Acknowledgement
This research was supported 2022 grant from the Korean Society of Ginseng to YJL and by Korea Ministry of Environment (MOE) as Graduate School specialized in Climate Change.
References
- Irfan M, et al. Adaptogenic effects of Panax ginseng on modulation of cardiovascular functions. J Ginseng Res 2020;44(4):538-43.
- Yoon SJ, et al. Effect of Korean red ginseng on metabolic syndrome. J Ginseng Res 2021;45(3):380-9.
- Irfan M, Kim M, Rhee MH. Anti-platelet role of Korean ginseng and ginsenosides in cardiovascular diseases. J Ginseng Res 2020;44(1):24-32.
- Hyun SH, et al. Effects of Panax ginseng and ginsenosides on oxidative stress and cardiovascular diseases: pharmacological and therapeutic roles. J Ginseng Res 2022;46(1):33-8.
- Lee J, et al. Comparative transcriptome analysis of the protective effects of Korean Red Ginseng against the influence of bisphenol A in the liver and uterus of ovariectomized mice. J Ginseng Res 2020;44(3):519-26.
- Park J, et al. The effect of Korean red ginseng on bisphenol A-induced fatty acid composition and lipid metabolism-related gene expression changes. Am J Chin Med 2020;48(8):1841-58.
- Lee J. Dong-Yi-Soo-Se-Bo-Won. Seoul, Korea: Je Ma Lee; 1894.
- Lee S-W, et al. A clinical study on the Sasang constitutional preference for foods. Korean Journal of Oriental Medicine 2007;13(1):77-83.
- Hwang SK, et al. Rg3-enriched red ginseng extract promotes lung cancer cell apoptosis and mitophagy by ROS production. J Ginseng Res 2022;46(1):138-46.
- Huang WC, et al. Ginsenoside Rg3 ameliorates allergic airway inflammation and oxidative stress in mice. J Ginseng Res 2021;45(6):654-64.
- He S, et al. Anti-tumor activities of Panax quinquefolius saponins and potential biomarkers in prostate cancer. J Ginseng Res 2021;45(2):273-86.
- Song H, et al. Korean Red Ginseng suppresses bisphenol A-induced expression of cyclooxygenase-2 and cellular migration of A549 human lung cancer cell through inhibition of reactive oxygen species. J Ginseng Res 2021;45(1):119-25.
- Park J, et al. Effects of ginseng on two main sex steroid hormone receptors: estrogen and androgen receptors. J Ginseng Res 2017;41(2):215-21.
- Chen CF, Chiou WF, Zhang JT. Comparison of the pharmacological effects of Panax ginseng and Panax quinquefolium. Acta Pharmacol Sin 2008;29(9):1103-8.
- Lee SM, et al. Characterization of Korean red ginseng (Panax ginseng meyer): history, preparation method, and chemical composition. J Ginseng Res 2015;39(4):384-91.
- In G, et al. In situ analysis of chemical components induced by steaming between fresh ginseng, steamed ginseng, and red ginseng. J Ginseng Res 2017;41(3):361-9.
- Jovanovski E, et al. Effect of coadministration of enriched Korean Red Ginseng (Panax ginseng) and American ginseng (Panax quinquefolius L) on cardiometabolic outcomes in type-2 diabetes: a randomized controlled trial. J Ginseng Res 2021;45(5):546-54.
- Hyun SH, et al. Physiological and pharmacological features of the non-saponin components in Korean Red Ginseng. J Ginseng Res 2020;44(4):527-37.
- Cheng H, et al. Comparative studies of the antiproliferative effects of ginseng polysaccharides on HT-29 human colon cancer cells. Med Oncol 2011;28(1):175-81.
- Reyes AW, et al. Inhibitory effect of red ginseng acidic polysaccharide from Korean red ginseng on phagocytic activity and intracellular replication of Brucella abortus in RAW 264.7 cells. J Vet Sci 2016;17(3):315-21.
- Kwak YS, et al. Anti-hyperlipidemic effects of red ginseng acidic polysaccharide from Korean red ginseng. Biol Pharm Bull 2010;33(3):468-72.
- Byeon SE, et al. Molecular mechanism of macrophage activation by red ginseng acidic polysaccharide from Korean red ginseng. Mediat Inflamm 2012;2012:732860.
- Li B, et al. The core structure characterization and of ginseng neutral polysaccharide with the immune-enhancing activity. Int J Biol Macromol 2019;123:713-22.
- Park DH, et al. Enhanced intestinal immune response in mice after oral administration of Korea red ginseng-derived polysaccharide. Polymers 2020;12(10).
- Notification, M.o.F.a.D.S. Ministry of food and drug safety of the Republic of Korea: health functional food code, 12/21; 2016.
- Liu N, et al. Prevalence and predictors of PTSS during COVID-19 outbreak in China hardest-hit areas: gender differences matter. Psychiatr Res 2020;287:112921.
- Song J, Lee Y. Protective role of ginseng in endometriosis during covid-19. J Ginseng Res 2023;47(2):169-72.
- Chen J, et al. Individual variation of the SARS-CoV-2 receptor ACE2 gene expression and regulation. Aging Cell 2020;19(7).
- Balcazar-Hernandez L, et al. Women and COVID-19: severity and mortality in hospitalized middle-aged and older patients. Climacteric 2021;24(3):313-5.
- Tode T, et al. Effect of Korean red ginseng on psychological functions in patients with severe climacteric syndromes. Int J Gynecol Obstet 1999;67(3):169-74.
- Ogita S. Clinical application of Korean red ginseng in gynecological diseases. Ginseng Rev 1988;6:363-70.
- Chung TH, et al. The effects of Korean red ginseng on biological aging and antioxidant capacity in postmenopausal women: a double-blind randomized controlled study. Nutrients 2021;13(9).
- Oh K-J, et al. Effects of Korean red ginseng on sexual arousal in menopausal women: placebo-controlled, double-blind crossover clinical study. J Sex Med 2010;7(4):1469-77.
- Lee HW, Ang L, Lee MS. Using ginseng for menopausal women's health care: a systematic review of randomized placebo-controlled trials. Compl Ther Clin Pract 2022;48:101615.
- Cho A, et al. Protective effects of red ginseng extract against vaginal herpes simplex virus infection. J Ginseng Res 2013;37(2):210-8.
- Cho M, et al. Enhanced Rg3 negatively regulates Th1 cell responses. J Ginseng Res 2019;43(1):49-57.
- Im K, Kim J, Min H. Ginseng, the natural effectual antiviral: protective effects of Korean Red Ginseng against viral infection. J Ginseng Res 2016;40(4):309-14.
- Ghorbani Z, et al. The effect of ginseng on sexual dysfunction in menopausal women: a double-blind, randomized, controlled trial. Compl Ther Med 2019;45:57-64.
- Song H, et al. Ginsenoside Rf inhibits cyclooxygenase-2 induction via peroxisome proliferator-activated receptor gamma in A549 cells. J Ginseng Res 2019;43(2):319-25.
- Yu S, et al. Effects of red ginseng on gut, microbiota, and brain in a mouse model of post-infectious irritable bowel syndrome. J Ginseng Res 2021;45(6):706-16.
- Seo SK, et al. Antioxidative effects of Korean red ginseng in postmenopausal women: a double-blind randomized controlled trial. J Ethnopharmacol 2014;154(3):753-7.
- Kim SY, et al. Effects of red ginseng supplementation on menopausal symptoms and cardiovascular risk factors in postmenopausal women: a double-blind randomized controlled trial. Menopause 2012;19(4):461-6.
- Kwon YJ, et al. Effect of Korean red ginseng on cholesterol metabolites in postmenopausal women with hypercholesterolemia: a pilot randomized controlled trial. Nutrients 2020;12(11).
- Shim MK, Lee YJ. Estrogen receptor is activated by Korean red ginseng in vitro but not in vivo. J Ginseng Res 2012;36(2):169-75.
- Lee H, et al. Effects of Korean red ginseng (Panax ginseng) on obesity and adipose inflammation in ovariectomized mice. J Ethnopharmacol 2016;178:229-37.
- Zhu D, Montagne A, Zhao Z. Alzheimer's pathogenic mechanisms and underlying sex difference. Cell Mol Life Sci 2021;78(11):4907-20.
- Rentz DM, et al. Sex differences in episodic memory in early midlife: impact of reproductive aging. Menopause 2017;24(4):400-8.
- Maki PM, Henderson VW. Cognition and the menopause transition. Menopause 2016;23(7):803-5.
- Greendale GA, et al. Menopause-associated symptoms and cognitive performance: results from the study of women's health across the nation. Am J Epidemiol 2010;171(11):1214-24.
- Namgung E, et al. Effects of Korean red ginseng on human gray matter volume and cognitive function: a voxel-based morphometry study. Hum Psychopharmacol 2021;36(2):e2767.
- Lho SK, et al. Effects of lifetime cumulative ginseng intake on cognitive function in late life. Alzheimer's Res Ther 2018;10(1):50.
- Lee BC, et al. Ginseng intake and Alzheimer disease-specific cognition in older adults according to apolipoprotein ε4 allele status. Front Aging Neurosci 2023;15:1152626.
- Baek JH, et al. Effect of Korean Red Ginseng in individuals exposed to high stress levels: a 6-week, double-blind, randomized, placebo-controlled trial. J Ginseng Res 2019;43(3):402-7.
- Mostafa RE, Shaffie NM, Allam RM. Panax Ginseng alleviates thioacetamide-induced liver injury in ovariectomized rats: crosstalk between inflammation and oxidative stress. PLoS One 2021;16(11):e0260507.
- Yamada N, Araki H, Yoshimura H. Identification of antidepressant-like ingredients in ginseng root (Panax ginseng C.A. Meyer) using a menopausal depressive-like state in female mice: participation of 5-HT2A receptors. Psychopharmacology (Berl) 2011;216(4):589-99.
- Hao K, et al. Beneficial estrogen-like effects of ginsenoside Rb1, an active component of Panax ginseng, on neural 5-HT disposition and behavioral tasks in ovariectomized mice. Eur J Pharmacol 2011;659(1):15-25.
- Zhang X, et al. Effects of ginsenoside Rg1 or 17β-estradiol on a cognitively impaired, ovariectomized rat model of Alzheimer's disease. Neuroscience 2012;220:191-200.
- Yang N, et al. Ginsenoside Rc promotes bone formation in ovariectomy-induced osteoporosis in vivo and osteogenic differentiation in vitro. Int J Mol Sci 2022;23(11).
- Zhang X, et al. Ginsenoside Rg3 attenuates ovariectomy-induced osteoporosis via AMPK/mTOR signaling pathway. Drug Dev Res 2020;81(7):875-84.
- Kim HS, et al. Effect of red ginseng on genotoxicity and health-related quality of life after adjuvant chemotherapy in patients with epithelial ovarian cancer: a randomized, double blind, placebo-controlled trial. Nutrients 2017;9(7).
- Chung YS, et al. Effects of Korean red ginseng (Panax ginseng C.A. Meyer) on menopausal symptoms in premenopausal women after gynecologic cancer surgery: a double-blind, randomized controlled trial. J Alternative Compl Med 2021;27(1):66-72.
- Hamidian M, et al. Protective effects of Panax ginseng against doxorubicin-induced cardiac toxicity in patients with non-metastatic breast cancer: a randomized, double-blind, placebo-controlled clinical trial. J Oncol Pharm Pract 2022:10781552221118530.
- Hamidian M, et al. Effects of Panax ginseng on health-related quality of life in patients with non-metastatic breast cancer: a randomized, double-blind, placebo-controlled clinical trial ginseng for HRQOL in breast cancer. Nutr Cancer 2023;75(6):1429-37.
- Shin W, et al. Korean red ginseng inhibits arginase and contributes to endotheliumdependent vasorelaxation through endothelial nitric oxide synthase coupling. J Ginseng Res 2013;37(1):64-73.
- Rhee MY, et al. Effect of Korean red ginseng on arterial stiffness in subjects with hypertension. J Alternative Compl Med 2011;17(1):45-9.
- Kim ND, Kang SY, Schini VB. Ginsenosides evoke endothelium-dependent vascular relaxation in rat aorta. Gen Pharmacol 1994;25(6):1071-7.
- Kang SY, Schini-Kerth VB, Kim ND. Ginsenosides of the protopanaxatriol group cause endothelium-dependent relaxation in the rat aorta. Life Sci 1995;56(19):1577-86.
- Chung CH, et al. Influence of total ginseng saponin on contractile responses of vasoconstrictors in the isolated rat aorta. Korean Circ J 1999;29(9):976-84.
- Lee N, et al. KRG and its major ginsenosides do not show distinct steroidogenic activities examined by the OECD test guideline 440 and 456 assays. J Ginseng Res 2023;47(3):385-9.
- Li J, et al. 20(S)-Rg3 blocked epithelial-mesenchymal transition through DNMT3A/miR-145/FSCN1 in ovarian cancer. Oncotarget 2017;8(32):53375-86.
- Kim R, et al. Cytotoxic properties of C(17) polyacetylenes from the fresh roots of Panax ginseng on human epithelial ovarian cancer cells. Molecules 2022;27(20).
- Duda RB, et al. American ginseng transcriptionally activates p21 mRNA in breast cancer cell lines. J Kor Med Sci 2001;16(Suppl):S54-60. Suppl.
- Liu Y, Fan D. Ginsenoside Rg5 induces apoptosis and autophagy via the inhibition of the PI3K/Akt pathway against breast cancer in a mouse model. Food Funct 2018;9(11):5513-27.
- Yagi T, et al. Safety and efficacy of Ninjin'yoeito along with iron supplementation therapy for preoperative anemia, fatigue, and anxiety in patients with gynecological disease: an open-label, single-center, randomized phase-II trial. BMC Wom Health 2022;22(1):229.
- Ogita S. Clinical effectiveness of Korea ginseng on climacteric bisturbances and its possible mechanism of action. Journal of Ginseng Research 1990;14(2):162-6.
- So SH, et al. Red ginseng monograph. J Ginseng Res 2018;42(4):549-61.
- Zhao TT, et al. Dietary isoflavones or isoflavone-rich food intake and breast cancer risk: a meta-analysis of prospective cohort studies. Clin Nutr 2019;38(1):136-45.
- Park JY, , et alPanax ginseng CA. Meyer alleviates benign prostatic hyperplasia while preventing finasteride-induced side effects. Front Pharmacol 2023;14:1039622.
- Kim M, et al. Function of Korean black ginseng: improvement of andropause symptoms by a complex extract of black ginseng and fenugreek in TM3 Leydig cells and aged rats. Journal of Ethnic Foods 2016;3(3):228-34.