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Mucin-Rich Brain Metastasis May Show the T2-FLAIR Mismatch Sign: A Case Report and Literature Review

T2-FLAIR Mismatch Sign을 나타내는 점액성 뇌전이암: 증례 보고 및 문헌 고찰

  • Hyun Jae Kim (Yonsei University College of Medicine) ;
  • Yoon Jin Cha (Department of Pathology, Gangnam Severance Hospital, Yonsei University College of Medicine) ;
  • Seung Ho Choi (Yonsei University College of Medicine) ;
  • Chang Joon Kang (Yonsei University College of Medicine) ;
  • Jihwan Yoo (Department of Neurosurgery, Brain Tumor Center, Gangnam Severance Hospital, Yonsei University College of Medicine) ;
  • Sung Jun Ahn (Department of Radiology, Gangnam Severance Hospital, Yonsei University College of Medicine)
  • 김현재 (연세대학교 의과대학) ;
  • 차윤진 (연세대학교 의과대학 강남세브란스병원 병리과) ;
  • 최승호 (연세대학교 의과대학) ;
  • 강창준 (연세대학교 의과대학) ;
  • 유지환 (연세대학교 의과대학 강남세브란스병원 뇌종양센터 신경외과) ;
  • 안성준 (연세대학교 의과대학 강남세브란스병원 영상의학과)
  • Received : 2023.10.27
  • Accepted : 2024.01.15
  • Published : 2024.07.01

Abstract

This study describes a unique case of single mucin-rich brain metastasis in a patient with breast cancer, mimicking the T2-fluid attenuation inversion recovery (FLAIR) mismatch sign and masquerading as an isocitrate dehydrogenase-mutant astrocytoma. This case highlights the importance of considering mucin-rich lesions in the differential diagnosis of intracranial tumors exhibiting T2-FLAIR mismatch. Clinicians must recognize the potential convergence in imaging characteristics between these metastases and gliomas to guarantee prompt and accurate patient care.

T2-fluid attenuation inversion recovery (이하 FLAIR) mismatch sign은 isocitrate dehydrogenase-mutant 성상세포종을 시사하는 영상 소견으로 알려져 있다. 이 증례 보고에서는 유방암 환자의 뇌에 생긴 점액성 뇌전이암이 T2-FLAIR mismatch sign처럼 보이는 사례를 소개한다. 특히 비조영증강 MRI에서 T2-FLAIR mismatch sign을 보이는 경우, 성상세포종 뿐만 아니라 뇌전이암을 감별진단에 염두에 두어야 한다.

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References

  1. Oshiro S, Tsugu H, Komatsu F, Abe H, Ohmura T, Sakamoto S, et al. Metastatic adenocarcinoma in the brain: magnetic resonance imaging with pathological correlations to mucin content. Anticancer Res 2008;28:407-413
  2. Patel SH, Poisson LM, Brat DJ, Zhou Y, Cooper L, Snuderl M, et al. T2-FLAIR mismatch, an imaging biomarker for IDH and 1p/19q status in lower-grade gliomas: a TCGA/TCIA project. Clin Cancer Res 2017;23:6078-6085 https://doi.org/10.1158/1078-0432.CCR-17-0560
  3. Carrier DA, Mawad ME, Kirkpatrick JB, Schmid MF. Metastatic adenocarcinoma to the brain: MR with pathologic correlation. AJNR Am J Neuroradiol 1994;15:155-159
  4. Onishi S, Amatya VJ, Kolakshyapati M, Takano M, Yonezawa U, Taguchi A, et al. T2-FLAIR mismatch sign in dysembryoplasticneuroepithelial tumor. Eur J Radiol 2020;126:108924
  5. Jain R, Johnson DR, Patel SH, Castillo M, Smits M, van den Bent MJ, et al. "Real world" use of a highly reliable imaging sign: "T2-FLAIR mismatch" for identification of IDH mutant astrocytomas. Neuro Oncol 2020;22:936-943 https://doi.org/10.1093/neuonc/noaa041
  6. Pinto C, Noronha C, Taipa R, Ramos C. T2-FLAIR mismatch sign: a roadmap of pearls and pitfalls. Br J Radiol 2022;95:20210825