Purpose : The purpose of this study was to identify the factors influencing the general hospital nurses' confidence about the advance directives (ADs). Methods : This is a descriptive cross-sectional study. A total of 105 nurses were asked questions about characteristics, knowledge, attitude, learning needs, and confidence the about ADs, using structured questionnaires. Data were analyzed by descriptive statistics, t-test, ANOVA, Pearson's correlation coefficient, and multiple regression. Results : The mean scores of knowledge were 7.26±1.47; attitude, 2.80±0.31; learning needs, 4.22±0.62; and confidence, 2.57±0.74. It was observed that knowledge had significant correlations with attitude (r=.43, p<.001), learning needs (r=.29, p=.003), and confidence (r=.40, p<.001), and attitude had significant correlations with learning needs (r=.31, p=.001) and confidence (r=.45, p<.001). Using multiple regression analysis, it was found that confidence was significantly influenced by knowledge (β=.27, p=.007), attitude (β=.21, p=.043), and experience of nursing or counseling a patient who wrote ADs (β=-.19, p=.046). The explanatory power of this model was 37.9% (F=5.16, p<.001, R2=.379). Conclusions : These findings suggest the need to develop a program to enhance nurses' knowledge, positive attitude, and experience of nursing or counseling a patient who wrote ADs.