뇌하수체의 성선자극 홀몬 분비 세포는 혈액내 estradiol양의 변화에 따라 LH와 FSH를 분비하므로써 주기적인 변화를 보인다. 성선 자극 홀몬의 분비는 성선 자극 홀몬을 합성하고 보유하는 두가지 형태의 능력의 크기에 의하여 조절되며 이들을 조절하는 것은 시상하부에서 분비되는 황체형성 홀몬-분비 홀몬(LH-RH)과 난소에서 분비되는 estradiol이다. LH-RH는 성선 자극 홀몬 분비세포에 작용하여 성선 자극 홀몬 합성, 저장 및 분비를 촉진시키며 estradiol은 LH-RH의 기능을 확대하고 LH-RH가 self-priming효과를 나타내도록 유도하기도 하며 LH-RH의 성선 자극 홀몬 분비 기능을 저해하기도 한다. Estradiol은 기저성 성선 자극 홀몬을 분비시키기 위하여 negative feedback작용을 하고 배란성 성선 자극 홀몬을 분비시키기 위하여는 positive feedback작용을 하며 feedback작용 부위는 시상하부 및 뇌하수체 전엽이다. 또한, estradiol이 feedback작용을 하여 성선 자극 홀몬의 분비를 조절하는 데는 LH-RH뿐만 아니라 중추신경-시상하부에서 분비되는 dopamine, norepinephrine, prostaglandin등이 참여한다.

Hysterosalpingograms (H.S.G.) have been done for several decades to determine causative factors in female infertility. However, the H.S.G. only reverals uterine cavity and tubal patency or inpatency. The author prefers to find more details in regard to the status and condition of the female reproductive organs and their surrounding tissue as they pertain to infertility. H.S.G. in combination with laparoscopic examination reveals the following results. Preparation and method of performance of H.S.G. during laparoscopy in a healthy reproductive age women are as follows. When laparoscopy is not contraindicated, NPO is ordered with routine bowel preparation. Analgesics administered by injection prior to procedure are valium 10mgs and pethidine 50-100mgs. The radiographic procedure is the same as for any HSG technique. During laparoscopy a solution of 3 to 10 ccs. of 60% hypaque sodium is used. Fluroscopic scout films are obtained A-P and oblique views as well as a delayed check film. 1. Age distribution of primary and secondary infertility in this studies involving tubal factors was as follows: 20-29 age group showed 46% incidence and in the 30-39 age group, 50% incidence. Duration of infertility in this study group was the following: 1-2 years showed 26.7%, 3-5 years 53.8%, and 6-9 years 13.3%. 2. Indications of laparoscopic examination were as follows: Secondary infertility in 35% of the cases, obscure tubal occlusion on previous H.S.G. in 25%, unknown origin in 11.7%, and the remaining cases included pelvic pain, small masses, dysmenorrhea, and uterine anomaly. The laparoscopic examination showed clearly the reproductive organs and the surrounding tissues in the pelvic cavity. The abnormal tubal findings there revealed were tuberculous salpingitis and hydrosalpinx in 10% each, endometriosis and peritubabl adhesions in 6.7% each, biconuate uterus in 3.3%. The remaining 58.3% of the cases showed normal findings. Laparoscopic observation for possible myoma nodules, streak ovary, and peritubal adhesions was also done at this time. 3. Comparative tubal findings in combined H.S.G. and laparoscopic examination revealed the following. Bilateral tubal occlusion was present in 14% (7cases) on laparoscopic examination but on H.S.G. 38% (19 cases) were noted. However, tubal occlusion and peritubal adhesions were found in 26% (13 cases) upon laparoscopy and only 8% (4 cases) on H.S.G. examination alone. Normal pelvic findings were present in 60% (27 cases).

The status of artificial insemination was surveyed by investigating 20796 heads of adult dairy cattle out of 30464 heads at 1649 dairy farms located Seoul and Gyung-Gi and Chung-Cheong province area, and the results are as follows: 1. There were 286 small farms feeding less than 5 heads occupying 17.3% of total farm number, and 1083 medium sized dairy farms feeding between $6{\sim}20$ heads occupying 65.64% and also 280 large dairy farms feeding more than 21 heads occupying 17.06% of total. 2. Population of cow aging from 2 to 6 years were 87.26% and among 20907 heads of dairy cattles which had calved previously 13196 heads had histories of one to four calving 90.40%. 3. The successful conception rate with first A. I. occupied only 53.43% and 92.4% after third A. I. service. The average A. I. frequency for successful conception per/head was 1.8 times. 4. The breeding status was pregnancy 61.72%, uncertain pregnancy 19.39%, and as physiological vacancy 12.48% and reproductive disorders 10.62%. 5. Among 1264 heads of reproductive disorders 856 heads were clue to ovarian diseases and occupied 68.98% of total disorders and uterus diseases 10.64% and repeat breeders occupied 17.64%.

Korean family planning program has been adopted as a part of the Economic Development Plan with strong national government backup. After initiation of family planning program, the increase rate of total population declined from 2.6 percent during 1955-1960, to 2.1 percent in 1960-1975, and 1.6 percent in 1979. Of course, we do not ascribe this population increase rate decline to the national family planning program alone. Other contributing factors have been changes such as growing numbers of induced absortions, a rising marriage age and economic development. Currently, 2,600 family planning workers are assigned in all myun of the country. 21 percent of the works are registered nurse, 9 percent are midwife and aid nurses occupy 70 percent (Table 1). Authorized clinics are 2,329 which composed 1,765 IUD clinics, 1,070 vasectomy clinics and 1,150 Fimale sterilization clinics (Table 2). Cumulative contraceptive services provided by government program, 1962-1974 is illustrated in Table 3. After government program in family planning has been initiated (1962-1978), estimated number of births averted by each methods was measured (Table 4). From 1962 to 1978, tendency of contraceptive acceptors is illustrated in Table 5 showed that IUD, oral pill and condom program is decreasing and in other hand, sterilization program is increasing very much. Attitude change toward family size (1965-1978), contraceptive practice and son preference are showed in Table 7, 8, respectively. Auther concluded that future program in family planning should target to the point, that smaller family size norm for maternal health should be emphasized rather than smaller size family for national development.