The quantitative analyses of the phosphatase activity in the endometrium of the rat ovariectomized on Day 2 of pregnancy was carried out in comparison with the intact one, in order to investigate the hormonal dependency of the uterus prior to the implantation, and to study the phosphatase activity in the endometrial tissues in vitro incubated in different acidity of the medium. The results obtained were as follows: 1. The activity of the total phosphatase was the highest at Day 3 of pregnancy of the intact animals irrespective of acidity of the medium. However, the ovariectomized rat showed its peak somewhat delayed. The time of the highest activity of the enzymes was matched with the time of high secretion of the ovarian hormones. 2. The activity of acid phosphatase in the endometrium was twice or four times as much high as that of neutral or alkaline phosphatase, respectively. 3. The activity of alkaline phosphatase was rather steady in Day 3 through Day 5 of the pregnancy of the rat intact or ovariectomized but with low level compared to those of other phosphatase. 4. The present re~lt indicated more important role by $Mg^{2+}$-dependent phosphatase than by $K^+$-dependent one for the preparation for decidualization.

정자의 아크로좀에 존재한다고 알려진 효소들중 실온에 방치할 경우 또는 완충용액으로 정자를 세척할 경우 쉽게 아크로좀 막으로부터 흘러나옴을 관찰하였다. 신선하게 사용된 토끼의 정액을 $0^{\circ}C$에서 트리스 완충용액에 방치할 경우 하이얄유로니데이스는 39%정도가 유출되어 나오고, 또 $37^{\circ}C$에서 1시간 더 둘 경우 나머지 30%, 그리고 두시간째에 17%가 방출되며, 계면활성제로 아크롬을 처리할 경우 단 4%의 효소가 추출되었다. 다른 두 탄수화물 분해요소인 베타 엔 애시틸글루코사미니데이스 및 베타 그룩유로니데이스도 하이얄유로니데이스처럼 쉽게 분리되어 나오고 계면활성제로 추출될 수 있는 양은 대단히 적었다. 이와같이 효소가 아크로좀에서 방출되는 정도에 따라 아크로좀막에 흡착된 정도를 알 수 있으며 동시에 수정과정에서 역활을 이해하는데 도움이 될 것이다.

Vesectomy has been increased as a popular method of birth control because it is simpler than other methods for men. But the vasectomy results in several problems such as relation to effect changes on the structure and function of the reproductive organ. The fate of non-ejaculated spermatozoa is postulated by some authors that those are disappeared by a progress of dissolution and reabsorption in the epididymis, and we have attempted to prove the true state of sperm-acrosome on the fine structure in vasectomized rats. The results were as follows: 1. Apical segments of the acrosome were swollen similar to the shape of club in many spermatozoa. 2. Discontinuities of the outer and inner acrosomal membranes were occasionally noted and there were complete losses of acrosomes in the certain place. 3. There was no evidence of significant changes in the nuclear structure, nor dilatation of the subacrosomal space. 4. Vasectomy might effect destructive changes in the acrosomes of the non-ejaculated spermatozoa in situ.

In order to evaluate the clinical utilization and efficacy of X-ray pelvimeter, a study of selective information from 292 cases, who had clinical and X-ray pelvimetry, among 7346 single term deliveries in the years 1975 and 1978 was undertaken in Yonsei University Medical Center. The results revealed that there were no significant statistical difference between X-ray and clinical pelvimetry groups in terms of the outcome of labor and in regard to determining the pelvic size (p > 0.05). Most X-ray examination which caused significant fetal exposure were pelvimetries.

Clomiphene citrate. antiestrogen, was given to 39 infertile males whose spermatogenesis were disturbed and the efficacy of the drug was evaluated at the Department of Urology in 1980. (Table 1). Patients were divided into 3 clinical observation groups such as group I composed of 19 cases of idiopathic azoospermia, group II consisted of 15 cases of oligospermia following the vasovasostomy, and group III comprised 5 cases of testicular azoospermia. (Table 2). Clinical characteristics of these patients were as follows: Age of the patients ranged from 26 to 43 years old with mean of 34, and that of their wives ranged from 24 to 41 years old with mean of 31. Duration of marital life ranged from 1 to 21 years with mean of 5 years. Sizes of testis ranged from 6 to 25 ml with mean of 16 ml. Coital frequency ranged from 0.5 to 6 per week with mean of 2.4 per week. Levels of plasma FSH ranged from 3.15 to 23.06 lU/1 with mean of 8.15 lU/1, those of LH ranged from 2.98 to 19.89 lU/1 with mean of 8.18 lU/1 and those of testosterone ranged from 3.09 to 9.97 ng/ml with mean of 6.48 ng/ml. (Table 3). Clomiphene citrate was given in dosage of 50 mg per day (in d.) orally to 31 patients for 3 to 9 months and in dosage of 100 mg per day (b.i.d.) orally to 8 patients for 3 to 9 months. (Table 8). Semen samples were analysed monthly on each patient by routine analysis techniques. For the assessment of the efficacy of Clomiphene citrate on faulty spermatogenesis following empirical criteria were used: For semen quality: Improvement (I) represents that semen parameter increased more than 25% from basal level after the treatment, Unchange (U) expresses that semen parameter increased less than 25% of basal level or not changed after the treatment and Deterioration (D) means that semen parameter decreased from basal level after the treatment. For fertility unit (total counts ${\times}$ motility ${\times}$ morphology ${\div}10^6$): Improvement (I) represents that fertility unit increased more than 10 units after the treatment, Unchange (U) expresses that fertility unit increased less than 10 units or not changed after the treatment, and Deterioration (D) means that fertility unit decreased after the treatment. (Table 4). Results obtained from the Clomiphene therapy were as follows: Changes of spermiograme before and after the Oomiphene therapy shown in the Table 5. Sperm counts increased from 23 to 31 ${\times}10^6$/ml in group I, from 17 to 29 ${\times}10^6$/ml in group II. Other parameters of spermiogramme were not changed significantly after the treatment. Fertility units increased from 14 to 18 units after the treatment in group I, and from 16 to 18 units after the treatment in group II. Effectiveness of Clomiphene citrate on spermatogenesis was summarised in the Tables 6 and 7. After the treatment, sperm count increased in 11 patients, motility increased in 6 patients, morphology increased in 4 patients and fertility units increased in 9 patients. No sperm could be produced by Clomiphene citrate in group III of testicular azoospermia. Dosage of 50 mg of Clomiphene citrate per day for 3 to 6 months was proved to be the most effective in the present series. (Table 8). Pregnancy occurred in 2 patients after the treatment. No particular side effects were noted by the treatment. Pharmacologic compounds used for male infertility were shown in the Table 9. Reported results of Clomiphene citrate were shown in the Table 10.