml$, Et는 492시간으로 계산되었다.

• Journal of Ginseng Research
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• 제19권1호
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• pp.45-50
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• 1995

(20S)- and (20R)-protopanaxadiol were prepared from crude ginseng saponin by chemical treatment. The $^{1}H$- and $^{13}C$-NMR signals of these compounds were fully assigned by various NMR techniques such as DEPT, 1H-1H COSY, HMQC, HMBC and NOESY.

• Asian-Australasian Journal of Animal Sciences
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• 제20권10호
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• pp.1517-1524
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• 2007

The [$^2H_5$]phenylalanine model was compared with the [1-$^{13}C$]leucine method to determine whole body protein synthesis (WBPS) and degradation (WBPD) in sheep fed at two levels. The animals were fed either 103 (M-diet) or 151 (H-diet) kcal $ME/kg^{0.75}/day$ once daily in a crossover design for 21 days each. The isotope dilutions were simultaneously conducted as a primed-continuous infusion of [$^2H_5$]phenylalanine, [$^2H_2$]tyrosine and [1-$^{13}C$]leucine on each dietary treatment. The WBPS and WBPD calculated from the [$^2H_5$]phenylalanine model were lower (p = 0.009 and p = 0.003, respectively) than those calculated from the [1-$^{13}C$]leucine method. The WBPS tended to be higher (p = 0.08) and WBPD was numerically higher (p = 0.33) for H-diet than M-diet in the [$^2H_5$]phenylalanine model, whereas the WBPS was numerically higher (p = 0.37) for H-diet and WBPS remained similar (p = 0.79) between diets in the [1-$^{13}C$]leucine method. However, the absolute values and the directions of WBPS as well as WBPD from M-diet to H-diet were comparable between the [$^2H_5$]phenylalanine model and [1-$^{13}C$]leucine method. Moreover, the values vary depending on the use of the respective amino acid contents in the carcass protein when calculating WBPS and WBPD. Therefore, it is concluded that the [$^2H_5$]phenylalanine model could be used as an alternative to the [1-$^{13}C$]leucine method for the determination of WBPS and WBPD in sheep.

• 대한화학회지
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• 제38권10호
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• pp.749-752
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• 1994

하와이 Pohnpei에서 채집한 soft coral Sinularia lochmodes로부터 2개의 furanosesquiterpenes인 (5'E)-5-(2',6'-dimethylocta-5',7'-dienyl) furan-3-carboxylic acid (1)와 (1'E,5'E)-5-(2',6'-dimethylocta-l',5',7'-trienyl) furan-3-carboxylic acid (2)가 검출되었다. 이들의 구조를 $^1H$ , $^{13}C$ NMR, Homo-COSY, $^1H$-$^{13}C$ (1 bond) Heteronuclear Multiple Quantum Coherence Spectroscopy (HMQC), $^1H$-$^{13}C$ (2 and 3 bond) Heteronuclear Multiple Bond Coherence Spectroscopy (HMBC), Electron Impact Mass Spectroscopy (EI-ms) 및 Infrared Spectroscopy (IR)에 의해 밝혔다.

• 약학회지
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• 제40권3호
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• pp.293-299
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• 1996

The $^1H$- and $^{13}C$-NMR signals of (20R)-panaxadiol and (20R)-panaxatriol were completely assigned by the extensive application of modern 2D-NMR techniques, $^1H-^1H$ COSY, HMQC and HMBC.