• 수산해양기술연구
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• 제48권1호
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• pp.82-90
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• 2012

Four different buildings having various wall construction are analyzed for the effect of wall mass on the thermal performance and inside building air and wall temperature transient and also for calculating the energy consumption load. This analytical study was motivated by the experimental work of Burch et al. An analytical solution of one-dimensional, linear, partial differential equations is obtained using the Laplace transform method, Bromwich and modified Bromwich contour method. A simple dynamic model using steady state analysis as simplified methods is developed and results of energy consumption loads are compared with results obtained using the analytical solution. Typical Meteorological Year data are processed to yield hourly average monthly values. This study is conducted using weather data from two different locations in Korea: Daegu having severe weather in summer and winter and Jeju having mild weather almost all year round. There is a significant wall mass effect on the thermal performance of a building in mild weather condition. Buildings of heavyweight construction with insulation show the highest comfort level in mild weather condition. A proportional controller provides the higher comfort level in comparison with buildings using on-off controller. The steady state analysis gives an accurate estimate of energy load for all types of construction. Finally, it appears that both mass and wall insulation are important factors in the thermal performance of buildings, but their relative merits should be decided in each building by a strict analysis of the building layout, weather conditions and site condition.

• 대한화학회지
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• 제56권2호
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• pp.236-245
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• 2012

The main mycobacterial infection in human is tuberculosis caused by Mycobacterium tuberculosis. Tuberculosis is the leading infectious cause of death in the world. Therefore there is continuing and compelling need for new and improved treatment for tuberculosis. The entire logic towards design of new compounds containing 4-hydroxy-N'-(1,3-thiazoldin- 2-yldene)benzohydrazide moiety is basically for superior antimycobacterial activity. The recent advances in QSAR and computer science have provided a systematic approach to design a structure of any compound and further, the biological activity of the compound can be predicted before synthesis. The 3D-QSAR studies for the set of 4-hydroxy-N'-(1,3-thiazoldin- 2-yldene)benzohydrazide and their derivatives were carried out by using V-life MDS (3.50). The various statistical methods such as Multiple Linear Regression (MLR), Partial Least Square Regression (PLSR), Principle Component Regression(PCR) and K nearest neighbour (kNN) were used. The kNN showed good results having cross validated $r^2$ 0.9319, $r^2$ for external test set 0.8561 and standard error of estimate 0.2195. The docking studies were carried out by using Schrodinger GLIDE module which resulted in good docking score in comparison with the standard isoniazid. The designed compounds were further subjected for synthesis and biological evaluation. Antitubercular evaluation of these compounds showed that (4.a), (4.d) and (4.g) found as potent inhibitor of H37RV.

• 한국수자원학회논문집
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• 제42권8호
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• pp.631-641
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• 2009

본 연구는 부영양화되어 있는 하구감조역에서의 $N_2O$생성과 거동을 파악하는 것을 목적으로 도시역에서의 N2O발생에 착안하여 그 중에서도 인위적 임팩트가 크다고 판단되는 하수처리수 생활폐수 등이 유입되는 도시하천감조역을 대상으로 현지 정점조사를 실시하여 수역의 사계절에 걸친 각 질소성분의 농도변화와 flux를 상세히 파악하고 저질간극수 중의 연직분포를 측정하였다. 그 결과, 완혼합이고 염수쐐기설(楔)가 형성되는 Tatara천(川)에서 하수처리수는 해수의 혼합형태의 영향을 크게 받고 고농도수괴(水塊)로서 표층을 이동하고 있으며, 이 수역의 질소변환기구 및 $N_2O$생성과정에 큰 영향을 미치고 있는 것이 밝혀졌다. 이 수역에서 관측된 $N_2O$농도는 1.8-20.9 $\mu M$로서 대기중의 포화농도와 담수중의 포화농도를 고려하면 항상 포화농도상태이며, 주발생원은 수역저토였다. 저질간극수 중의 각 질소성분의 농도분포는 호소와 인근해역에서의 분포와는 달리 분자확산 이외의 수송경로가 있다는 것이 시사되었다.

• 대한후두음성언어의학회지
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• 제20권2호
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• pp.136-140
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• 2009

Background and Objectives: Recurrent respiratory papillomatosis (RRP) is difficult to treat because of its tendency to recur and spread throughout the aerodigestive tract. We aimed to estimate the effect of intralesional injections of cidofovir in patients with RRP. Materials and Method: Within the period from January 2003 to July 2007, 13 patients aged 2 to 61 years were treated with intralesional injections of cidofovir combined with surgical excision of RRP. Cidofovir was injected intralesionaly at a concentration of 5 mg/cc after complete removal of the papilloma with $CO_2$ laser or microdebrider. We evaluated the effect of intralesional cidofovir therapy by comparing pre-treatment mean interval of recurrence with post-treatment interval of recurrence. Results: Of 13 patients, two patients showed complete response during follow up period and four patients showed partial response. Seven patients did not respond to cidofovir at all. Mean pre-treatment mean interval of recurrence was 9 months and mean post-treatment interval of recurrence was 13.1 months (p=0.039). There was a statistical significance between the injected dose of cidofovir and post-treatment interval of recurrence (p=0.009). There were no local or systemic side effects caused by cidofovir. Conculsion : Intralesional injection of cidofovir seems to have a potential of a safe and effective adjuvant therapy of RRP. There was a positive correlation between the injected dose of cidofovir and patient clinical outcomes so that administration of higher doses and more frequency of injections should be needed to reduce recurrence. Further study regarding injection therapy regimen for RRP is required.

• 한국근적외분광분석학회:학술대회논문집
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• 한국근적외분광분석학회 2001년도 NIR-2001
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• pp.1622-1622
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• 2001

The purpose of this research was to develop a the reflection technique with near infrared (NIR) radiation for estimating physico-chemical properties in compost. The composts (cattle, pig, chicken and waste composts) were air dried and then ground to pass through a 0.5 or 2mm sieve for the physico-chemical properties and spectroscopic determinations. The physico-chemical properties of compost were shown high values ; moisture(30-60%), T-N(0.8-2.9%), organic matter(29-89%), pH(5.89-9.60) K$_2$O(0.27-5.66%), P2O$\sub$5/(0.07-2.62%), CaO(0.03-4.80%), MgO(0.09-1.56%), NaCl(0.01-1.13%), EC(1.41-13.76dS/m). Generally, we should select a simple calibration and prediction method for determining physico-chemical properties in compost under similar accuracy and precision of prediction. It should be remembered that the NIRS approach will never replace the traditional methods. However, NIRS technique may be an effective method for rapid and nondestructive measurements of a large number of compost samples. Near infrared reflectance spectra of composts was obtained by Infra Alyzer 500 scanning spectrophotometer at 2-nm intervals from 1100 to 2500nm. Multiple linear regression(MLR) or partial least square regression (PLSR) was used to evaluate a NIRS method for the rapid and nondestructive determination of physico-chemical properties and humic acid contents in composts. The standard error of prediction(SEP) for finely sized sample(<0.5mm) and coarsely sized sample(<2mm) did not show much difference. The NIR instrument of filter type showed the same accuracy of the monochromator scanning type to estimate the compost properties. The results summarized that NIR spectroscopy can be used as a routine testing method to determine quantitatively the OM, moisture, T-N, color, pH, cation content in the compost samples nondestructively.

• Journal of Biosystems Engineering
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• 제27권3호
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• pp.259-266
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• 2002

It is crucial to know spatial soil variability for precision farming. However, it is time-consuming, and difficult to measure spatial soil properties. Therefore, there are needs fur sensing technology to estimate spatial soil variability, and for electronic mapping technology to store, manipulate and process the sampled data. This research was conducted to develop a real-time soil organic matter sensor and an electronic mapping system. A soil organic matter sensor was developed with a spectrophotometer in the 900∼1,700 nm range. It was designed in a penetrator type to measure reflectance of soil at 15cm depth. The signal was calibrated with organic matter content (OMC) of the soil which was sampled in the field. The OMC was measured by the Walkeley-Black method. The soil OMCs were ranged from 0.07 to 7.96%. Statistical partial least square and principle component regression analyses were used as calibration methods. Coefficient of determination, standard error prediction and bias were 0.85 0.72 and -0.13, respectively. The electronic mapping system was consisted of the soil OMC sensor, a DGPS, a database and a makeshift vehicle. An algorithm was developed to acquire data on sampling position and its OMC and to store the data in the database. Fifty samples in fields were taken to make an N-fertilizer dosage map. Mean absolute error of these data was 0.59. The Kring method was used to interpolate data between sampling nodes. The interpolated data was used to make a soil OMC map. Also an N-fertilizer dosage map was drawn using the soil OMC map. The N-fertilizer dosage was determined by the fertilizing equation recommended by National Institute of Agricultural Science and Technology in Korea. Use of the N-fertilizer dosage map would increase precision fertilization up to 91% compared with conventional fertilization. Therefore, the developed electronic mapping system was feasible to not only precision determination of N-fertilizer dosage, but also reduction of environmental pollution.

• 한국우주과학회:학술대회논문집(한국우주과학회보)
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• 한국우주과학회 2008년도 한국우주과학회보 제17권2호
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• pp.34.4-35
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• 2008

The significant I&T process gain represented by reduction in overall budget expenditure can be obtained from the use of efficient alignment technique for large space optical systems. Such process gain tends to increase rapidly with an increase in aperture and/or in number of optical elements within the system. However, in practice, the alignment of multiple optical components tends to be rather difficult task because of the multiple coupling effects among the elements within the target system. In order to understand and hence identify the complex interplay of the wavefront coupling effects from the alignment process, the original differential wavefront sampling(DWS) method was presented elsewhere in recent years. DWS uses partial differential of the wavefront of optical component and perturbation value of the optical component against a particular alignment factor. The straightforward application of DWS for an off-axis optical system revealed that it tends to give incorrect estimation of the given misalignment state. In this study, we added off-axis correction terms to the original DWS algorithm and investigated its alignment performance. The performance simulation result for a Korsch type space optical system shows that the modified DWS is capable of bringing the misaligned system into the target alignment tolerance only after 3 iterations. It also shows that this new improved algorithm can be used to estimate the source misalignment as well. We are planning to apply this method for the alignment of a 800mm Korsch type telescope in the near future. We discuss the computational technique, simulation results and implications in details.

• 한국산학기술학회논문지
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• 제10권10호
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• pp.2609-2614
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• 2009

휴대용 초음파 탐지기(Ultrasonic Detector)는 전기설비에서 발생하는 부분방전, 코로나, 아킹, 트래킹 등과 같은 전기적 방전현상 탐지에 매유 유용하다. 그러나 초음파 탐지기는 측정음의 특성을 사용자가 듣고 판정함으로써 주관적 반응에 의해 그 결과가 좌우되거나 정확히 판정하기 곤란하게 된다. 따라서 초음파 음의 특성을 구별할 수 있는 새로운 분석적 방법이 요구된다. 본 연구에서는 초음파 탐지기에 의해 측정된 코로나, 아킹, 트래킹의 초음파 음을 시각화 할 수 있는 초음파 분석프로그램을 개발하였다. 개발된 프로그램에 의한 분석적 방법을 사용함으로써 초음파 음의 특성에 의존하던 기존의 방식보다 초음파 진단결과의 정확성을 높일 수 있게 된다.

• 대한한의학회지
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• 제37권3호
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• pp.47-61
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• 2016

Objectives: The objective of this research is to develop new animal-experimental model for Sasang Constitutional Medicine, especially for partial Taeyangin(one of four constitution which has good pulmonary function and poor hepatic function) by AAP intraperitoneal injection, and to estimate from the viewpoint of obesity and lipid metabolism. Methods: The C57bl/6J mice was divided into 4 groups ; Normal group, AAP group, High-Fat-Diet(HFD) group, and HFD+AAP group. 200mg AAP was injected intraperitoneally to the AAP group twice a week for six weeks, and HFD group was fed with 60%-High-fat Diet for six weeks. HFD+AAP group got both AAP injection and 60%-High-fat Diet at the same time for the same period. In this period, We measured the weight and Food Efficiency Ratio(FER, %) once a week. After six weeks, We conducted the blood chemical test from the groups, and extracted the fat tissue to measure weight. Results & conclusion: In the liver function test, two AAP groups had higher AST and ALP, and normal LDH. The blood level of creatinine from all groups were normal. The rate in weight was lesser by 7.8% in HFD+AAP group, and had lesser FER than HFD group. Also They had lesser Total cholesterol and LDL cholesterol, and had more HDL cholesterol than HFD group. HFD+AAP group hadmore glucose in serum and lesser Insulin-like Growth Factor 1(IGF-1) than HFD group.

• 한국콘텐츠학회:학술대회논문집
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• 한국콘텐츠학회 2007년도 추계 종합학술대회 논문집
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• pp.146-150
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• 2007

인터넷이 생활의 일부가 되어가면서 정보의 양도 급속도로 늘어나고 있으며, 이로 인해 많은 데이터 속에서 정보를 찾아내는 기술이 부각되고 있다. 협력적 필터링은 유사한 선호도를 기반으로 관심을 가질 것으로 생각되는 아이템을 추천하는 방법이다. 그러나 비슷한 선호도를 가진 일부 사용자의 정보를 바탕으로 하기 때문에 나머지 사용자의 정보를 무시하는 경향이 있다. 본 논문에서는 여학생의 선호도를 이용한 감성공학적 의상 코디를 제안한다. 이는 유전자 알고리즘에 의한 적합함수로 평가값을 계산하고 a-cut을 이용하여 사용자를 군집한다. 마지막으로 협력적 필터링에 의해 의상 코디를 추천한다. 성능평가를 위해 설문조사 데이터 집합에서 FAIMS-I, FAIMS-II과 비교 평가하였다.