Biomedical Science Letters (대한의생명과학회지)

The Korean Society for Biomedical Laboratory Sciences (대한의생명과학회)
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Prevalence of Carbapenem-Resistant Enterobacterales and Their Diverse Resistance Mechanisms

  • Sohyeong Kim (Department of Clinical Laboratory Science, College of Health Sciences, Catholic University of Pusan) ;
  • Sang Rae Kim (Department of Clinical Laboratory Science, College of Health Sciences, Catholic University of Pusan) ;
  • Xianglan Xuan (Department of Clinical Laboratory Science, College of Health Sciences, Catholic University of Pusan) ;
  • Yujin Park (Department of Clinical Laboratory Science, College of Health Sciences, Catholic University of Pusan) ;
  • Seung Jun Roh (Department of Clinical Laboratory Science, College of Health Sciences, Catholic University of Pusan) ;
  • Sunghyun Kim (Department of Clinical Laboratory Science, College of Health Sciences, Catholic University of Pusan)
  • Received : 2024.05.31
  • Accepted : 2024.06.24
  • Published : 2024.09.30
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Abstract

This review provides an overview of carbapenem-resistant Enterobacterales (CRE) studies. CRE, called superbugs, has a high mortality rate and an increased resistance rate in several countries. The bacteria representing CRE are Klebsiella species and Escherichia spp., and they cause urinary tract infections (UTIs) and bloodstream infections (BSIs). CRE acquires resistance due to several mechanisms, typically divided into carbapenemase-producing (CP)-CRE and non-CP-CRE. Furthermore, although there are several antibiotics developed to treat CRE, they have their limitations; thus, antibiotic combination therapies or novel treatments are being developed. Therefore, since research on CRE and the use of appropriate antibiotics is important, some CRE-resistant mechanisms that enhance them are discussed. This review article was written using information obtained from Google Scholar and the National Center for Biotechnology Information website.

Keywords

Acknowledgement

This paper was supported by a research fund from the Catholic University of Pusan and by the BB21plus fund by Busan Metropolitan City and Busan Techno Park.

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