• Title/Summary/Keyword: $({\ll}^*,{\in})$-skeleton

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Induction of Quinone Reductase Activity by Stilbene Analogs in Mouse Hepa 1c1c7 Cells

  • Heo, Yoen-Hoi;Kim, Sang-hee;Park, Jae-Eun;Jeong, Lak-Shin;Lee, Sang-Kook
    • Archives of Pharmacal Research
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    • v.24 no.6
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    • pp.597-600
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    • 2001
  • Based on the potential cancer chemoprebentive activity of resveratrol, a trihydroxystilbene with the induction of quinone reductase activeity this study was designed to determine if stilbene-related compounds were inducers of phase ll detoxifying metabolic enzyme quinone reductase (QR) in the mouse hepatoma Hepa 1c1c7 cells. Among the thirteen compounds tested, several compounds including 3,4,5,3',5'-pentamethoxy-trans-stibene were found to potentially induce QR activity in this cell line. In addition, substitution with 3-thiofurane ring instead of phenyl ring in the stilbene skeleton also exhibited potential induction of QR activity. This result will give primary information to design the potential inducers of QR activity in the stilbene analogs.

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A Design and Implementation of Garbage Recycling Game based on Kinect Sensor (Kinect Sensor 기반의 쓰레기 분리수거 게임 설계 및 구현)

  • Won Joo Lee;An Jeong Hyun;Park Min Je;Jung Sung Hoon;Lee Jun ll
    • Proceedings of the Korean Society of Computer Information Conference
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    • 2024.01a
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    • pp.231-232
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    • 2024
  • 본 논문에서는 키넥트 센서 기반의 쓰레기 분리수거 게임을 설계하고 구현한다. 이 애플리케이션은 키넥트 센서의 스켈레톤 인식 기능을 통해 사용자를 게임 속 분리 수거통으로 표현하게 하여 분리 수거 대상 품목에 해당하는 개체에 닿으면 점수를 증가시킨다. 만일 일반 쓰레기에 닿을 시 3회의 기회가 카운트 되어 전부 소진히게 되면 게임이 종료되도록 구현한다. 해당 게임을 시행함으로써 분리수거에 적극적인 참여를 도모하여 이에 따른 행동을 취함으로 쓰레기 문제에 대한 인식을 높이고, 분리수거에 대한 재미와 도전을 제공한다.

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The Study of CYFRA 21-1 and Epidermal Growth Factor Receptor Levels in Cancer Tissue of Bronchogenic Carcinoma Patients (폐암환자의 암조직내 CYFRA 21-1과 Epidermal Growth Factor Receptor의 측정치에 대한 연구)

  • 김대연;김송명
    • Journal of Chest Surgery
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    • v.30 no.9
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    • pp.854-861
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    • 1997
  • CYPRA 21-1 is known to be a cytokeratin 19 fragment, and it can be detected by using two specific monoclonal antibodies (KS 19-1 and BM 19-21) and can be clinically applied as a useful circulating tumor marker The epidermal growth factor receptor (EGF-R) expression was evaluated and characterized by its tyrosine protein kinase activity and by its ligand-stimulated autophosphorylation, a property shared with other peptide growth factor receptors. Autocrine or para'urine action was initiated by a growth factor, or by a transforming growth factor o, which had an extensive homology with EGP and which also stimulated tyrosine kinase activity on the EGF-R. The CYFRA 21-1 and the EGF-R levels in 30 patients with primary lung tumors were investigated. There were 24 patients with squamous cell carcinomas and 6 patients with adenocarcinomas. Specimen 5 mm3 in size were sampled at three different locations ; the main lesion, the boundary between the lesion and the unaffected tissue, and the unaffected tissue of the patients. The results were as follows 1. The CYPRA 21-1 concentration in the cancer boundary, the most malignant region,(348.6 : 89.9 ng/ml) was the lowest value. The CYFRA 21-1 concentration in unaffected tissue,(718.4$\pm$77.8 ng/ml) was higher than that in the main lesion. which had intact cellularity. 2. The EGF-R concentration in the main lesion was higher than that in the unaffected tissue, and the EGF-R concentration in a squamous cell cacinoma was higher than that in an adenocarcinoma. also, the EGF-R concentration in the cancer b undary was highest at stage 1, ll. The EGF-R concentration was higher in the main cancer lesion that in the unaffected tissue at stage 111, IV. 3. The CYFRA 21-1 was a cytoplasmic skeleton and the EGF-R was a cell-wall component; there was no correlation. In conclusion, CYFRA 21-1 was abundant in the cytoplasm but had a higher concentration in the unaffected tissue than in the main cancer lesion. The CYFRA 21-1 concentration of the tissue did not reflect the amount of cancer activity, the EGP-R was located in the cell membrane, the level of tissue that reflects cancer activity, so the main cancer lesion had a higher concentration than the unaffected tissue. CYFRA 21-1 is not a useful tumor maker at the tissue level. Because the EGF-R concentration re(looted the cancer activity, its a useful tumor marker for lung cancer.

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