• Bulletin of the Korean Chemical Society
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• v.31 no.8
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• pp.2345-2350
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• 2010

A series of thiadiazole derivatives were synthesized with differently substituted benzoic acids which were cyclized to give differently substituted thiazolidin-4-one. Elemental analysis, IR, $^1H$ NMR, $^{13}C$ NMR and mass spectral data confirmed the structure of the newly synthesized compounds. The derivatives of these moieties were evaluated for antimicrobial activity. Most of the synthesized compounds showed good antimicrobial activity at 200 and $100\;{\mu}g/mL$. Compounds showed most significant antibacterial activity against gram negative test organism Escherichia coli and most significant antifungal activity against test organisms Aspergillus niger and Candida albicans. It was observed that compounds with $OCH_3$ at 3, 4 position of phenyl ring [5(a-l)] were more potent against microbes as compared to compounds having unsubstituted phenyl ring [4(a-l)].

• Natural Product Sciences
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• v.3 no.1
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• pp.42-48
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• 1997

The roots of Tabernaemontana macrocarpa Jack (Apocynaceae) yielded nine indole alkaloids which were identified as coronaridine (2), voacangine hydroxy-indolenine (3), 3-oxo-coronaridine (4), 19-R-heyneanine (7), coronaridine pseudoindoxyl (8) and voacangine pseudoindoxyl (9) while 3-(2-oxopropyl)-coronaridine (1), 3-(2-oxopropyl)-coronaridine-pseudoindoxyl (5) and 3-(2-oxopropyl)-voacangine-pseudoindoxyl (6) were isolated as artefacts formed during the isolation process. All of the alkaloids were identified by spectroscopic methods $(UV,\;MS,\;^1H-NMR\;&\;^{13}C-NMR)$ and in comparison with the literature data.

• Natural Product Sciences
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• v.24 no.1
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• pp.54-58
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• 2018

A phytochemical investigation of Allium macrostemon Bunge (Liliaceae) afforded the new pregnane steroidal glycoside, named allimacroside F (1), along with three known glycosides, benzyl-O-${\alpha}-{\text\tiny{L}}$-rhamnopyranosyl-($1{\rightarrow}6$)-${\beta}-{\text\tiny{D}}$-glucopyranoside (2), phenylethyl-O-${\alpha}-{\text\tiny{L}}$-rhamnopyranosyl-($1{\rightarrow}6$)-${\beta}-{\text\tiny{D}}$-glucopyranoside (3), (Z)-3-hexenyl-O-${\alpha}-{\text\tiny{L}}$-rhamnopyranosyl-($1{\rightarrow}6$)-${\beta}-{\text\tiny{D}}$-glucopyranoside (4). The identification and structural elucidation of a new compound (1) was carried out based on spectral data analyses ($^1H-NMR$, $^{13}C-NMR$, $^1H-^1H$ COSY, HSQC, HMBC, and NOESY) and HR-FAB-MS.

• Bulletin of the Korean Chemical Society
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• v.31 no.11
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• pp.3180-3182
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• 2010

A simple facile 'one pot' synthesis of 2-amino-3-cyano-4,6-diarylpyridine derivatives via three component reaction of chalcone, malanonitrile and ammonium acetate under ultrasonic irradiation and grindstone technology. All the synthesized compounds have been characterized on the basis of their elemental analyses and spectral data (IR, $^1H$ NMR, $^{13}C$ NMR and Mass).

• Bulletin of the Korean Chemical Society
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• v.35 no.2
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• pp.551-556
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• 2014

The treatment of alkylated nitro derivatives of indazole with 2-(4-chlorophenyl)acetonitrile under basic conditions gave the new 8-chloro-3-alkyl-3H-pyrazolo[4,3-a]acridine-11-carbonitriles via the nucleophilic substitution of hydrogen which proceeds at room temperature with concomitant cyclisation in fairly good yields. The structures of all newly synthesized compounds were confirmed by IR, $^1H$ NMR, $^{13}C$ NMR and mass spectral data. Fluorescence experimental results of all newly synthesized compounds revealed remarkable photoluminescence properties and strong green fluorescence properties. Also, the new compounds exhibited potent antibacterial activity and their antibacterial activity (MIC) against Gram positive (Staphylococcuse aureus methicillin resistant S. aureus and Bacillus subtilis) and negative bacterial (Pseudomonas aeruginosa and Escherichia coli) species were determined.

• Journal of the Korean Society of Tobacco Science
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• v.25 no.1
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• pp.80-86
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• 2003

The contents of valepotriates, valerenic acid and their derivatives as mild sedative and antispamodic principles in two Korean valerian roots (Valeriana officinalis var. latifolia Miq. and V. fauriei var. dasycarpa Hara) were investigated and were compared with those in European valerian roots(Valeriana officinalis L.) by BPLC method. Among valepotriate compounds, valtrate was detected as a small amount in two Korean valerian roots, and iso-valtrate and dihydrovaltrate were detected as a trace amount. Among valerenic acid and their derivatives, valerenic acid were contained from 0.9∼3.46 mg/g base on dry weight. Over the vegetation periods investigated, the content of valepotriates remained more or less constant, hut the content of valerenic acid reached its maximum in 3-year old age. The compound isolated from Korean V. officinalis var. latifolia was elucidated as valerenic acid by spectroscopic data such as GC-MS, $^1$H-NMR and $^{13}$ C-NMR, and comparison of GC retention time with that of authentic compound.

• Journal of Applied Biological Chemistry
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• v.42 no.4
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• pp.197-201
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• 1999

Antagonistic bacteria active against phytopathogenic fungi, Phytophthora capsici, Pythium ultimum, Rhizoctonia solani, Botrytis cinerea, and Fusarium oxysporum were isolated from greenhouse soils. An antifungal compound was extracted by ethyl acetate from acidified culture filtrate and purified through column chromatography and thin layer chromatography. Activity-guided bioassay was followed throughout the purification steps using Pythium ultimum as a test organism. The purified antifungal compound was identified as phenylacetic acid (PAA) based on the data obtained from IR, EI/MS, $^1H-NMR$, and $^{13}C-NMR$. Two different isolates, which had vast differences in differential characteristics except 16S rDNA sequence homology, produced the same compound, phenylacetic acid. $ED_{50}$ values of the phenylacetic acid against P. ultimum, P. capsici, R. solani, B. cinerea, and F. oxysporum were 45, 21, 318, 360, and 226 ppm, respectively.

• Bulletin of the Korean Chemical Society
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• v.32 no.3
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• pp.1011-1016
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• 2011

A series of thiadiazole derivatives were synthesized with differently substituted benzoic acids which were cyclized to give differently substituted thiazolidin-4-one. Elemental analysis, IR, $^1H$ NMR, $^{13}C$ NMR and mass spectral data confirmed the structure of the synthesized compounds. The derivatives of these moieties were evaluated for anticonvulsant activity by MES model and neurotoxicity by rotarod method. The synthesized compounds showed good potential for anticonvulsant activity besides this, the compounds also showed neurotoxic effect. It was observed that compounds with $OCH_3$ at 3, 4 position of phenyl ring [5(a-l)] showed less protection against convulsions as compared to compounds having unsubstituted phenyl ring [4(a-l)].

• Bulletin of the Korean Chemical Society
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• v.30 no.8
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• pp.1715-1718
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• 2009

A series of sitting-atop (SAT) complexes, [(ZrO)$H_2t(X)pp(NO_3)_2$], have been prepared via the reactions of free base meso-tetraarylporphyrins, $H_2$t(X)pp, with zirconyl nitrate hydrate, ZrO(N$O_3)_2{\cdot}xH_2$O. The products have been characterized by a variety of methods including $^1H\;NMR,\;^{13}C$ NMR, IR and UV-Vis spectroscopies, elemental analysis and conductance measurements. The data indicate that the meso-tetraarylporphyrins coordinate with two pyrrolenine nitrogen atoms to the zirconyl cation located above the distorted porphyrin plane and two protons remain on the pyrrole nitrogens. Such half sandwich-type sitting-atop complexes may be considered as models for the initial steps of the metallation of the macrocycles.

• Journal of the Korean Chemical Society
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• v.55 no.6
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• pp.969-973
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• 2011

The synthesis, as well as spectroscopic and biological studies of a novel class of [3-(4-substitutedphenylamino)-8-azabicyclo [3.2.1] oct-8yl]-phenyl-methanone derivatives are described. All the synthesized compounds were characterized by elemental analysis FTIR, $^1H$-NMR, $^{13}C$ NMR, and Mass spectral data. All the synthesized compounds were exhibit in vitro antibacterial activity.