Allergy, Asthma & Respiratory Disease

  • 제12권3호
  • /
  • Pages.155-159
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  • 2024
  • /
  • 2288-0402(pISSN)
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  • 2288-0410(eISSN)
대한천식알레르기학회 (The Korean Academy of Asthma, Allergy and Clinical Immunology)
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Cerebral toxoplasmosis in a patient with Good's syndrome: A case report and literature review

  • Seoyoung Choi (Department of Internal Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine) ;
  • Mi Jung Kwon (Department of Pathology, Hallym University Sacred Heart Hospital, Hallym University College of Medicine) ;
  • Eun Soo Kim (Department of Radiology, Hallym University Sacred Heart Hospital, Hallym University College of Medicine) ;
  • Heui Seung Lee (Department of Neurosurgery, Hallym University Sacred Heart Hospital, Hallym University College of Medicine) ;
  • Younghee Jung (Division of Infectious Diseases, Department of Internal Medicine, Chungnam National University Hospital) ;
  • Joo-Hee Kim (Department of Internal Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine) ;
  • Seung Hun Jang (Department of Internal Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine)
  • 투고 : 2023.10.16
  • 심사 : 2024.01.04
  • 발행 : 2024.07.30
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초록

Good's syndrome is a rare cause of combined B- and T-cell immunodeficiency in adults with a history of thymectomy. The patients with Good's syndrome are susceptible to encapsulated bacterial infections and opportunistic viral/fungal infections. We report a 63-year-old female patient who was diagnosed with cerebral toxoplasmosis in the middle of monthly immunoglobulin treatment for Good's syndrome. She was referred owing to progressive dizziness for one week without any neurologic deficits. Although routine laboratory tests and toxoplasma serology exams were within the normal range, brain image studies suggested cerebral toxoplasmosis, which was confirmed by pathology of brain lesions. She was treated with pyrimethamine and sulfadiazine as well as with systemic corticosteroids, and improved without sequelae. Later, her medication was switched to trimethoprim/sulfamethoxazole as a second-line treatment due to sulfadiazine-related neuropathy.

키워드

과제정보

This work was supported by a research grant (NRF-2021-R1I1A3050318) from the National Research Foundation (NRF) of Korea.

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