This article presents a study of the largest-ever (height = 220 m) cooling tower using the large eddy simulation (LES) method. Information about fluid fields around the tower and 3D aerodynamic time history in full construction process were obtained, and the wind pressure distribution along the entire tower predicted by the developed model was compared with standard curves and measured curves to validate the effectiveness of the simulating method. Based on that, average wind pressure distribution and characteristics of fluid fields in the construction process of ultra-large cooling tower were investigated. The characteristics of fluid fields in full construction process and their working principles were investigated based on wind speeds and vorticities under different construction conditions. Then, time domain characteristics of ultra-large cooling towers in full construction process, including fluctuating wind loads, extreme wind loads, lift and drag coefficients, and relationship of measuring points, were studied and fitting formula of extreme wind load as a function of height was developed based on the nonlinear least square method. Additionally, the frequency domain characteristics of wind loads on the constructing tower, including wind pressure power spectrum at typical measuring points, lift and drag power spectrum, circumferential correlations between typical measuring points, and vertical correlations of lift coefficient and drag coefficient, were analyzed. The results revealed that the random characteristics of fluctuating wind loads, as well as corresponding extreme wind pressure and power spectra curves, varied significantly and in real time with the height of the constructing tower. This study provides references for design of wind loads during construction period of ultra-large cooling towers.