Alkaloids from The Roots of Tabernaemontana Macrocarpa Jack

  • Husain, Khairana (Department of Chemistry, University Kebangsaan Malaysia) ;
  • Said, Ikram M. (Department of Chemistry, University Kebangsaan Malaysia) ;
  • Din, Laily B. (Department of Chemistry, University Kebangsaan Malaysia) ;
  • Takayama, Hiromitsu (Faculty of Pharmaceutical Sciences, Chiba University) ;
  • Kitajima, Mariko (Faculty of Pharmaceutical Sciences, Chiba University) ;
  • Aimi, Norio (Faculty of Pharmaceutical Sciences, Chiba University)
  • Published : 1997.06.01

Abstract

The roots of Tabernaemontana macrocarpa Jack (Apocynaceae) yielded nine indole alkaloids which were identified as coronaridine (2), voacangine hydroxy-indolenine (3), 3-oxo-coronaridine (4), 19-R-heyneanine (7), coronaridine pseudoindoxyl (8) and voacangine pseudoindoxyl (9) while 3-(2-oxopropyl)-coronaridine (1), 3-(2-oxopropyl)-coronaridine-pseudoindoxyl (5) and 3-(2-oxopropyl)-voacangine-pseudoindoxyl (6) were isolated as artefacts formed during the isolation process. All of the alkaloids were identified by spectroscopic methods $(UV,\;MS,\;^1H-NMR\;&\;^{13}C-NMR)$ and in comparison with the literature data.

Keywords