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The beneficial potential of ginseng for menopause

  • JiHyeon Song (Department of Integrative Bioscience and Biotechnology, College of Life Science, Sejong University) ;
  • Namkyu Lee (Department of Integrative Bioscience and Biotechnology, College of Life Science, Sejong University) ;
  • Hyun-Jeong Yang (Department of Integrative Healthcare, University of Brain Education) ;
  • Myeong Soo Lee (KM Science Research Division, Korea Institute of Oriental Medicine) ;
  • Spandana Rajendra Kopalli (Department of Integrative Bioscience and Biotechnology, College of Life Science, Sejong University) ;
  • Yong-ung Kim (Department of Pharmaceutical Engineering, College of Cosmetics and Pharmaceuticals, Daegu Haany University) ;
  • YoungJoo Lee (Department of Integrative Bioscience and Biotechnology, College of Life Science, Sejong University)
  • Received : 2023.10.31
  • Accepted : 2024.05.30
  • Published : 2024.09.01

Abstract

Korean Red Ginseng (KRG) has long been used not only as a food supplement but also as a treatment for various diseases. Ginseng originated in South Korea, which later spread to China and Japan, has a wide range of pharmacological activities including immune, endocrine, cardiovascular, and central nervous system effects. KRG is produced by repetitions of steaming and drying of ginseng to extend preservation. During this steaming process, the components of ginseng undergo physio-chemical changes forming a variety of potential active constituents including ginsenoside-Rg3, a unique compound in KRG. Pandemic Coronavirus disease 2019 (COVID-19), has affected both men and women differentially. In particular, women were more vulnerable to COVID-related distress which in turn could aggravate menopause-related disturbances. Complementary and alternative medicinal plants could have aided middle-aged women for several menopause-related symptoms during and post COVID-19 pandemic. This review aimed to explore the beneficial effects of KRG on menopausal symptoms and gynecological cancer.

Keywords

Acknowledgement

This research was supported 2022 grant from the Korean Society of Ginseng to YJL and by Korea Ministry of Environment (MOE) as Graduate School specialized in Climate Change.

References

  1. Irfan M, et al. Adaptogenic effects of Panax ginseng on modulation of cardiovascular functions. J Ginseng Res 2020;44(4):538-43.
  2. Yoon SJ, et al. Effect of Korean red ginseng on metabolic syndrome. J Ginseng Res 2021;45(3):380-9.
  3. Irfan M, Kim M, Rhee MH. Anti-platelet role of Korean ginseng and ginsenosides in cardiovascular diseases. J Ginseng Res 2020;44(1):24-32.
  4. Hyun SH, et al. Effects of Panax ginseng and ginsenosides on oxidative stress and cardiovascular diseases: pharmacological and therapeutic roles. J Ginseng Res 2022;46(1):33-8.
  5. Lee J, et al. Comparative transcriptome analysis of the protective effects of Korean Red Ginseng against the influence of bisphenol A in the liver and uterus of ovariectomized mice. J Ginseng Res 2020;44(3):519-26.
  6. Park J, et al. The effect of Korean red ginseng on bisphenol A-induced fatty acid composition and lipid metabolism-related gene expression changes. Am J Chin Med 2020;48(8):1841-58.
  7. Lee J. Dong-Yi-Soo-Se-Bo-Won. Seoul, Korea: Je Ma Lee; 1894.
  8. Lee S-W, et al. A clinical study on the Sasang constitutional preference for foods. Korean Journal of Oriental Medicine 2007;13(1):77-83.
  9. Hwang SK, et al. Rg3-enriched red ginseng extract promotes lung cancer cell apoptosis and mitophagy by ROS production. J Ginseng Res 2022;46(1):138-46.
  10. Huang WC, et al. Ginsenoside Rg3 ameliorates allergic airway inflammation and oxidative stress in mice. J Ginseng Res 2021;45(6):654-64.
  11. He S, et al. Anti-tumor activities of Panax quinquefolius saponins and potential biomarkers in prostate cancer. J Ginseng Res 2021;45(2):273-86.
  12. Song H, et al. Korean Red Ginseng suppresses bisphenol A-induced expression of cyclooxygenase-2 and cellular migration of A549 human lung cancer cell through inhibition of reactive oxygen species. J Ginseng Res 2021;45(1):119-25.
  13. Park J, et al. Effects of ginseng on two main sex steroid hormone receptors: estrogen and androgen receptors. J Ginseng Res 2017;41(2):215-21.
  14. Chen CF, Chiou WF, Zhang JT. Comparison of the pharmacological effects of Panax ginseng and Panax quinquefolium. Acta Pharmacol Sin 2008;29(9):1103-8.
  15. Lee SM, et al. Characterization of Korean red ginseng (Panax ginseng meyer): history, preparation method, and chemical composition. J Ginseng Res 2015;39(4):384-91.
  16. In G, et al. In situ analysis of chemical components induced by steaming between fresh ginseng, steamed ginseng, and red ginseng. J Ginseng Res 2017;41(3):361-9.
  17. Jovanovski E, et al. Effect of coadministration of enriched Korean Red Ginseng (Panax ginseng) and American ginseng (Panax quinquefolius L) on cardiometabolic outcomes in type-2 diabetes: a randomized controlled trial. J Ginseng Res 2021;45(5):546-54.
  18. Hyun SH, et al. Physiological and pharmacological features of the non-saponin components in Korean Red Ginseng. J Ginseng Res 2020;44(4):527-37.
  19. Cheng H, et al. Comparative studies of the antiproliferative effects of ginseng polysaccharides on HT-29 human colon cancer cells. Med Oncol 2011;28(1):175-81.
  20. Reyes AW, et al. Inhibitory effect of red ginseng acidic polysaccharide from Korean red ginseng on phagocytic activity and intracellular replication of Brucella abortus in RAW 264.7 cells. J Vet Sci 2016;17(3):315-21.
  21. Kwak YS, et al. Anti-hyperlipidemic effects of red ginseng acidic polysaccharide from Korean red ginseng. Biol Pharm Bull 2010;33(3):468-72.
  22. Byeon SE, et al. Molecular mechanism of macrophage activation by red ginseng acidic polysaccharide from Korean red ginseng. Mediat Inflamm 2012;2012:732860.
  23. Li B, et al. The core structure characterization and of ginseng neutral polysaccharide with the immune-enhancing activity. Int J Biol Macromol 2019;123:713-22.
  24. Park DH, et al. Enhanced intestinal immune response in mice after oral administration of Korea red ginseng-derived polysaccharide. Polymers 2020;12(10).
  25. Notification, M.o.F.a.D.S. Ministry of food and drug safety of the Republic of Korea: health functional food code, 12/21; 2016.
  26. Liu N, et al. Prevalence and predictors of PTSS during COVID-19 outbreak in China hardest-hit areas: gender differences matter. Psychiatr Res 2020;287:112921.
  27. Song J, Lee Y. Protective role of ginseng in endometriosis during covid-19. J Ginseng Res 2023;47(2):169-72.
  28. Chen J, et al. Individual variation of the SARS-CoV-2 receptor ACE2 gene expression and regulation. Aging Cell 2020;19(7).
  29. Balcazar-Hernandez L, et al. Women and COVID-19: severity and mortality in hospitalized middle-aged and older patients. Climacteric 2021;24(3):313-5.
  30. Tode T, et al. Effect of Korean red ginseng on psychological functions in patients with severe climacteric syndromes. Int J Gynecol Obstet 1999;67(3):169-74.
  31. Ogita S. Clinical application of Korean red ginseng in gynecological diseases. Ginseng Rev 1988;6:363-70.
  32. Chung TH, et al. The effects of Korean red ginseng on biological aging and antioxidant capacity in postmenopausal women: a double-blind randomized controlled study. Nutrients 2021;13(9).
  33. Oh K-J, et al. Effects of Korean red ginseng on sexual arousal in menopausal women: placebo-controlled, double-blind crossover clinical study. J Sex Med 2010;7(4):1469-77.
  34. Lee HW, Ang L, Lee MS. Using ginseng for menopausal women's health care: a systematic review of randomized placebo-controlled trials. Compl Ther Clin Pract 2022;48:101615.
  35. Cho A, et al. Protective effects of red ginseng extract against vaginal herpes simplex virus infection. J Ginseng Res 2013;37(2):210-8.
  36. Cho M, et al. Enhanced Rg3 negatively regulates Th1 cell responses. J Ginseng Res 2019;43(1):49-57.
  37. Im K, Kim J, Min H. Ginseng, the natural effectual antiviral: protective effects of Korean Red Ginseng against viral infection. J Ginseng Res 2016;40(4):309-14.
  38. Ghorbani Z, et al. The effect of ginseng on sexual dysfunction in menopausal women: a double-blind, randomized, controlled trial. Compl Ther Med 2019;45:57-64.
  39. Song H, et al. Ginsenoside Rf inhibits cyclooxygenase-2 induction via peroxisome proliferator-activated receptor gamma in A549 cells. J Ginseng Res 2019;43(2):319-25.
  40. Yu S, et al. Effects of red ginseng on gut, microbiota, and brain in a mouse model of post-infectious irritable bowel syndrome. J Ginseng Res 2021;45(6):706-16.
  41. Seo SK, et al. Antioxidative effects of Korean red ginseng in postmenopausal women: a double-blind randomized controlled trial. J Ethnopharmacol 2014;154(3):753-7.
  42. Kim SY, et al. Effects of red ginseng supplementation on menopausal symptoms and cardiovascular risk factors in postmenopausal women: a double-blind randomized controlled trial. Menopause 2012;19(4):461-6.
  43. Kwon YJ, et al. Effect of Korean red ginseng on cholesterol metabolites in postmenopausal women with hypercholesterolemia: a pilot randomized controlled trial. Nutrients 2020;12(11).
  44. Shim MK, Lee YJ. Estrogen receptor is activated by Korean red ginseng in vitro but not in vivo. J Ginseng Res 2012;36(2):169-75.
  45. Lee H, et al. Effects of Korean red ginseng (Panax ginseng) on obesity and adipose inflammation in ovariectomized mice. J Ethnopharmacol 2016;178:229-37.
  46. Zhu D, Montagne A, Zhao Z. Alzheimer's pathogenic mechanisms and underlying sex difference. Cell Mol Life Sci 2021;78(11):4907-20.
  47. Rentz DM, et al. Sex differences in episodic memory in early midlife: impact of reproductive aging. Menopause 2017;24(4):400-8.
  48. Maki PM, Henderson VW. Cognition and the menopause transition. Menopause 2016;23(7):803-5.
  49. Greendale GA, et al. Menopause-associated symptoms and cognitive performance: results from the study of women's health across the nation. Am J Epidemiol 2010;171(11):1214-24.
  50. Namgung E, et al. Effects of Korean red ginseng on human gray matter volume and cognitive function: a voxel-based morphometry study. Hum Psychopharmacol 2021;36(2):e2767.
  51. Lho SK, et al. Effects of lifetime cumulative ginseng intake on cognitive function in late life. Alzheimer's Res Ther 2018;10(1):50.
  52. Lee BC, et al. Ginseng intake and Alzheimer disease-specific cognition in older adults according to apolipoprotein ε4 allele status. Front Aging Neurosci 2023;15:1152626.
  53. Baek JH, et al. Effect of Korean Red Ginseng in individuals exposed to high stress levels: a 6-week, double-blind, randomized, placebo-controlled trial. J Ginseng Res 2019;43(3):402-7.
  54. Mostafa RE, Shaffie NM, Allam RM. Panax Ginseng alleviates thioacetamide-induced liver injury in ovariectomized rats: crosstalk between inflammation and oxidative stress. PLoS One 2021;16(11):e0260507.
  55. Yamada N, Araki H, Yoshimura H. Identification of antidepressant-like ingredients in ginseng root (Panax ginseng C.A. Meyer) using a menopausal depressive-like state in female mice: participation of 5-HT2A receptors. Psychopharmacology (Berl) 2011;216(4):589-99.
  56. Hao K, et al. Beneficial estrogen-like effects of ginsenoside Rb1, an active component of Panax ginseng, on neural 5-HT disposition and behavioral tasks in ovariectomized mice. Eur J Pharmacol 2011;659(1):15-25.
  57. Zhang X, et al. Effects of ginsenoside Rg1 or 17β-estradiol on a cognitively impaired, ovariectomized rat model of Alzheimer's disease. Neuroscience 2012;220:191-200.
  58. Yang N, et al. Ginsenoside Rc promotes bone formation in ovariectomy-induced osteoporosis in vivo and osteogenic differentiation in vitro. Int J Mol Sci 2022;23(11).
  59. Zhang X, et al. Ginsenoside Rg3 attenuates ovariectomy-induced osteoporosis via AMPK/mTOR signaling pathway. Drug Dev Res 2020;81(7):875-84.
  60. Kim HS, et al. Effect of red ginseng on genotoxicity and health-related quality of life after adjuvant chemotherapy in patients with epithelial ovarian cancer: a randomized, double blind, placebo-controlled trial. Nutrients 2017;9(7).
  61. Chung YS, et al. Effects of Korean red ginseng (Panax ginseng C.A. Meyer) on menopausal symptoms in premenopausal women after gynecologic cancer surgery: a double-blind, randomized controlled trial. J Alternative Compl Med 2021;27(1):66-72.
  62. Hamidian M, et al. Protective effects of Panax ginseng against doxorubicin-induced cardiac toxicity in patients with non-metastatic breast cancer: a randomized, double-blind, placebo-controlled clinical trial. J Oncol Pharm Pract 2022:10781552221118530.
  63. Hamidian M, et al. Effects of Panax ginseng on health-related quality of life in patients with non-metastatic breast cancer: a randomized, double-blind, placebo-controlled clinical trial ginseng for HRQOL in breast cancer. Nutr Cancer 2023;75(6):1429-37.
  64. Shin W, et al. Korean red ginseng inhibits arginase and contributes to endotheliumdependent vasorelaxation through endothelial nitric oxide synthase coupling. J Ginseng Res 2013;37(1):64-73.
  65. Rhee MY, et al. Effect of Korean red ginseng on arterial stiffness in subjects with hypertension. J Alternative Compl Med 2011;17(1):45-9.
  66. Kim ND, Kang SY, Schini VB. Ginsenosides evoke endothelium-dependent vascular relaxation in rat aorta. Gen Pharmacol 1994;25(6):1071-7.
  67. Kang SY, Schini-Kerth VB, Kim ND. Ginsenosides of the protopanaxatriol group cause endothelium-dependent relaxation in the rat aorta. Life Sci 1995;56(19):1577-86.
  68. Chung CH, et al. Influence of total ginseng saponin on contractile responses of vasoconstrictors in the isolated rat aorta. Korean Circ J 1999;29(9):976-84.
  69. Lee N, et al. KRG and its major ginsenosides do not show distinct steroidogenic activities examined by the OECD test guideline 440 and 456 assays. J Ginseng Res 2023;47(3):385-9.
  70. Li J, et al. 20(S)-Rg3 blocked epithelial-mesenchymal transition through DNMT3A/miR-145/FSCN1 in ovarian cancer. Oncotarget 2017;8(32):53375-86.
  71. Kim R, et al. Cytotoxic properties of C(17) polyacetylenes from the fresh roots of Panax ginseng on human epithelial ovarian cancer cells. Molecules 2022;27(20).
  72. Duda RB, et al. American ginseng transcriptionally activates p21 mRNA in breast cancer cell lines. J Kor Med Sci 2001;16(Suppl):S54-60. Suppl.
  73. Liu Y, Fan D. Ginsenoside Rg5 induces apoptosis and autophagy via the inhibition of the PI3K/Akt pathway against breast cancer in a mouse model. Food Funct 2018;9(11):5513-27.
  74. Yagi T, et al. Safety and efficacy of Ninjin'yoeito along with iron supplementation therapy for preoperative anemia, fatigue, and anxiety in patients with gynecological disease: an open-label, single-center, randomized phase-II trial. BMC Wom Health 2022;22(1):229.
  75. Ogita S. Clinical effectiveness of Korea ginseng on climacteric bisturbances and its possible mechanism of action. Journal of Ginseng Research 1990;14(2):162-6.
  76. So SH, et al. Red ginseng monograph. J Ginseng Res 2018;42(4):549-61.
  77. Zhao TT, et al. Dietary isoflavones or isoflavone-rich food intake and breast cancer risk: a meta-analysis of prospective cohort studies. Clin Nutr 2019;38(1):136-45.
  78. Park JY, , et alPanax ginseng CA. Meyer alleviates benign prostatic hyperplasia while preventing finasteride-induced side effects. Front Pharmacol 2023;14:1039622.
  79. Kim M, et al. Function of Korean black ginseng: improvement of andropause symptoms by a complex extract of black ginseng and fenugreek in TM3 Leydig cells and aged rats. Journal of Ethnic Foods 2016;3(3):228-34.