The effects of iodocasein, tapazole, and diethylstilbestrol in the thyroidal activity of chicken were tested. Iodocasein and tapazole were mixed with basal ration at the levels of 0.17 and 0.01 per cent respectively and were fed to one-weeks-old chicken for two months. Six milligrams of diethylstilbestrol were implanted in the subcutaneous tissue. Subsequently 10 uci of radioactive iodine $I^{131}$ were injected intramuscularly into each of the chicken to measure the thyroidal activities of the chicken one month after the treatment was started. The results obtained were as follows: 1) The thyroidal uptake of $I^{131}$ was not observed in the iodocasein group 2) The highest thyroidal uptake rates of I were shown twelve hours after the injection in the all groups except the iodocasein group. 3) The higher thyroidal uptake rates of I were observed in the female chicken than in the male chicken(P<0.01) of the control and the tapazole groups. However, the significant difference between the two sexes was not found in the diethylstilbestrol group. 4) Tapazole at the level of 0.01 per cent of the basal ration of the chicken increased the thyroidal activity slightly.

The serum and erythrocyte cholinesterase activity and their seasonal variations were determined with 8 males of healthy Korean cattles during one year period from September, 1966 to august, 1977. The results obtained were as follows : 1. The serum cholinestrase activity showed a range of 0.64mg/hr/ml to 8.26mg/hr/ml with a mean value of $3.69{\pm}0.25mg/hr/ml$. There was highly significant differences in the seasonal variations. 2. The erythrocyte cholinesterase activity ranged from 29.78mg/hr/ml to 48.88mg/hr/ml with a mean value of $38.37{\pm}1.11mg/hr/ml$. Seasonal variations was not found to be significant. 3. The results showed that the serum cholinesterase activity of Korean cattle had great variations among individual values and significant seasonal variations. On the other hand, cholinesterase activity of erythrocyte showed a little variations among individual values and no significant seasonal variations.

Observations were made to determine the effects of age and season upon the total serum protein values of milk goats(female) and milk cows fed in Korea. The results obtained in this work were summerized as follows; 1. In adults. the average concentrations of total serum protein of milk goats and milk cows were higher than in the younger, and were generally increased with the advance of age. The rate of increase in total serum protein value was more significant in the younger than that of adults. 2. The average concentrations of total serum protein of milk cows were significantly higher than those of milk goats. 3. Seasonal variation of total serum protein value was not observed in milk cows. 4. The average concentration of total serum protein of milk goat fed in Korea was much lower than that reported from the Occident, and this difference seemed to be influenced by the ration low in protein.

Four drugs, bithionol, hexachlorophee, hexachloroethane and tetrachloroethylene, were tested on the in vitro effects of vermicidal and laying capacity inhibitory action to the Eurytrema Pancreaticum of Korean cattle, and the results obtained were as follows : 1) Of the four drugs, bithionol was most effective at both high and low concentrations. 2) The effects of hexachlorophene, hexachloroethane and tetrachloroethylene were less effective than that of bithionol, and the laying activity, at low concentration, was observed to increase at the early stage and decrease gradually thereafter. 3) Tetrachloroethylene was least effective of the four drugs.

This study was conducted to ramify of the splenic arteries by injection of Vinylite into the splenic arteries in twenty five adult Korean cattle. The results obtained are summarized as follows : 1. Splenic trabcular arteries of bovine were originated from 3 chief Rami lienales, Aa. terminales superior et inferior and A. polaris superior, of the splenic arteries, and the splenic parenchyma was ramified to 4-9 arterial segments by the course of the Rami lienales. 2. Each one of the arterial segments was dealt with 2-4 Teilsegmente, therefore, the splenic parenchyma was ramified from 12 Teilsegmente in minimum to 30 Teilsegmente in maximum. 3. The distribution of the arteries in the spleens was divided into 6 types by the number of arterial segments, and also was 15 kinds by the distributing arteries, Aa. terminales superior et inferior and A. polares superior. 4. The anastomosis was not observed between the arterial segments and Teilsegmente.

This study was conducted to ramify of the Rami lienales at the hilus of the spleen in Korean cattle. The materials used were fifty spleens, 25 fresh samples, and 25 Cast specimens. The results obtained are summarized as follows. 1. The splenic arteries were divided into 2 Rami lienales (32 cases, 64%) and 3 Rami lienales(18 cases, 36%). and their branches were nominated as Aa, terminales superior et inferior and A. polares superior. 2. To ramify the A. terminalis superior and A. terminalis inferior, only one case diverged in the splenic parenchyma and 49 cases diverged in the outside of the spleen. 3. Immediately after dividing from the splenic artery to the Aa. terminales superior and inferior, the calibres of the A. terminalis inferior were larger than the A. terminalis superior (sup. 5.5 mm., inf. 8. 5mm.). 4. It was also observed, in all samples used. that Rami lienalis of the splenic artery were not anastomosis in the out side of the spleen.

The arteries in and under the brain of the fowl were invesitigated. Arteries of the brain were injected with neoplen latex into the arteria carotis communis. Those were fixed in 10--- formalin. After fixation, those brain were carefully removed from the cranial cavity doing not wound the arteries of the brain. The results of observation on the arterial supply under the brain surface were essentially the same as those obtained by Hofmann Shiina and Mjyata, Kaku, and Kithoh. The nomenclature of the arteries used by other authers were written in the discussion. In this observation, several conclusions were obtained. 1. In the arteries under the brain of the fowl, their front anastomoses forming the circle of Willis under the brain surface of the mammalia were not seen in all brain. 2. It is very difficult to indicate so called A. cerebri anterior as only one artery ramus. 3. Artery distribution of the two-third in the fissura longitudinal cerebri surface originate from on1y one side in the left or right A. cerebri posterior, and origins of the right side were man number than left. 4. The origin of the A. basilaris originate from only one side R. posterior, therefore their origin were more left than right. 5. There is Rami arteries that branch from A. ethmoidalis to Chiasma opticum in all cases.

Survey of the internal parasites of 1,000 Cheju Cattle was conducted at two slaughter houses in Cheju-Province through a year. The infection rate and distribution of cattle Parasites were surveyed carefully.

The small type piroplasma which is known to be prevailing in Korean cattle was injected to un-susceptible hosts such as mice, guinea pigs, rats, rabbits, fowls and developing chicken eggs by i.v., i.p, and intra C.A.M. routes, and its morphological development in each animal species was observed. 1. The small type piroplasma of cattle did not produce any pathogenicity in the experimental animals such as mice, guinea pigs, rats, rabbits, fowls and developing chicken embryos. However, only a partial sign for developing cycle of the organism was observed in the peritoneal fluid. The schizogony of protozoa was not detected in any organs of the inoculated animals. 2. In the animals inoculated, the parasites of I-III types, relative to the process of time in the host, have changed their shapes into IV-VI types and then VI-X types however, the type X was not restored to the type I. In guinea pigs, more grape type was detected then X type in number, and in process of time, the shape was changed from round to elliptic, and the pointed end of the organism appeared in flesh color. 3. None of the organisms were found from the blood stream of inoculated animals excepts only a few piroplasma as were found in the experimental mice shortly after inoculation or i.v. route, No protozoa was also found in the organs of the animals autopsied. 4. The form change of protozoa was more clear in these animals than that in susceptible host. The most piroplasmas have changed their forms into VI-X types 30 hours after inoculation and were dispersed from R.B.C. Tracing of piroplasrna beyond this stage was not attempted. 5. The small type piroplasma comprises in I. X types and it is further believed that VII-X types which were freed from one cell proceeded to invade others. The from of development resembles to the small type of piroplasma which is prevailing in Japan.

The mature guinea pigs were grouped as indicated in the table 1. Radio-active iodine(I-131)in dose of 4.5mci, was administered to the experimental groups. The animals were killed for examination in 1, 7, 14, 28, 42, and 55 days after the administration the radio-active iodine. The thyroid and adrenal glands were observed histologically. The results obtained were as follows; 1. One day after the administration, thyroid epithelial cells were abnormally enlarged. After seven days, specimens taken from the middle of the thyroid showed that the follicles and epithelial cells were changing to fibrous tissue, however, some follicles still remained in the verge of the thyroid. Follicles were not observed after fourteen days. After twenty-eight days, the follicles had all changed to fibrous tissue, and had lost their function. 2. The size of the zonas gromerulosa of adrenal cortex epually, in both male and female, showed slight fluctuation in size with no tendency to be changed. 3. Among the zones of the adrenal glands, zona fasciculata showed marked changes. Zona fasciculata was atrophied in Process of time. In females, it was atrophied significantly(P<0.05) after fourteen days, and highly significant (P<0.01) in twenty-eight and fifty-six days after the administration of radioactive iodine. In males, it also decreased significantly(P<0.05) in seventy-eight days and highly significant(P<0.01) in forty-two and fifty-six days after the administration. 4. The size of the Zona reticularis of adrenal cortex in the females increased significantly (P<0.05) in twenty-eight days after the administration. In males, it showed slight fluctuation until twenty-eight days, but it increased significantly(P<0.05) in forty-two and fifty-six days after the administration. 5. The size of the adrenal medulla increased significantly(P<0.05) in twenty-eight and forty-two days in females. It was increased significantly(P<0.05) in fourth-two days and high significantly(P<0.01) in fifty-six days after the administration.

Normal value of serum proteins of cockerels and pullets was obtained by seperating serum proteins of 80(♂40, ♀40)immature domestic fowls for routine clinical application purpose, using paper and agar electrophoresis. The concentration count of serum proteins which were fractionated was determined by using densitometer and planimeter. The fractionation value of serum proteins (of cockerels and pullets was indicated in the table 1. The composition of serum proteins by paper and agar electrophoresis showed remarkable differences between cockerels and pullets, but only ${\beta}$-globulin could not found difference between them.

For 8 months, from January to August, 1967, the author made a stuffy of blood total ketones and of korean cattle in different sexes and age groups in winter and summer. The results were summarized as follows : 1. The mean values of blood total ketones and acetone in Korean cattle were $2.31{\pm}0.18mg/dl$ and $0.76{\pm}0.10mg/dl$ in female and $2.35{\pm}0.19mg/dl$ and $0.74{\pm}0.12mg/dl$ in male respectively. 2. The mean values of blood total ketones and acetone during winter season were 2.39mg/dl and 0.84mg/dl in female, and 2.38mg/dl and 0.84mg/dl in male respectively. 3. No statistical significance was recognized among the sexes, the age groups and the seasons by F-distribution. 4. The mean values of blood total ketone and acetone during summer season were 2.25mg/dl and 0.67mg/dl in female, and 2.32mg/dl and 0.64mg/dl in male respectively.

Throughout the studies the following experimental results were summarized. 1. It was impossible to infect and kill the mice, weighing 10 to 12 gm, by inoculating 0.2ml of virulent Cl. chauvoei, diluted 1 to 10 with physiological saline, via subcutaneous, intramuscular, intraperitoneal or intraveonus, route. 2. The mice which were inoculated in brain with 0.03ml of Cl. chauvoei diluted 1 : 5120 with physiological saline were resulted in all death after infection, but not in case of attenuated strain even in dilution of one to five. 3. Virulent Cl. chauvoei were diluted with each of those of whole blood, erythrocytes and serum of horse, calf, swine, sheep, rabbit, guinea pig, chicken and duck, human plasma and 2% CaCl solution, and inoculated subcutaneously 0.25 to 0.5ml in mice, weighing 12 to 15gm. It was resulted in significant increase in virulence as comparing with the case of physiological saline solution except when horse and pig sera were used. Such a phenomena were not seen in attenuated strain. 4. Virulence of virulent Cl. Chauvoei could be increased significantly in rat, as the procedures used in mice, by suspending in whole blood, erythrocytes, serum, or plasma of various animals, or 2% $CaCl_2$ solution and by inoculating subcutaneously 0.5 to 10ml in rat, weighing 30 to 60 gm, as compared with those of control group which used physiological saline solutionos diluent. 5. Mice resisted 100 and 80 percent against challenge of $10^3$ and $10^4$ M.L.D.. respectively, 24 hours after inoculation of 0.5ml black leg antiserum. 6. Immune response to the black leg living vaccine in mice could be obtained more favorably in the group of respected vaccination rather than those of single inoculation and the most profitable inoculm size of the vacine was 0.5 to 1.0ml. 7. Challenge for the immunized mice could be carried out effectively 3 weeks after first vaccination. 8. Satisfactory results could be obtained by inoculating subcutaneously for the immunization and intracerebrally or subcutaneously for the challenge. 9. Mice which were inoculated with 0.5ml of black leg living vaccine via subtaneucously two times at seven days interval and 21 days after first inoculation and challenged with 5 and 10 M.L.D. of virulent strain, resited 100 and 70 to 80 percent respectively. Same results were obtainable in black leg killed vaccine as the procedures used in living vaccine. 10. There were significantly different resistances against the definite challenge does between the mice groups which were immnuized with the living vaccine diluted five or 10 times and the undiluted. 11. For the biological assay of black leg living vaccine and antiserum, satisfactory results could be obtained using mice.

1. Of the three kingdoms, Koguryo is believed to have had nomadic life, so the livestock husbandry was vigour, but, in Silla and Paikche, only the horse production as military purpose and cattle production as a mean of cultivation had been improved. 2. In the three Kingdoms, the methods of superstition and Shamanism had been used as the mean of curing animals before Haeza, a saintly priest, A. D 590. and after that, shamanism and veterinary science seemed to be combined. We believed that Haeza is to be an initiator of veterinary science in Korea.