권호 표지

약학회지 (YAKHAK HOEJI) (YAKHAK HOEJI)

대한약학회 (The Pharmaceutical Society of Korea)

  • 격월간
  • /
  • 0377-9556(pISSN)
  • /
  • 2383-9457(eISSN)

과학기술표준분류

  • 보건의료 ＞ 의약품/의약품개발

Aim & Scope

Yakhak Hoeji is an official domestic journal of the Pharmaceutical Society of Korea and has been published since 1948. Yakhak Hoeji is a peer-reviewed journal devoted to all areas of pharmaceutical sciences including basic, translational, clinical, and pharmacy-related social studies. This journal aims to represent the academic output on pharmaceutical sciences and pharmacy practice to build an academic exchange platform among pharmaceutical scientists, researchers, and pharmacists so that the readers could update the recent scientific knowledge and academic trends, ultimately leading to further development on the pharmaceutical sciences. Manuscripts will be considered for publication on the condition that the results reported are based on research works that has not been published elsewhere in any journal.

https://www.psk.or.kr/home/kor/article/submission/submission_login_form.asp?globalmenu=3&localmenu=4 KSCI KCI

제24권3_4호

  1. 김영중;김은경 143
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    The effect of ginseng saponin on chick embryonic dorsal root ganglia organ culture and brain, spinal cord, muscle dissociation cultures was studied. The fiber outgrowth in explanted chick embryonic dorsal root ganglia was markedly induced by water and alcohol extracts of ginseng, total ginseng saponin, protopanaxadiol and protopanaxatriol glycosides as well as ginsenosides R/sub b1/, R/sub d/, R/sub 0/+R/sub a/+R/sub b1/, and R/sub b2/+R/sub c/+R/sub e/ mixtures. The life span of the cultured chick embryonic dorsal root ganglia and potentiation of nerve cell density were also observed with all of these ginseng saponins. The effect of ginseng saponin on chick embryonic dorsal root ganglia organ culture was more marked in the absence of the chick embryonic extract which was known to contain nerve growth factor-like material in the culture media. However, the ginseng saponin did not influence the cultured central nervous system such as brain and spinal cord cells and cultured skeletal muscle cells with respect to the morphological changes, maturation and life span of these cells.
  2. 이왕규;유경수 151
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    Color transition mechanism of shikonin as an acid-alkali indicator was studied. It was confirmed that the presence of phenolic hydroxy radical was essential for the color change of shikonin. But in accordance with shikonin sodium salt (blue color), which was presumed to make chelation as six membered rings. Shikonin in alkaline solution, by dissociated phenolic protons of naphthoquinone nucleous, converted to the corresponding anion and instead of disappearance tautomerization, electron delocalization occurred and an additional pair of nonbonding electrons in the anion was available for interaction with .phi. electron system of the ring with further extension of the conjugation. It was responsible for its blue color(corresponding color: orange) with needs less energy difference (${\phi}{\rarw}{\phi}^{*}$) because of conjugation extension. Shikonin sodium salt seems to have similar nuclear structure as shikonin anion.
  3. 엄동옥;이윤중 159
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    Tetrathiocyanatocobaltate[II] forms complexes with tertiary amine salts or quarternary ammonium salts which were extractable from aqueous solution by organic solvent. In order to study composition of the complex, the colored crystalline complexes produced were evaluated with elemental analysis, infrared and mass spectra. And also a novel spectrophotometric method for the determination of tertiary amine salt or quarternary ammonium salt with tetrathiocyanatocobaltate[II] was established by organic solvent extraction within coefficient of variation of 1.06-1.35%.