• Journal of Pharmaceutical Investigation
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• v.38 no.3
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• pp.163-169
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• 2008

Liposomes are spherical vesicles composed of lipid bilayer membranes. However, the conventional liposomes have been found to be plagued by rapid opsonization and taken up by the reticuloendothelial system (RES), resulting in shortened circulation time and limited intracellular uptake to target cell. In this study, polyethyleneglycol-cationic liposomes (PCL) containing cationic lipid and DSPE-mPEG were prepared by thin film cast-hydration method. The PEG liposomes had approximately $97.0{\pm}1.3\;nm$ of mean particle diameter and $-21.7{\pm}1.2\;mV$ of zeta potential value. PCL had $96.4{\pm}1.8\;nm$ of mean particle diameter and $-8.7{\pm}1.1\;mV$ of zeta potential value with a decrease of about 10 mV compared to the PEG liposomes. Loading of model drug, doxorubicin (DOX), in liposomes were carried out by using remote loading method and the loading efficiency of DOX in liposomes was about $95.0{\pm}1.9%$. Intracellular uptake and cytotoxicity of PCL were higher than that of PEG liposomes to murine B16F10 melanoma cells. In addition, anti-tumor activity of PCL was similar to that of PEG liposomes on growth of A549 human lung carcinoma in BALB/c mice. Consequently, PCL modified with cationic lipid may be applicable as anticancer drug carriers that can increase intracellular uptake and therapeutic efficacy.

• Journal of Life Science
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• v.12 no.2
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• pp.144-150
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• 2002

This experiment was designed to investigate the antioxidant effects of Chrysanthemum coronarium L. (CC) fractions on the liposomal phospholipid membranes. The sample CC was extracted and fractionated into five different types, methanol (CCMM), hexane (CCMH), ethylacetate (CCMEA), butanol (CCMB), and aqueous (CCMA) fractions. The antioxidant activities of CC fractions in oxidized dilinoleoylphosphatidylcholine (DLPC) liposomes were examined by spectrophotometry measuring conjugated dienes. The oxidation indices of five CC fractions exhibited weaker antioxidant activities than that of BHT in oxidized DLPC liposomes, however, showing much similar antioxidant activities of $\alpha$-tocopherol in the oxidized DLPC liposomes, which is known as a potent antioxidant. Among CC fractions, CCMM and CCMA in oxidized DLPC liposomes showed rather effective than $\alpha$-tocopherol after 2 h. These results strongly indicate that bioactive substances in CC fractions have a kind of function as potent antioxidants against biomembrane oxidation.

• Journal of the Korean Geophysical Society
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• v.3 no.2
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• pp.91-98
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• 2000

The seismicity of the Korean Peninsula shows a very irregular pattern of strain release typical of the intraplate seismicity. The Korean Peninsula may be divided into several tectonic provinces of differing tectonics. In this analysis, seismicity parameters for each tectonic province are evaluated from historical as well as instrumental earthquake data of the Korean Peninsula to examine the differences in seismic characteristics among tectonic provinces. Statistical analysis of the earthquake data made of incomplete data before the Choseon Dynasty and complete data afterwards reveals that there exist no significant differences in seismic characteristics between the tectonic provinces. It turns out the b-value in the intensity-frequency relation for the whole peninsula is about 0.6 and the maximum earthquake is about MMI X. The results of this study may be used in the probabilistic seismic hazard analysis of the Korean Peninsula and in estimating the design earthquake in earthquake engineering.

• Journal of the Korean Geophysical Society
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• v.8 no.4
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• pp.187-194
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• 2005

As a study of Arctic marine survey project, Side-scan sonar survey was carried out in the Pechora Sea belonging to the southeaster part of Barents Sea. The study area is a shallow sea 11 m-16 m deep with recent sediments of rich organic carbon. Side-scan sonar profiles show large-scale marine plant communities 2-3 m wide covering the southeastern area. A lot of lineaments are traced on the seafloor in the central and northern area. The major trends of the lineaments are 220°and 290°(WSW-ENE and WNW-ESE). This trends is thought to be a main path of icebergs. Pockmarks on the seafloor are locally distributed in the area, which are formed by fluid and/or gas discharge. These would be related with petroleum/gas system well developed around the study area. Dut to weak appearances and limited distribution of the pockmarks, more detailed studies are necessary to examine their nature and structure.

• Journal of Korean Tunnelling and Underground Space Association
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• v.20 no.4
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• pp.687-699
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• 2018

The construction of subsea tunnel differs from that of inland tunnel because of high water pressure due to sea water level and difficulties to reinforce the ground under construction. Therefore, it is very important to prevent trouble in advance when the subsea tunnel is constructed. In this paper, we established lots of databases about characteristics of geological and mechanical parameters on the construction of subsea tunnel using micro slurry TBM which depth is about 60 m. The correlation analysis is conducted to confirm the effect of thrust, torque and RPM among the excavation database on the net penetration rate. Also, An empirical formula is suggested to predict the net penetration rate through the correlation analysis between FPI (Field Penetration Index) and specific energy from the subsea tunnel excavation database.

• Korean Journal of Remote Sensing
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• v.17 no.1
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• pp.99-109
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• 2001

In order to establish effective fishing ground environment equipment and artificial reef in coastal area, the methodology to select the most suitable area for artificial reef should be applied after analyzing the correlation between fishing ground environment and ocean environment. In this paper, thematic maps were prepared by using satellite remote sensing and GIS for the sea surface temperature, chlorophyll, transparency, the depth of sea water and the condition of submarine geologic which are considered as the most elements when selecting suitable area for artificial reef in Tong-Yong bay. Then, the most suitable area for artificial reef was selected by giving weight score depending on the suitable condition of this area and analyzing spatial data. The results showed it makes possible for this methodology, which selects the suitable area for artificial reef using satellite remote sensing and GIS, to manage the institution of artificial reef more entirely and efficiently through analyzing and visualizing.

• The Journal of Engineering Geology
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• v.31 no.4
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• pp.621-630
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• 2021

This study evaluated cracks and climate monitoring in Ipseok-dae columnar joints and Jigong Neodeol rock blocks in Mudeungsan National Park. The rocks' state of cracking and their surface temperatures were measured alongside air temperature, relative humidity, and wind velocity. The maximum crack behavior in Ipseok-dae was 0.367 mm at one point, and showed a slight tendency at other points. One in Jigong Neodeol was within 0.15 mm and showed a stable state with little change. The surface temperature of the Ipseok-dae columnar joints was higher on the side exposed to sunlight than on the shaded side. All blocks of Jigong Neodeol rock showed similar temperatures. The air temperature showed a similar distribution for both rock types. The air temperature showed a similar distribution for both Ipseok-dae and Jigong Neodeol. The relative humidity was mostly between 20% and 60% in Ipseok-dae and was between 20 and 70% in Jigong Neodeol. Both areas had low wind speeds, with maxima of 5 m/s in Ipseok-dae and 3 m/s in Jigong Neodeol. As a result, it is evaluated that crack behavior in Ipseok-dae columnar joints and Jigong Neodeol rock blocks have maintained a very stable state so far. The surface temperature, temperature, relative humidity, and wind velocity of the two areas showed small difference depending on the season, indicating that they were affected to some extent by the season. From a long-term perspective, this can continuously affect the deformation of the Ipseok-dae columnar joints or Jigong Neodeol rock blocks. Therefore, in order to accurately evaluate their stability, it is considered that the current microscopic delamination and exfoliation or the propagation and expansion of cracks should be continuously measured.

• The Journal of the Petrological Society of Korea
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• v.9 no.4
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• pp.254-270
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• 2000

To clarify the geological structure of North Sobaegsan Massif in the Sangunmyeon area, Bonghwagun, Korea, where the Yecheon Shear Zone passes and the NE-SW and E-W trending structural lineaments are developed, the rock-structures of its main constituent rocks(Precambrian Won-nam Formation and Mesozoic Hornblende Granite) were examined. In this area, the geological structure was formed at least by four phases of deformation after the formation of gneissosity or schistosity of the Wonnam Formation: one deformation before D2 ductile shearing related to the for-mation of the Yecheon Shear Zone and two deformations after that. The NE-SW and E-W trending structural lineaments were formed by a giant open or gentle type of F4 fold, and their trends before D4 deformation are interpreted to be parallel to the orientation(ENE-WSW trend) of folded surface in the F4 hinge zone. The structural features of Dl-D3 deformations and their relative occurrence times are as follows. Dl deformation is formative period of the boudin structures and ENE-WSW trending isoclinal folds with sub-horizontal hinge lines and steeply inclined axial surfaces. D2 deformation is that of the mylonite foliation, stretching lineation and Z-shaped asymmetric folds related to top-to-the ENE dextral strike-slip shearing on the distinct foliations of Wonnam Formation(after intrusion of Mesozoic Hornblende Granite). D3 deformation is that of the ENE trending S-shaped asymmetric folds with sub-horizontal hinge lines and axial surfaces related to normal-slip shearing on the distinct foliations. It is expected that the result will be contributed to as valuable data for interpreting the tectonic evolution of the North Sobaegsan Massif and the Northeast Ogcheon Belt whose tectonic lineaments are changed from NE-SW to E-W trends at the Sindong-Bonghwa line.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.9 no.1
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• pp.48-57
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• 2006

Purpose: To investigate the correlation of the serum leptin, adiponectin, and leptin/adiponectin ratio with metabolic disorders in the childhood obesity. Methods: Fifty children (25 obese and 25 non-obese) were recruited in the pediatric outpatient clinic of Chosun University Hospital from January 1st to June 30th 2005. Adiponectin, leptin, anthropometric parameters, glucose, LDL-cholesterol, HDL-cholesterol, total cholesterol, triglyceride, and insulin levels were measured. The correlations of leptin and adiponectin levels with anthropometric parameters, glucose, insulin and lipids were analyzed by Pearson's correlation coefficients. Results: Insulin and leptin levels of the obese group were significantly higher than those of the non-obese group (p<0.05, p<0.001 respectively). HDL-cholesterol and adiponectin levels of the obese group were significantly lower than those of the non-obese group (p<0.005, p<0.05 respectively). In the obese group, leptin level was positively correlated with BMI and the percentage of body fat, but negatively correlated with adiponectin level. Moreover, adiponectin level of the obese group was negatively correlated with BMI and the percentage of body fat, but positively correlated with leptin level. In the non-obese group, only insulin level was positively correlated with adiponectin. In the obese group, leptin/adiponectin ratio was positively correlated with the percentage of body fat and leptin level. Also, leptin/adiponectin ratio was positively correlated with BMI and the percentage of body fat in the non-obese group. Conclusion: Leptin, adiponectin, and leptin/adiponectin ratio did not appear to have a major role linking various metabolic disorders in the childhood obesity, even though they were strongly associated with obesity indices. Also, leptin/adiponectin ratio was associated with obesity indices even in non-obese children.

• The Journal of Engineering Geology
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• v.33 no.3
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• pp.389-401
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• 2023

Climate, weather, insolation (solar radiation), and solar energy in major cities of Tajikistan were investigated prior to construction of infrastructure for the Dushanbe Solar Station. In Dushanbe city there was a 70% probability of sunny days from May 16 to October 23, a period of 5.2 months. August had the most sunny days of in the year, with 99% probability of a sunny, the cloudiest month was February with a 41% chance of being sunny. In major cities of the Sughd and Gorno-Badakhshan states, the average number of cloudy days per month was ~3.3, with Dzhauz having 53 day and Fedchnko Glacier 79 days. For the 18 major cities of Tajikistan, the average annual total solar radiation was 2,429 W/m², and the average monthly solar radiation was 202 W/m². The city with the lowest annual total and monthly average solar radiation was Shartuz in Sughd state, with values ~2.7% less than the national average. The cities with the highest annual total and monthly average solar radiation were Khorog and Jirgatol in Gorno-Badakhshan state, with values ~10% above the national average. The daily average incident shortwave solar energy in the cities Dushanbe, Karakul, and Jirgatol was ~7.8 kWh per 2.4 m² during summer (May-August), and 2.7 kWh during winter (November-February), or ~35% that of summer.