해양환경안전학회지 (Journal of the Korean Society of Marine Environment & Safety)

  • 제30권5호
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  • Pages.387-395
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  • 2024
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  • 1229-3431(pISSN)
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  • 2287-3341(eISSN)
해양환경안전학회 (The Korean Society of Marine Environment and safety)
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해양 방사능 오염에 대비한 엽산과 토코페롤 혼합물의 방사선 방호효과에 관한 연구

A Study on Radioprotective Effects of Folic Acid and α-Tocopherol Mixture against Marine Radioactive Contamination

  • 신지혜 (한국해양과학기술원 해양환경연구부 ) ;
  • 민병인 (인제대학교 의생명보건대학 방사선학과)
  • Ji-Hye Shin (Marine Environment Research Department, Korea Institute of Ocean Science and Technology (KIOST)) ;
  • Byung-In Min (Department of Radiological Science, Inje University)
  • 투고 : 2024.07.19
  • 심사 : 2024.08.29
  • 발행 : 2024.08.31
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초록

2011년 일본 후쿠시마 원자력발전소 사고로 인해 130만 톤 이상의 방사능 오염수가 발생하였고, 2023년부터 일본 정부는 다량의 오염수를 바다로 방류하고 있다. 이 사고는 해양방사능 오염에 대한 우려와 해산물 섭취에 대한 불안감을 증가시켰으며, 특히 수산물 소비량이 높은 우리나라에서 방사선감수성이 높은 어린이와 태아에게 미치는 영향에 대한 걱정 등을 야기시켰다. 이러한 해양 방사능 오염 사태를 포함한 다양한 해양 방사능 누출 사고에 대비하기 위해 방사선 방호물질에 대한 연구의 필요성이 증대되고 있다. 천연 방사선방호제는 화학적 방사선방호제에 비해 부작용이 적고 상용화가 용이하다. 따라서 본 연구는 천연 항산화물질인 엽산과 α-토코페롤 혼합물이 방사선으로부터 생체를 보호하는 기능을 확인하고자 하였다. 실험은 방사선감수성이 높은 태아를 대상으로 하기 위하여 Spraque-Dawley rat (SD rat)을 사용하여 임신을 유도하였으며, 출산 후 2세대의 골격계, 혈액분석, 체중, 비장, 뇌 및 소장을 관찰하였다. 혈액분석과 소장의 융모길이, 대뇌피질 두께 측정에서 혼합물 투여 후 방사선조사군이 비교군(방사선조사군)에 비해 유의미한 회복(p<0.05)을 보였으며, 이는 엽산과 α-토코페롤 혼합물이 해양 방사능 오염 환경에서 생체 내 방사선방호에 효과적임을 시사한다.

In 2011, the Fukushima nuclear power plant accident in Japan resulted in more than 1.3 million tons of radioactive contaminated water, and the Japanese government has been releasing large amounts of contaminated water into the ocean since 2023. This accident has raised concerns about marine pollution and seafood consumption, as well as the effects on highly radiosensitive children and fetuses. Radiation protection materials are being researched to better prepare for various radiation accidents, including marine radioactive contamination incidents. Natural radioprotectors have fewer side effects and are more easily commercialized than chemical radioprotectors. This study aimed to confirm the function of a mixture of folic acid and α-tocopherol, natural antioxidants, in protecting living organisms from radiation. In the experiment, Spraque-Dawley rats (SD rats) were used to induce pregnancy to target fetuses with high radiation sensitivity, and the second generation's skeletal system, blood analysis, body weight, spleen, brain, and small intestine were examined after birth. After administering a mixture of folic acid and α-tocopherol, the irradiated group showed significant recovery (p<0.05) in blood analysis, small intestinal villus length, and cerebral cortex thickness measurements compared to the comparison group (irradiated group), suggesting that the mixture of folic acid and α-tocopherol is effective for in vivo radioprotection in a radioactive contaminated environment.

키워드

과제정보

본 연구논문은 한국해양과학기술원(KIOST)의 기관목적사업 "한반도 주변해의 해양환경/생태계 변동성 분석 및 진단 역량 강화(방사능분야)"(PEA0202)의 연구비 지원을 받아 작성되었습니다.

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