Nuclear Engineering and Technology

Korean Nuclear Society (한국원자력학회)
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Dose absorption of Omicron variant SARS-CoV-2 by electron radiation: Using Geant4-DNA toolkit

  • Mehrdad Jalili Torkamani (Department of Physics, Faculty of Science, University of Mohaghegh Ardabili) ;
  • Chiman Karami (Department of Microbiology, Parasitology and Immunology, Ardabil University of Medical Sciences) ;
  • Pooneh Sayyah-Koohi (Department of Physics, Faculty of Science, University of Mohaghegh Ardabili) ;
  • Farhood Ziaie (Radiation Application Research School, Nuclear Science & Technology Research Institute) ;
  • Seyyedsina Moosavi (Department of Geology, Ferdowsi University of Mashhad) ;
  • Farhad Zolfagharpour (Department of Physics, Faculty of Science, University of Mohaghegh Ardabili)
  • Received : 2023.03.16
  • Accepted : 2024.01.31
  • Published : 2024.06.25
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Abstract

In this research, the Omicron variant of the SARS-CoV-2 virus was simulated and exposed to electron radiation with up to 20 keV energy. Absorbed energy was measured for spike protein, nucleocapsid protein, and envelope of the virus. Simulations were performed by Geant4-DNA in a water environment at temperature of 20 ℃ and pressure of 1 atm. Since the viral RNA is kept inside the nucleocapsid protein, damage to this area could destroy the viral RNA strand and create an inactive virus. Our findings showed that electron beams with an energy of 2.5 keV could cause a maximum absorption dose and consequently maximum damage to the nucleocapsid and effectively be used for inactivation virus.

Keywords

Acknowledgement

The authors would like to acknowledge staff of nuclear lab of University of Mohaghegh Ardabili to giving allow access to their computer and their intellectual cooperation in this study.

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