Archives of Pharmacal Research

The Pharmaceutical Society of Korea (대한약학회)
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Induction of Quinone Reductase Activity by Stilbene Analogs in Mouse Hepa 1c1c7 Cells

  • Heo, Yoen-Hoi (College of Pharmacy, Ewha Womans University) ;
  • Kim, Sang-hee (Natural Products Research Institute Seoul National University) ;
  • Park, Jae-Eun (Natural Products Research Institute Seoul National University) ;
  • Jeong, Lak-Shin (College of Pharmacy, Ewha Womans University) ;
  • Lee, Sang-Kook (College of Pharmacy, Ewha Womans University)
  • Published : 2001.12.01
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Abstract

Based on the potential cancer chemoprebentive activity of resveratrol, a trihydroxystilbene with the induction of quinone reductase activeity this study was designed to determine if stilbene-related compounds were inducers of phase ll detoxifying metabolic enzyme quinone reductase (QR) in the mouse hepatoma Hepa 1c1c7 cells. Among the thirteen compounds tested, several compounds including 3,4,5,3',5'-pentamethoxy-trans-stibene were found to potentially induce QR activity in this cell line. In addition, substitution with 3-thiofurane ring instead of phenyl ring in the stilbene skeleton also exhibited potential induction of QR activity. This result will give primary information to design the potential inducers of QR activity in the stilbene analogs.

Keywords

References

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