• Title/Summary/Keyword: $\beta$-carboline

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$\beta$-carboline alkaloids of polygala tenuifolia

  • Han, Byung-Hoon;Park, Jeong-Hill;Park, Myung-Hwan;Han, Yong-Nam
    • Archives of Pharmacal Research
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    • v.8 no.4
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    • pp.243-247
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    • 1985
  • A new $\beta$-carboline alkaloid, 1-carbobutoxy-$\beta$-carboline as well as $N_{9}$ -formylharman, 1-carboethoxy-$\beta$-carboline, 1-carbomethoxy-$\beta$- carboline, perloyrine, harman and norharman were isolated from the rhizoma of Polygala tenuifolia Willdenow. The structures were elucidated on the basis of spectroscopic studies and chemical evidence.

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The Synergistic Antibacterial Activity of 1-Acetyl-$\beta$-Carboline and $\beta$-Lactams Against Methicillin-Resistant Staphylococcus aureus (MRSA)

  • Shin, Hee-Jae;Lee, Hyi-Seung;Lee, Dae-Sung
    • Journal of Microbiology and Biotechnology
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    • v.20 no.3
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    • pp.501-505
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    • 2010
  • 1-Acetyl-$\beta$-carboline was isolated as an anti-MRSA agent from the fermentation broth of a marine actinomycete isolated from marine sediment. The producing strain was identified to be Streptomyces sp. by phylogenetic analysis of the 16S rRNA gene sequence. The anti-MRSA agent was isolated by bioactivity-guided fractionation of the culture extract by solvent partitioning, ODS open flash chromatography, and purification with a reversed-phase HPLC. Its structure was elucidated by extensive 2D NMR and mass spectral analyses. Combination of 1-acetyl-$\beta$-carboline with ampicillin exhibited synergistic antibacterial activity against MRSA.

Alkaloidal Components of panax ginseng

  • Han, Byung-Hoon;Park, Myung-Hwan;Han, Yong-Nam;Woo, Lin-Keun
    • Archives of Pharmacal Research
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    • v.9 no.1
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    • pp.21-23
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    • 1986
  • Over twelve alkaloids were delected in the roots of Panax ginseng C. A. Meyor. Among them three alkaloids were isolated and were identified as $N_{9}$-formylharman, ethyl $\beta$-carboline-1-carboxylate and perlolyrine on the basis of spectroscopic studies.

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Anticariogenic $\beta$-Carboline Alkaloids from Commelina communis

  • Bae, Ki-Hwan;Seo, Won-Jun;Kwon, Yae-ho;Baek, Soo-Hyun;Lee, Shin-Woong;Jin, Kap-duck
    • Archives of Pharmacal Research
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    • v.15 no.3
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    • pp.220-223
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    • 1992
  • The methanolic extract of Commelina communis (aerial part) showed antibacterial activity against a cariogenic bacterium, Streptococcus mutans OMZ 176. The active principles were identified to be $\beta$-carboline alkaloids, 1-carbomethoxy-$\beta$-carboline, norharman and harman, which were bactericidal in the minimal inhibitory concentration (MIC) of $100\;\mu{g/ml}$ against the strain.

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Analysis of alkaloids in Polygala tenuifolia by HPLC (HPLC에 의한 원지 중 알칼로이드 성분의 정량)

  • Park, Man Ki;Park, Jeong Hill;Kim, Bao-Yuan;Kim, Jong Moon;Liem, Kyung-Jin;Han, Byung Hoon
    • Analytical Science and Technology
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    • v.6 no.3
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    • pp.255-259
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    • 1993
  • ${\beta}$-Carboline alkaloids of Polygala tenuifolia (Polygalaceae), an expectorant, tonic and sedative drude drug, were determined by HPLC. The alkaloids were separated by RP-18 column with gradient elution of 0.01M potassium phosphate buffer(pH=3.5) and acetonitrile and detected at UV 254nm. Two methods for the preparation of alkaloid fraction were compared. One was solvent extraction method using acid and base, and the other was solid phase extraction with ion exchange resin (Amberlyst 15). A more refined HPLC chromatogram was obtained using the solid phase extraction method. The alkaloidal contents in P. tenuifolia determined by this method were : harman $2.8{\times}10^{-3}%$, norharman $1.7{\times}10^{-3}%$, 1-carbomethoxy-${\beta}$-carboline $1.3{\times}10^{-3}%$, 1-carboethoxy-${\beta}$-carboline $1.4{\times}10^{-3}%$ and perlolyrine $3.3{\times}10^{-3}%$, respectively.

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Studies on the Alkaloidal Constituents of Commelina communis (닭의장풀의 알카로이드 성분에 관한 연구(I))

  • Baek, Soo-Hyun;Seo, Won-Jun;Bae, Ki-Hwan;Jin, Kap-Duck
    • YAKHAK HOEJI
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    • v.34 no.1
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    • pp.34-39
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    • 1990
  • The alkaloidal constituents of Commelina communis(Commelinaceae) were investigated. From the ether soluble alkaloidal fraction, three ${\beta}-carboline$ type alkaloids were isolated by chromatographic purification process. Their chemical structures were identified as $1-carbomethoxy-{\beta}-carboline$, norharman and harman from the physicochemical data, which were newly isolated from this plant.

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A Thiazole and Two ${\beta}$-Carboline Constituents from Panax ginseng

  • Park, Jong-Dae;Kim, Man-Wook;Yoo, Seung-Jo;Wee, Jae-Joon
    • Archives of Pharmacal Research
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    • v.11 no.1
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    • pp.52-55
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    • 1988
  • From the ether soluble alkaloidal fraction of Panax ginseng, 4-methyl-5-thiazoleethanol, norharman and barman were isolated. 4-Methyl-5-thiazoleethanol was isolated for the first time from natural resources.

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Studies on the Alkaloidal Components of the Fruits of Lycium chinense

  • Han, Byung-Hoon;Park, Jeong-Hill;Park, Myung-Hwan;Han, Yong-Nam
    • Archives of Pharmacal Research
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    • v.8 no.4
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    • pp.249-252
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    • 1985
  • $N_{9}$-Formylharman, 1-carbomethoxy-$\beta$-carboline and perlolyrine with an unidentified alkaloid ($C_{10}H_{13}NO_{2}$, $M^{+}$ 179.094) have been isolated from the fruits of Lycium chinense Miller (Solanaceae) and characterized on the basis of chemical and physical evidence.

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Inducible Nitric Oxide Synthase Inhibitor form Mela azedarach var. Japonica

  • Kwon, Hak-Cheol;Lee, Byeong-Gon;Kim, Seung-Hee;Jung, Chil-Mann;Hong, Sung-Youl;Han, Jeung-Whan;Lee, Hyang-Woo;Zee, Ok-Pyo;Lee, Kang-Ro
    • Archives of Pharmacal Research
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    • v.22 no.4
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    • pp.410-413
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    • 1999
  • In bioassay-guided search for inducible nitric oxide synthase (iNOS) inhibitory compounds from higher plants of South Korea, two $\beta$-carboline (2) have been isolated form the cortex of Melia azedarach var. japonica. The structures of these compounds were elucidated on the basis of spectroscopic data. Compounds 1 to 2 showed marked inhibitory activity of iNOS on LPS-and interferon-${\gamma}$-stimulated RAW 264.7 cells.

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