One of the innovative and most promising approaches to new high-tech business formation from university is technology business incubators, which attempts to enhance small high-tech start-up firms' chances of survival. To date, there is few comprehensive effort to do a comparative study of technology business incubatiors between European Countries and U.S. to evaluate the impacts of them on regional development. With these consideration in mind this research anlayzed key findings of 6 case studies of university related Technology Business Incubators in the U.K., Germany, and U.S. to explore relationship of university to regional development. These included Cambridge Science Park(CSP) '||'&'||' West of Scotland Science Park in the U.K., Dortmund Technologiezentrum '||'&'||' Berlin Technologiezentrum, and Rensselaer Technology Development Center of the Georgia Institute of Technology in the U.S. The primary objective of this study was to advance our understanding of the impact and utility of technology business incubators and to get some policy implications for the future development in this area in Korea. Among the major question examined hear was "how do they contribute the overall economy of the communities in which they are located\ulcorner". The results of the case study about this question were very positive. The technology business incubators contributed to foster new high-tech small business formation from university, to facilitate the cooperation between university and industry and Incubator tenants created jobs and income, pay taxes, and in doing so, had a multiplier effects on the local economy. The same was true of incubator graduates. With this consideration in mind the university related business regioned development policy in korean local communities.