Objectives The aim of this study was to systematically review and analyze the clinical efficacy of Chuna Manual Therapy (CMT) for the treatment of Sacroiliac Joint Syndrome (SIJS). Methods A comprehensive literature search was conducted up to April 2024, utilizing databases such as PubMed, EMBASE, The Cochrane Library, CNKI, ScienceON, Kmbase, OASIS, RISS, and KISS. Studies were selected based on the PICOS criteria: Participants (patients with SIJS), Intervention (CMT), Control (various treatments), Outcomes (pain and functional improvements), and Study design (randomized controlled trials, RCTs). The Risk of Bias (ROB) was assessed using the Cochrane ROB tool, and data were analyzed using Review Manager 5.4.1. The primary outcomes were pain reduction measured by Visual Analogue Scale (VAS) and treatment efficacy rates. Results Out of 330 identified studies, 10 RCTs involving 776 patients met the inclusion criteria. The selected studies compared CMT with acupuncture, pharmacotherapy (celecoxib), and physical therapy. Meta-analysis showed that CMT significantly reduced pain compared to physical therapy (p<0.00001). When compared with pharmacotherapy, the results indicated no statistically significant difference (p >0.05). Combined treatments of CMT with other modalities such as acupotomy and cupping showed enhanced efficacy rates and pain reduction, suggesting synergistic effects. Conclusions The review indicates that CMT is effective in reducing pain and improving function in patients with SIJS, especially when compared to physical therapy. However, the study also highlights the need for larger sample sizes and longer follow-up periods to validate these findings. Additionally, future studies should address the challenges of blinding in manual therapy trials to mitigate bias risks. Despite these limitations, CMT appears to be a viable option for the treatment of SIJS, with potential for enhanced outcomes when combined with other therapeutic modalities.