Journal of radiological science and technology (대한방사선기술학회지:방사선기술과학)

Korean Society of Radiological Science (대한방사선과학회)
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Radiation Protection and Recovery Effects of Red Ginseng, Saururus chinensis (Lour.) Baill. and Rubus coreanus Miq. Mixed Extracts in SD Rat irradiated to Gamma-ray 6 Gy

감마선 6 Gy에 조사된 SD Rat에서 홍삼, 삼백초, 복분자 혼합 추출물의 방사선 방호 및 회복 효과

  • Seong-Ock Jin (Department of Emergency and Disaster Management, Inje University) ;
  • Jae-Hyeong Park (Department of Emergency and Disaster Management, Inje University) ;
  • Sung-Hyun Joo (Department of Radiation Convergence Chemistry, Inje University) ;
  • Jae-Gyeong Choi (Department of Radiation Convergence Chemistry, Inje University) ;
  • Byung-In Min (Department of Radiation Chemistry, Inje University)
  • 진성옥 (인제대학교 재난관리학과) ;
  • 박재형 (인제대학교 재난관리학과) ;
  • 주성현 (인제대학교 방사선융합화학과) ;
  • 최제경 (인제대학교 방사선융합화학과) ;
  • 민병인 (인제대학교 방사선화학과)
  • Received : 2024.06.17
  • Accepted : 2024.09.13
  • Published : 2024.10.31
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Abstract

The purpose of this study is to confirm the radiation protection and recovery effects of natural mixed radiation protection agents. Red Ginseng, Saururus chinensis (Lour.) Baill. and Rubus coreanus Miq. mixed extract was orally administered to male SD rats and changes were observed in the blood, small intestine and prostate. The experimental group was organized into a general control group (NC Group), mixed extract administration group (RSR Group), 6 Gy irradiation group (IR Group), and irradiation group after administration of the mixed extract (RSR+IR Group). Among them, the RSR Group and RSR+IR Group were orally administered 2 cc (36.6 mg/day/250 g) of the extract once for two weeks at the same time, and at the end of administration, the IR Group and RSR+IR Group were irradiated with 6 Gy whole body radiation. Looking at hematological changes, the RSR + IR Group showed higher recovery and higher levels of white blood cells and platelets than the IR Group. And SOD levels showed high activity in the group administered the extract. Looking at the small intestine, compared to the IR Group, the RSR+IR Group shows better protection and recovery of small intestine villi length. Likewise, in the prostate, there is less cell damage in the RSR+IR Group, and on the 21st day, the prostate spacing is constant, showing a similar pattern to the NC Group. It is believed that the mixed extract used in the study has radiation protection and recovery effects in male SD rats and will be helpful in the study of mixed radiation protection agents.

Keywords

Acknowledgement

This work was supported by the 2023 Inje University research grant.

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