Purpose - The artificial intelligence industry plays an increasingly significant role in stimulating the development of United States of America's economy. On account of this background, this paper attempts to explore the impact of artificial intelligence industry on United States of America's macroeconomy. Research design, data, and methodology - This paper mainly focuses on the impact of artificial intelligence industry on GDP, employment, real income, import, export and foreign direct investment. Furthermore, the Phillips-Perron test and Canonical cointegrating regression will be employed to examine the impact of artificial intelligence industry on United States of America's macroeconomy with a sample form 2010-Q1 to 2017-Q4. Results - Via the empirical analysis, the results reveal that the artificial intelligence industry has a positive effect on United States of America's GDP, employment, real income, export and foreign direct investment. Conversely, the artificial intelligence industry has a negative effect on United States of America's import. Conclusions - In summary, the impact of artificial intelligence industry on United States of America's macroeconomy is positive and significant in statistics. Therefore, the government of United States of America should put more input into artificial intelligence industry.