Journal of the Korean Applied Science and Technology (한국응용과학기술학회지)

The Korean Society of Applied Science and Technology (한국응용과학기술학회)
권호 표지
DOI QR코드

DOI QR Code

Analysis of Research Trends in the Skin Microbiome

피부 마이크로바이옴의 연구 동향 분석

  • Hyo-Jeong Son (Department of Medical Beauty at Yuhan University) ;
  • Seon-Hee You (Department of Global Medical Beauty at Konyang University)
  • 손효정 (유한대학교 의료뷰티학과) ;
  • 유선희 (건양대학교 글로벌의료뷰티학과)
  • Received : 2024.05.25
  • Accepted : 2024.06.21
  • Published : 2024.06.30
Download PDF
⟨ Previous Next ⟩

Abstract

On the skin, the microbiome, which includes bacteria, viruses, and fungi, coexist with human cells. Microbiome cosmetics are being developed actively in the field of skin and cosmetics recently. The skin microbiome is very diverse, and although the composition ratio and habitat are different, it nourishes the skin or restricts the proliferation of pathogens, which are competitors, through interactions in various ways. However, if the balance is broken, it can contribute to the destruction of immune homeostasis and lead to the development of skin diseases. Accordingly, this paper can be used as important data for the skin microbiome market, which has great future growth potential, by understanding the role and research trends of the skin microbiome, which is a symbiotic relationship with our skin, and by examining industrial trends in biological materials that help the microbiome balance.

피부에는 박테리아, 바이러스, 곰팡이를 포함하는 마이크로바이옴이 인체세포와 공존하고 있으며, 최근 피부 및 화장품 분야에서 피부 미생물 구성물과 피부 건강, 질병과의 연관성에 대해 많은 연구가 이루어지고 있을 뿐만 아니라 마이크로바이옴 화장품의 개발이 활발한 상황이다. 피부 마이크로바이옴은 매우 다양하며, 피부에서 구성비나 서식하는 부분이 다르지만 다양한 방법으로 상호작용을 통해 피부의 영양을 공급하거나 경쟁자인 병원균의 증식을 제한하고 있지만, 피부 마이크로바이옴과 병원균의 균형이 깨지면 면역 항상성의 파괴에 기여하고 피부 질환의 발병으로 이어질 수 있다. 이에 따라 본 논문은 우리 피부에 공생관계인 피부 마이크로바이옴의 역할과 연구 동향에 대해 파악하고, 마이크로바이옴 균형에 도움이 되는 바이오틱스 소재에 관한 산업동향을 고찰함으로써 미래의 큰 성장 가능성을 가진 피부 마이크로바이옴 시장의 중요한 자료로 사용될 수 있을 것으로 사료된다.

Keywords

References

  1. B. Y. Kim, "Microbiome research and industrial use", The Korean Society for Biotechnology and Bioengineering news, Vol.25, No.2 pp. 17-23, (2018). 
  2. K. A. Jang, Y. J. Hwang, H. R. Kim, K. O. Kim, Y. J. Lee, K. A. Hwang, "Research Trends in Microbiome Response to Diet Focused on Obesity", Food Industry and Nutrition, Vol.26, No.1 pp. 15-19, (2021). 
  3. M. S. Kim, D. G Lee, M. J. Kim, S. H. Kang, "The Role and Research Trends of Skin Microbiome Improving Skin Condition", Journal of Skin Barrier Research, Vol.23, No.2 pp. 41-42, (2021). 
  4. M. S. Shin, Y. K. Lee, S. Y. Choi, J. S. Hwang, P. Y. Song, H. C. Park, K. K. Kim, H. J. Son, Y. J. Kim, K. M. Lee, "Protective Effects of Trifolium pratense L. Extract against H2O2-induced Oxidative Stress in HaCaT Keratinocytes", Journal of the Korean Applied Science and Technology, Vol.40, No.2 pp. 223-232, (2023).  https://doi.org/10.12925/JKOCS.2023.40.2.223
  5. S. Y. Jeong, "Skin Microbiome for Cosmetic Application", Journal of Skin Barrier Research, Vol.21, No.1 pp. 30-34, (2019). 
  6. A. M. Lee, "Forensic application of Korean skin microbiome analysis", Unpublished master's dissertation, Sung Kyun Kwan University, Seoul, (2023). 
  7. Y. Belkaid, J. A. Segre, "Dialogue between skin microbiota and immunity", Science, Vol.346, No.6212 pp. 954-959, (2014).  https://doi.org/10.1126/science.1260144
  8. E. A. Grice, H. H. Kong, S. Conlan, C. B. Deming, J. Davis, A. C. Young, G. G. Bouffard, R. W. Blakesley, P. R. Murray, E. D. Green, "Topographical and temporal diversity of the human skin microbiome", Science, Vol.324, No.5931 pp. 1190-1192, (2009).  https://doi.org/10.1126/science.1171700
  9. E. A. Grice, J. A. Segre, "The skin microbiome", Nature reviews microbiology, Vol.9, No.4 pp. 244-253, (2011).  https://doi.org/10.1038/nrmicro2537
  10. J. H. Kim, J. S. Whang, "Skin Microbiome-Based Cosmetics and Therapeutics Industry Trends", bio economy brief. Vol.97 (2020). 
  11. S. S. Hur, "Development of Fermentation Process of Ginseng Leaf Extraction Probiotic Strain and Characterization of Product Quality", Journal of Oil & Applied Science, Vol.35, No.4 pp. 1213-1234, (2018). 
  12. Y. A. Lee, "Skin microbiome research trends", BRIC View, T03 (2023). 
  13. A. L. Byrd, Y. Belkaid, J. A. Segre., "The human skin microbiome", Nature Reviews Microbiology, Vol.16 pp. 143-155, (2018).  https://doi.org/10.1038/nrmicro.2017.157
  14. I. J. McLoughlin, E. M. Wrigh, J. R. Tagg, R. Jain, J. D. F. Hale, "Skin Microbiome-The Next Frontier for Probiotic Intervention", Probiotics Antimicrobial Proteins, Vol.14 pp. 630-647, (2022).  https://doi.org/10.1007/s12602-021-09824-1
  15. R. L Gallo, "Human Skin Is the Largest Epithelial Surface for Interaction with Microbes", Journal of Investigative Dermatology, Vol.137 pp. 1213-1214, (2017).  https://doi.org/10.1016/j.jid.2016.11.045
  16. H. H. Kong, J. A. Segre, "Biogeography and individuality shape function in the human skin metagenome", Nature, Vol.514, No.7520 pp. 59-64, (2014).  https://doi.org/10.1038/nature13786
  17. K. Findley, "Topographic diversity of fungal and bacterial communities in human skin", Nature, Vol.498 pp. 367-370, (2013).  https://doi.org/10.1038/nature12171
  18. K. T. Arnaud, K. Dorothee, S. Birgit, P. Andreas, "The epidermal lipid barrier in microbiome-skin interaction", Trends in Microbiology, Vol.7 pp. 723-734, (2023).  https://doi.org/10.1016/j.tim.2023.01.009
  19. Y. Lai, A. Di Nardo, T. Nakatsuji, A. Leichtle, Y. Yang, A. L. Cogen, Z. R. Wu, L. V. Hooper, R. R. Schmidt, S. V. Aulock, "Commensal bacteria regulate Toll-like receptor 3-dependent inflammation after skin injury", Nature Medicine, Vol.15 pp. 1377-1382, (2009).  https://doi.org/10.1038/nm.2062
  20. Y. Belkaid, O. J. Harrison, "Homeostatic Immunity and the Microbiota", Immunity, Vol. 46 pp. 562-576, (2017).  https://doi.org/10.1016/j.immuni.2017.04.008
  21. A. Balato. S. Cacciapuoti, R. Di Caprio, C. Marasca, A. Masara, A. Raimondo, G. Fabbrocini, "Human Microbiome: Composition and Role in Inflammatory Skin Diseases", Archivum Immunologiae et Therapiae Experimentalis, Vol.67 pp. 1-18, (2019).  https://doi.org/10.1007/s00005-018-0528-4
  22. S. Bajagai, Yadav, "Probiotics in animal nutrition: production, impact and regulation", Food and Agriculture Organization, (2016). 
  23. G. G. Manuel, T. Marta, R. Miguel, J. Rosario, G. Pilar, S. Manuel, J. Z. Maria, O. Monica, G. Julio, D. Juan, "Antihypertensive effects of probiotics Lactobacillus strains in spontaneously hypertensive rats", Molecular nutrition & food research, Vol.59, No.11 pp. 2326-2336, (2015).  https://doi.org/10.1002/mnfr.201500290
  24. L. Yuying, D. Q. Tran, J. Marc Rhoads, "Probiotics in disease prevention and treatment", The Journal of Clinical Pharmacology, Vol.58 pp. S164-S179, (2018).  https://doi.org/10.1002/jcph.1121
  25. A. Ljungh, T. Wadstrom, "Lactic acid Bacteria as Probiotics", Current Issues in Intestinal Microbiology, Vol.7, No.2 pp. 73-90, (2006). 
  26. S. J. Hong, M. S. Chong, S. H. Ahn, "A Review on Effects of Probiotics in Atopic Dermatitis", The Journal of Korean Oriental Ophthalmology & Otorhinolaryngology & Dermatology, Vol.33, No.1 pp. 25-44, (2020). 
  27. C. S. Wu, W. H. Chuo, Y. H. Chen, Y. H. Chao, C. C. Lin, Y. R. Li, W. H. Tsai, Y. K. Chen, "Lactobacillus pentosus GMNL-77 inhibits skin lesions in imiquimod-induced psoriasis-like mice", Journal of Dermatological Science, Vol.86, No.2 pp. 17-18, (2017).  https://doi.org/10.1016/j.jdermsci.2017.02.050
  28. K. F. Azman, R. Zakaria, "D-Galactose-induced accelerated aging model: an overview", Biogerontology, Vol.20, No.6 pp. 763-782, (2019).  https://doi.org/10.1007/s10522-019-09837-y
  29. K. M. Kim, H. Y. Kim, S. Y. Cha, Y. H Kim, J. W. Song, S. H. Lee, "Skin Barrier-enhancing, Antiwrinkle, and Antimelanogenic Effects of Probiotic Lysates Composed of Nucleotides", Journal of Korean Beauty Society, Vol.27, No.6 pp. 1343-1350, (2021).  https://doi.org/10.52660/JKSC.2021.27.6.1343
  30. V. P. Mariana, K. Lizardo, Freni, Tavaria, "Chapter 19 - Probiotics and skin health, Editor(s): Adriano Brandelli", Probiotics, Academic Press, pp. 389-405, (2022). 
  31. H. A. Hyun, D. H. Choi, H. S. Eom, J. S. Kim, E. T. Oh, J. Y. Cho, "Effects of 8 weeks Pregnancy Pilates Exercise and Probiotics Combined Treatment on Postnatal Women's Gut-microbiota, Body Composition, Blood Lipids, Obesity Hormones, Inflammatory Indicators", Journal of the Korean Applied Science and Technology, Vol.37, No.4 pp. 878-892, (2020).  https://doi.org/10.12925/JKOCS.2020.37.4.878
  32. F. H. AI-Ghazzewi, R. F. Tester, "Impact of prebiotics and probiotics on skin health", Beneficial microbes, Vol.5, No.2 pp. 99-107, (2014).  https://doi.org/10.3920/BM2013.0040
  33. R. G. Kerry, J. K. Patra, S. Gouda, Y. H. Park, H. S. Shin, G. Das, "Benefaction of probiotics for human health: A review", Journal of Food and Drug Analysis, Vol.26, No.3 pp. 927-939, (2018).  https://doi.org/10.1016/j.jfda.2018.01.002
  34. H. J. Pung, "A Study on the Stability, Human Skin Safety and Efficacy of Cleanser Containing Microbiome-related Complex", Unpublished master's dissertation, Ajou University, (2023). 
  35. R. M. Patel, P. W. Denning, "Therapeutic use of prebiotics, probiotics, and postbiotics to prevent necrotizing enterocolitis: what is the current evidence?", Clinics in perinatology, Vol.40, No.1 pp. 11-25, (2013).  https://doi.org/10.1016/j.clp.2012.12.002
  36. P. V. Panchamvedi, A. Patil, M. Monica Autiero, S. Mishra, T. Petry, "Cosmetic products containing human skin microbiome modulating ingredients - A safety assessment approach", Toxicology Letters, Vol. 384, No.1 pp. 24-40, (2023).  https://doi.org/10.1016/S0378-4274(23)00922-0
  37. D. Collins, Y. Qu, N. Huang, R. Cao, N. Pernodet, "437 Postbiotics power in supporting skin", Journal of Investigative Dermatology, Vol.142, No.8 Supplement, (2022). 
  38. A. Wasilewski, M. Zielinska, M. Storr, J. Fichna, "Beneficial Effects of Probiotics, Prebiotics, Synbiotics, and Psychobiotic in Inflammatory Bowel Disease", Inflammatory bowel disease, Vol.21, pp. 1674-1682, (2015).  https://doi.org/10.1097/MIB.0000000000000364
  39. Y. H. Kim, "Probiotics, prebiotics, Synbiotics and Human Health", BT NEWS, Vol.23, No.1 pp. 17-22, (2016). 
  40. K. Kaur, G. Rath, "Formulation and evaluation of UV protective synbiotic skin care topical formulation", Journal of Cosmetic and Laser Therapy, Vol.21, No.6 pp. 332-342, (2019).  https://doi.org/10.1080/14764172.2019.1658878
  41. M. Noll, M. Jager, L. Lux, C. Buettner, M. Axt-Gadermann, "Improvement of Atopic Dermatitis by Synbiotic Baths", Microorganisms, Vol.9, No.3 pp. 527, (2021). 
  42. ALCIMED. Skin Microbiome-The Development of a Science that will Transform the Cosmetic Industry, ALCIMED: Paris, France, (2016). 
  43. Korea Cosmetic Association. "Cosmetic Repot" Vol.265 May, (2021). 
  44. The brainy insights. "Microbiome Cosmetic Products Market Size by Type (Prebiotics, Postbiotics and Probiotics), Application (Serum, Creams & Moisturizer, Toner, Oil, Mist, and Others), Distribution Channel (Specialty Stores, Exclusive brand store, Hypermarket/supermarket, Online, and Others)" Regions, Global Industry Analysis, Share, Growth, Trends, and Forecast 2022 to 2030, (2022). 
  45. A. Bouslimani, R. D. Silva, T. Kosciolek, "The impact of skin care products on skin chemistry and microbiome dynamics", BMC Biology, Vol.17 pp. 1-20, (2019). https://doi.org/10.1186/s12915-018-0614-4