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Multifaceted roles of trained immunity in diverse pathological contexts

  • Hyo Jin Park (Department of Biomedical Sciences, Graduate School of Medical Science, Brain Korea 21 Project, Gangnam Severance Hospital, Yonsei University College of Medicine) ;
  • Su Min Kim (Department of Biomedical Sciences, Graduate School of Medical Science, Brain Korea 21 Project, Gangnam Severance Hospital, Yonsei University College of Medicine) ;
  • Un Yung Choi (Department of Microbiology, Konkuk University School of Medicine) ;
  • Lark Kyun Kim (Department of Biomedical Sciences, Graduate School of Medical Science, Brain Korea 21 Project, Gangnam Severance Hospital, Yonsei University College of Medicine)
  • Received : 2024.03.20
  • Accepted : 2024.05.13
  • Published : 2024.10.31
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Abstract

Trained immunity, an innate immune response characterized by enhanced cellular responsiveness, exhibits a profound memory akin to adaptive immunity. This phenomenon involves intricate metabolic and epigenetic reprogramming triggered by stimuli such as β-glucan and BCG, shaping innate immune memory. Following elucidation of the background on trained immunity, it is important to explore its multifaceted roles in various pathological contexts. In this review, we delve into the specific contributions of trained immunity in the intricate landscape of viral infections, tumorigenesis, and diverse inflammatory diseases, shedding light on its potential as a therapeutic target, and offering comprehensive understanding of its broader immunological implications.

Keywords

Acknowledgement

This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (Ministry of Science and ICT, MSIT) (NRF-2023R1A2C1005804, and NRF-2022M3A9B6017424 to L.K.K. RS-2023-00245958 to U.Y.C.). Support was also provided by a grant from the MD-PhD/Medical Scientist Training Program, administered by the Korea Health Industry Development Institute (KHIDI) and funded by the Ministry of Health & Welfare of the Republic of Korea (S.M.K.).

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