Allergy, Asthma & Respiratory Disease

  • 제12권4호
  • /
  • Pages.184-189
  • /
  • 2024
  • /
  • 2288-0402(pISSN)
  • /
  • 2288-0410(eISSN)
대한천식알레르기학회 (The Korean Academy of Asthma, Allergy and Clinical Immunology)
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구운 달걀과 우유 섭취가 소아기 IgE 매개 식품알레르기 경과에 미치는 영향

The effect of baked egg and milk consumption on IgE-mediated egg and milk allergies in young children

  • 강지민 (성균관대학교 의과대학) ;
  • 김수경 (성균관대학교 의과대학 삼성서울병원 소아청소년과) ;
  • 송정민 (성균관대학교 의과대학 삼성서울병원 소아청소년과) ;
  • 신상희 (중앙대학교 의과대학 중앙대학교병원 소아청소년과) ;
  • 안강모 (성균관대학교 의과대학 삼성서울병원 소아청소년과) ;
  • 장세헌 (성균관대학교 의과대학 삼성서울병원 소아청소년과) ;
  • 김지현 (성균관대학교 의과대학 삼성서울병원 소아청소년과)
  • Jimin Kang (Sungkyunkwan University School of Medicine) ;
  • Sukyung Kim (Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Jeongmin Song (Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Sanghee Shin (Department of Pediatrics, Chung-Ang University Hospital, Chung-Ang University College of Medicine) ;
  • Kangmo Ahn (Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Sehun Jang (Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Jihyun Kim (Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine)
  • 투고 : 2024.05.23
  • 심사 : 2024.06.17
  • 발행 : 2024.10.30
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초록

Purpose: We aimed to evaluate the effects of baked egg and milk diets on the prognosis of immunoglobulin E (IgE)-mediated food allergy in young children. Methods: In this retrospective study, we enrolled children under 36 months of age who were diagnosed with egg or milk allergy between January 2020 and July 2023. The consumption group underwent oral food challenges with baked egg or milk, and was instructed to include baked eggs and milk in their diet for at least 6 months. The control group, matched for age and specific IgE (sIgE) levels, restricted these foods. We compared the age at which tolerance was achieved, and analyzed changes in total IgE and sIgE levels against egg white (EW), ovomucoid (OM), and cow's milk (CM) in both groups. Results: Data were collected from 24 children in both the consumption and control groups. The consumption group demonstrated a significantly earlier acquisition of tolerance to egg and milk allergies compared to the control group (median: 24 vs. 31 months, P= 0.045). In the consumption group, total IgE and CM-sIgE levels showed no significant changes (P= 0.073 and P= 0.118, respectively), while EW- and OM-sIgE levels significantly decreased (P< 0.001 and P= 0.016, respectively). In the control group, total IgE and CM-sIgE levels significantly increased from baseline (P= 0.038 and P< 0.001, respectively), whereas there were no significant changes in EW- and OM-sIgE levels (P= 0.054 and P= 0.190, respectively). Between the consumption and control groups, no significant differences were observed in the changes in total IgE or specific IgE to EW, OM, and CM before and after the observation period (P= 0.404, P= 0.238, P= 0.531, and P= 0.167, respectively). Conclusion: These findings suggest that diets of baked eggs and milk may accelerate the development of tolerance in children with egg or milk allergies.

키워드

과제정보

This work was supported by the Yangyoung Foundation and by a National Research Foundation of Korea (NRF) grant funded by the Korean government (Ministry of Science and ICT) (2023R1A2C1002740).

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