Purpose: The greatest asset to all organizations is the employees and they should be guarded against factors hindering their work ability. Nevertheless, most organizations are always more concerned about making profits to the extent of forgetting their employee's welfare. On this point, this study aims to examine employee's work-related stress and its relationship with work ability. Research design, data and methodology: This study focused on obtaining mostly peer-reviewed works to suggest research findings, assuming that qualitative literature approach allows researchers to explore in-depth information concerning complex issues in a standard life setting. Numerous prior researchers applied their research design in content analysis, especially where various concepts are present for analysis. Results: Based on numerous qualitative textual resources, this study found that human resource practitioners should plan stress management strategies for their employees to apply five kinds of solutions that the current study suggests because it is vital to ensure their wellbeing towards sustaining their performance. Conclusions: All in all, based on the findings, this study concludes that employee's work stress negatively impacts their work ability with affecting their mental health. As a result, there is little doubt that practitioners should regularly monitor the working environment for stress-related factors besides creating a healthy working environment for all employees.