Purpose: This study was conducted to develop a simulation-based education program for newborn emergency care based on most needed topics found from the needs assessment. This study consisted of two phases: developing the program and evaluating its effectiveness. Methods: The effectiveness of the program was tested in July, 2012, with 49 junior nursing students from C Nursing College in Seoul, who did not have any clinical experience in newborn care. The experimental group was given a three-hour lecture, three hours of clinical training, and a two-hour simulation program, whereas the control group only had the three-hour lecture. Results: There was significant improvement in knowledge in both groups, but no significant differences according to educational methods. The experiment group was more confident of their care ($4.32{\pm}.29$) than the control group ($3.60{\pm}.29$) with the difference being significant (t=8.85, p<.001), and the experimental group was also more satisfied with the program (${\chi}^2$=4.60, p=.032). Conclusion: As the results indicate 'the neonatal emergency care program' increased learners' knowledge, confidence and satisfaction with the program, it should be integrated into clinical training in pediatric nursing curriculum and in-service programs for nurses. To increase generalization further verification studies with various learner groups are needed.