DOI QR코드

DOI QR Code

Age Distribution and Clinical Results of Critically Ill Patients above 65-Year-Old in an Aging Society: A Retrospective Cohort Study

  • Song I Lee (Division of Allergy, Pulmonary and Critical Care Medicine, Department of Internal Medicine, Chungnam National University Hospital, Chungnam National University College of Medicine) ;
  • Jin Won Huh (Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Sang-Bum Hong (Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Younsuck Koh (Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Chae-Man Lim (Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine)
  • 투고 : 2023.10.02
  • 심사 : 2024.02.27
  • 발행 : 2024.07.31

초록

Background: Increasing age has been observed among patients admitted to the intensive care unit (ICU). Age traditionally considered a risk factor for ICU mortality. We investigated how the epidemiology and clinical outcomes of older ICU patients have changed over a decade. Methods: We analyzed patients admitted to the ICU at a university hospital in Seoul, South Korea. We defined patients aged 65 and older as older patients. Changes in age groups and mortality risk factors over the study period were analyzed. Results: A total of 32,322 patients were enrolled who aged ≥65 years admitted to the ICUs between January 1, 2007, and December 31, 2017. Patients aged ≥65 years accounted for 35% and of these, the older (O, 65 to 74 years) comprised 19,630 (66.5%), very older (VO, 75 to 84 years) group 8,573 (29.1%), and very very older (VVO, ≥85 years) group 1,300 (4.4%). The mean age of ICU patients over the study period increased (71.9±5.6 years in 2007 vs. 73.2±6.1 years in 2017) and the proportions of the VO and VVO group both increased. Over the period, the proportion of female increased (37.9% in 2007 vs. 43.3% in 2017), and increased ICU admissions for medical reasons (39.7% in 2007 vs. 40.2% in 2017). In-hospital mortality declined across all older age groups, from 10.3% in 2007 to 7.6% in 2017. Hospital length of stay (LOS) decreased in all groups, but ICU LOS decreased only in the O and VO groups. Conclusion: The study indicates a changing demographic in ICUs with an increase in older patients, and suggests a need for customized ICU treatment strategies and resources.

키워드

과제정보

We appreciate the in-depth review of the statistical and methodological accuracy of this paper performed by the Academic Clinical Research Operating and Supporting System, Chungnam National University Hospital Biomedical Research Institute.

참고문헌

  1. Nguyen YL, Angus DC, Boumendil A, Guidet B. The challenge of admitting the very elderly to intensive care. Ann Intensive Care 2011;1:29. 
  2. Lutz W, Sanderson W, Scherbov S. The coming acceleration of global population ageing. Nature 2008;451:716-9. 
  3. World Health Organization. Ageing and health [Internet]. Geneva: WHO; 2022 [cited 2024 Mar 8]. Available from: https://www.who.int/news-room/fact-sheets/detail/ageing-and-health. 
  4. Statistics Korea. Average remaining life expectancy table [Internet]. Daejeon: Statistics Korea; 2017 [cited 2024 Mar 8]. Available from: https://www.index.go.kr/unity/potal/main.do. 
  5. Korean Statistical Information Service. Aging index [Internet]. Daejeon: Statistics Korea; 2023 [cited 2024 Mar 8]. Available from: https://kosis.kr/visual/nsportalStats/detailContents.do?statJipyoId=3646&vStatJipyoId=4883&listId=A. 
  6. Kim KW, Kim OS. Super aging in South Korea unstoppable but mitigatable: a sub-national scale population projection for best policy planning. Spat Demogr 2020;8:155-73. 
  7. de Rooij SE, Abu-Hanna A, Levi M, de Jonge E. Factors that predict outcome of intensive care treatment in very elderly patients: a review. Crit Care 2005;9:R307-14. 
  8. Flaatten H, de Lange DW, Artigas A, Bin D, Moreno R, Christensen S, et al. The status of intensive care medicine research and a future agenda for very old patients in the ICU. Intensive Care Med 2017;43:1319-28. 
  9. Al-Dorzi HM, Tamim HM, Mundekkadan S, Sohail MR, Arabi YM. Characteristics, management and outcomes of critically ill patients who are 80 years and older: a retrospective comparative cohort study. BMC Anesthesiol 2014;14:126. 
  10. Fuchs L, Chronaki CE, Park S, Novack V, Baumfeld Y, Scott D, et al. ICU admission characteristics and mortality rates among elderly and very elderly patients. Intensive Care Med 2012;38:1654-61. 
  11. Escourrou E, Laurent S, Leroux J, Oustric S, Gardette V. The shift from old age to very old age: an analysis of the perception of aging among older people. BMC Prim Care 2022;23:3. 
  12. Howlett SE, Rutenberg AD, Rockwood K. The degree of frailty as a translational measure of health in aging. Nat Aging 2021;1:651-65. 
  13. Gordon EH, Hubbard RE. Frailty: understanding the difference between age and ageing. Age Ageing 2022;51:afac185. 
  14. Vetrano DL, Palmer K, Marengoni A, Marzetti E, Lattanzio F, Roller-Wirnsberger R, et al. Frailty and multimorbidity: a systematic review and meta-analysis. J Gerontol A Biol Sci Med Sci 2019;74:659-66. 
  15. Tazzeo C, Rizzuto D, Calderon-Larranaga A, Roso-Llorach A, Marengoni A, Welmer AK, et al. Multimorbidity patterns and risk of frailty in older community-dwelling adults: a population-based cohort study. Age Ageing 2021;50:2183-91. 
  16. Rai S, Brace C, Ross P, Darvall J, Haines K, Mitchell I, et al. Characteristics and outcomes of very elderly patients admitted to intensive care: a retrospective multicenter cohort analysis. Crit Care Med 2023;51:1328-38. 
  17. Cobert J, Jeon SY, Boscardin J, Chapman AC, Ferrante LE, Lee S, et al. Trends in geriatric conditions among older adults admitted to US ICUs between 1998 and 2015. Chest 2022;161:1555-65. 
  18. Kim DY, Lee MH, Lee SY, Yang BR, Kim HA. Survival rates following medical intensive care unit admission from 2003 to 2013: an observational study based on a representative population-based sample cohort of Korean patients. Medicine (Baltimore) 2019;98:e17090. 
  19. Garland A, Olafson K, Ramsey CD, Yogendran M, Fransoo R. Epidemiology of critically ill patients in intensive care units: a population-based observational study. Crit Care 2013;17:R212. 
  20. Ihra GC, Lehberger J, Hochrieser H, Bauer P, Schmutz R, Metnitz B, et al. Development of demographics and outcome of very old critically ill patients admitted to intensive care units. Intensive Care Med 2012;38:620-6. 
  21. Haas LE, Karakus A, Holman R, Cihangir S, Reidinga AC, de Keizer NF. Trends in hospital and intensive care admissions in the Netherlands attributable to the very elderly in an ageing population. Crit Care 2015;19:353. 
  22. Laporte L, Hermetet C, Jouan Y, Gaborit C, Rouve E, Shea KM, et al. Ten-year trends in intensive care admissions for respiratory infections in the elderly. Ann Intensive Care 2018;8:84. 
  23. Ko RE, Kang D, Cho J, Na SJ, Chung CR, Lim SY, et al. Influence of gender on age-associated in-hospital mortality in patients with sepsis and septic shock: a prospective nationwide multicenter cohort study. Crit Care 2023;27:229. 
  24. Nair S, Sawant N, Thippeswamy H, Desai G. Gender issues in the care of elderly: a narrative review. Indian J Psychol Med 2021;43(5 Suppl):S48-52. 
  25. Fuchs L, Novack V, McLennan S, Celi LA, Baumfeld Y, Park S, et al. Trends in severity of illness on ICU admission and mortality among the elderly. PLoS One 2014;9:e93234. 
  26. Lerolle N, Trinquart L, Bornstain C, Tadie JM, Imbert A, Diehl JL, et al. Increased intensity of treatment and decreased mortality in elderly patients in an intensive care unit over a decade. Crit Care Med 2010;38:59-64. 
  27. Esteban A, Frutos-Vivar F, Muriel A, Ferguson ND, Penuelas O, Abraira V, et al. Evolution of mortality over time in patients receiving mechanical ventilation. Am J Respir Crit Care Med 2013;188:220-30. 
  28. Ten Haken I, Ben Allouch S, van Harten WH. The use of advanced medical technologies at home: a systematic review of the literature. BMC Public Health 2018;18:284. 
  29. Reynolds R, Dennis S, Hasan I, Slewa J, Chen W, Tian D, et al. A systematic review of chronic disease management interventions in primary care. BMC Fam Pract 2018;19:11. 
  30. Chang SY, Sevransky J, Martin GS. Protocols in the management of critical illness. Crit Care 2012;16:306. 
  31. Martinez-Velilla N, Cadore EL, Casas-Herrero A, Idoate-Saralegui F, Izquierdo M. Physical activity and early rehabilitation in hospitalized elderly medical patients: systematic review of randomized clinical trials. J Nutr Health Aging 2016;20:738-51. 
  32. Everink IH, van Haastregt JC, van Hoof SJ, Schols JM, Kempen GI. Factors influencing home discharge after inpatient rehabilitation of older patients: a systematic review. BMC Geriatr 2016;16:5. 
  33. Lesieur O, Herbland A, Cabasson S, Hoppe MA, Guillaume F, Leloup M. Changes in limitations of life-sustaining treatments over time in a French intensive care unit: a prospective observational study. J Crit Care 2018;47:21-9. 
  34. Williams TA, Dobb GJ, Finn JC, Webb SA. Long-term survival from intensive care: a review. Intensive Care Med 2005;31:1306-15. 
  35. Lim JU, Lee J, Ha JH, Kang HH, Lee SH, Moon HS. Demographic changes in intensive care units in Korea over the last decade and outcomes of elderly patients: a single-center retrospective study. Korean J Crit Care Med 2017;32:164-73. 
  36. Nam H, Cho JH, Choi EY, Chang Y, Choi WI, Hwang JJ, et al. Current status of noninvasive ventilation use in Korean intensive care units: a prospective multicenter observational study. Tuberc Respir Dis (Seoul) 2019;82:242-50. 
  37. Kim HI, Cho JH, Park SY, Lee YS, Chang Y, Choi WI, et al. Home mechanical ventilation use in South Korea based on national health insurance service data. Respir Care 2019;64:528-35. 
  38. Sprung CL, Artigas A, Kesecioglu J, Pezzi A, Wiis J, Pirracchio R, et al. The Eldicus prospective, observational study of triage decision making in European intensive care units. Part II: intensive care benefit for the elderly. Crit Care Med 2012;40:132-8. 
  39. Roch A, Wiramus S, Pauly V, Forel JM, Guervilly C, Gainnier M, et al. Long-term outcome in medical patients aged 80 or over following admission to an intensive care unit. Crit Care 2011;15:R36. 
  40. Reinikainen M, Uusaro A, Niskanen M, Ruokonen E. Intensive care of the elderly in Finland. Acta Anaesthesiol Scand 2007;51:522-9. 
  41. Boumendil A, Aegerter P, Guidet B; CUB-Rea Network. Treatment intensity and outcome of patients aged 80 and older in intensive care units: a multicenter matched-cohort study. J Am Geriatr Soc 2005;53:88-93. 
  42. Torres OH, Francia E, Longobardi V, Gich I, Benito S, Ruiz D. Short- and long-term outcomes of older patients in intermediate care units. Intensive Care Med 2006;32:1052-9. 
  43. Kaarlola A, Tallgren M, Pettila V. Long-term survival, quality of life, and quality-adjusted life-years among critically ill elderly patients. Crit Care Med 2006;34:2120-6. 
  44. Flaatten H, De Lange DW, Morandi A, Andersen FH, Artigas A, Bertolini G, et al. The impact of frailty on ICU and 30-day mortality and the level of care in very elderly patients (≥ 80 years). Intensive Care Med 2017;43:1820-8. 
  45. Guidet B, de Lange DW, Boumendil A, Leaver S, Watson X, Boulanger C, et al. The contribution of frailty, cognition, activity of daily life and comorbidities on outcome in acutely admitted patients over 80 years in European ICUs: the VIP2 study. Intensive Care Med 2020;46:57-69. 
  46. Abuhasira R, Anstey M, Novack V, Bose S, Talmor D, Fuchs L. Intensive care unit capacity and mortality in older adults: a three nations retrospective observational cohort study. Ann Intensive Care 2022;12:20. 
  47. Vallet H, Schwarz GL, Flaatten H, de Lange DW, Guidet B, Dechartres A. Mortality of older patients admitted to an ICU: a systematic review. Crit Care Med 2021;49:324-34. 
  48. Jung C, Wernly B, Muessig JM, Kelm M, Boumendil A, Morandi A, et al. A comparison of very old patients admitted to intensive care unit after acute versus elective surgery or intervention. J Crit Care 2019;52:141-8.