Archives of Pharmacal Research

The Pharmaceutical Society of Korea (대한약학회)
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Anticariogenic $\beta$-Carboline Alkaloids from Commelina communis

  • Bae, Ki-Hwan (College of Pharmacy, Chungnam National University) ;
  • Seo, Won-Jun (College of Pharmacy, Chungnam National University) ;
  • Kwon, Yae-ho (Graduate School of Environmental Studies, Yeungnam University) ;
  • Baek, Soo-Hyun (College of Pharmacy, Yeungnam University) ;
  • Lee, Shin-Woong (College of Pharmacy, Yeungnam University) ;
  • Jin, Kap-duck (College of Pharmacy, Yeungnam University)
  • Published : 1992.09.01
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Abstract

The methanolic extract of Commelina communis (aerial part) showed antibacterial activity against a cariogenic bacterium, Streptococcus mutans OMZ 176. The active principles were identified to be $\beta$-carboline alkaloids, 1-carbomethoxy-$\beta$-carboline, norharman and harman, which were bactericidal in the minimal inhibitory concentration (MIC) of $100\;\mu{g/ml}$ against the strain.

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