Depressive disorder is a chronic disabling condition with recurrent episodes. Medication noncompliance is a significant problem for effective management of depressive disorder. However, compliance with antidepressant medication is poor. There are difficulties in assessing compliance accurately. Various methods for assessing compliance are in use. A patient's compliance with antidepressant may be affected by many factors including the clinical characteristics of depression, pharmacologic properties of antidepressants, patients' characteristics, accessibility treatment, and doctor-patient relationships. For enhancing the treatment compliance, psychotherapeutic considerations in patient-therapist relationship are needed.

Objectives : The Big Five Inventory(BFI) and the Big Five Inventory-10(BFI-10) are widely used instruments for the evaluation of personality in various cultures, while they have not been formally validated in Korea. This study aimed to develop the Korean versions of BFI(BFI-K) and BFI 10(BFI-K-10) with a Korean elderly population. Methods : The study sample consisted of 1,038 community dwelling elders. BFI-K and BFI-K-10 were administered. For the reliability analyses, scores on Guttmans' split half and Cronbach's ${\alpha}$ were estimated. For the validity analyses, the Korean version of Geriatric Depression Scale(KGDS) and the State-Trait Anxiety Inventory(STAI) were investigated. Results : The reliability of the BFI-K was good(Guttmans' split half=0.59-0.78, Cronbach's ${\alpha}$=0.52-0.75). Scores on the BFI-K-10 were significantly correlated with the scores on BFI-K. Scores on the BFI-K and the BFI-K-10 were significantly correlated with the scores on KGDS and STAI. Conclusion : Both BFI-K and BFI-K-10 might be reliable and valid instruments to evaluate the personality in Korean community elders. BFI-K-10 is short and easy to be administered, and therefore it would be very convenient to use.

Objectives : It is well-known that Korean people show distinctive drinking behaviors depending on the gene polymorphisms of alcohol metabolizing enzymes. This study examined the gene polymorphisms of ALDH2 and ADH1B and their combination on the drinking behaviors of Korean young adults. Methods : Through a follow-up survey performed for a cohort consisting of 551 university freshmen for six years, the authors attempted to identify genetic factors affecting drinking behaviors. In 2000, drinking behaviors and scores of CAGE questionnaires were assessed and ALDH2 gene polymorphism was determined with PCR-RFLP. In 2006(n= 150), AUDIT-K was assessed in addition to the above and gene polymorphism of ADH1B was determined through SNaPshot$^{TM}$ method. Results : While ALDH2*2 allele was associated with increased degree of drinking in 2000 and 2006. When both enzymes were active, the possibility to be classified into the risk group for alcohol dependence such as AUDIT-K(>12), and CAGE(>2) was high. Conclusion : The ALDH2 genotype had a significant effect on drinking behavior and degree of drinking during early adulthood. However, the combination of the active form of ADH1B and the active form of ALDH2 can be risk factor for problem drinking.

Objectives : The $2^{nd}$ to $4^{th}$ digit length ratio(2D : 4D) is a sexually dimorphic trait regardless of ethnicity and shows sex differences. According to previous research, men usually have a relatively shorter $2^{nd}$ digit than $4^{th}$ digit. There is tendency that men with lower 2D : 4D are perceived as being more masculine and tend to perform better in some physical sports. Furthermore, 2D : 4D is negatively associated with trait aggression. In this study, we examine gender difference of 2D : 4D and compare 2D:4D of female Korean national team members to 2D : 4D of control subjects. Besides that, we also compare 2D : 4D of female Korean national team members according to their sports entries. Methods : The sample of this study is 396 people, 67 female Korean national team member, 216 control women and 113 control men. We measured $2^{nd}$ to $4^{th}$ digit length of their right hand. In addition, we collected demographic information of female Korean national team members using a self-report questionnaire. Results : The mean 2D : 4D of female Korean national team members is 0.96(SD=0.04), smaller than control women's 2D : 4D(0.97, SD=0.03) and significantly higher than control men's 2D : 4D(0.95, SD=0.03). We also found differences between control men and women. Non-martial arts related sports athletes have significant difference with control men in 2D : 4D. However, martial arts related sports athletes' 2D : 4D is not significantly different from other groups, including control men. Conclusion : These results are consistent with the findings of previous research that there is a significant difference between men and women in their 2D : 4D. Furthermore, 2D : 4D of martial arts related sports athletes have not shown any difference from the 2D : 4D of control men that 2D : 4D of non-martial arts related athletes have shown. This fact is important in consideration of masculine characteristics. For further research, it is necessary to examine 2D : 4D difference according to sport ability and gender differences.

Objectives : Social phobia is frequently accompanied with autonomic nerve system symptoms. QT dispersion(QTd) is the maximum inter-lead difference in QT interval, an indicator of the autonomic nerve system(ANS) disparity of the heart itself. The objective of this study is to investigate the ANS disparity, which is measured by QTd, is associated with pathophysiology of social phobia. Methods : This research have compared QT dispersion of 25 physically healthy social phobia outpatients(16 men, 9 women, the average age $35.5{\pm}12.9$) and age and sex matched control group of mentally and physically healthy 25 volunteers(16 men, 9 women, the average age $34.83{\pm}12.7$). QTd was measured by previously described method. Results : QTd and rate-corrected QTd were significantly higher on the patient group than the control group[QTd(patients vs. controls : $52.60{\pm}27.63ms$ vs. $27.53{\pm}14.29ms$, p<0.0001), QTd(patients vs. controls : $55.79{\pm}27.98ms$ vs. $29.10{\pm}14.24ms$, p<0.0001)]. Conclusion : Our study showed that the patients with social phobia have higher QTd than the normal controls. These results suggest that the ANS disparity, which is measured by QTd, is associated with pathophysiology of social phobia.