Purpose: The study was done to verify evidence-based practice (EBP) readiness and factors contributing to EBP competency in general hospital nurses. Methods: Participants were 219 nurses working in 7 general hospitals in G-city and J Province. Data were collected from May 12 to May 28, 2015 and analyzed using one-way ANOVA, Pearson's correlation and stepwise multiple regression. Results: Mean score for EBP competency was 3.89±0.83, for critical thinking disposition, 3.35±0.36, for EBP attitude, 3.53±0.66, for beliefs about value of EBP, 3.42±0.56, for ability in research performance, 2.86±0.57, for time to devote to EBP, 2.57±0.69 and for organization support for EBP, 3.36±0.46. EBP competency was significantly correlated with critical thinking disposition (r=.37, p<.001), beliefs about value of EBP (r=.43, p<.001), ability in research performance (r=.44, p<.001), and time to devote to EBP(r=.33, p<.001). Factors influencing EBP competency in general hospital nurses were research performance (β=.29, p<.001), beliefs about value of EBP (β=.24, p<.001), critical thinking disposition (β=.15, p=.014), recognition of EBP (β=−.18, p=.002), which together explained 35% of total variance. Conclusion: Findings indicate that introduction and activation of EBP in general hospitals is essential and development of systematic training programs to strengthen critical thinking disposition and EBP competency are needed.