Nutrition Research and Practice

  • 제18권4호
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  • Pages.498-510
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  • 2024
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  • 1976-1457(pISSN)
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  • 2005-6168(eISSN)
한국영양학회 (The Korean Nutrition Society)
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Opuntia humifusa stems rich in quercetin and isorhamnetin alleviate insulin resistance in high-fat diet-fed rats

  • Young-Min Lee (Department of Practical Science Education, Gyeongin National University of Education) ;
  • Yeonjeong Choi (Department of Food and Nutrition, Gyeongsang National University) ;
  • Eunseo Kim (Department of Food and Nutrition, Gyeongsang National University) ;
  • In-Guk Hwang (Functional Food Division, National Institute of Agricultural Sciences, Rural Development Administration) ;
  • Yoona Kim (Department of Food and Nutrition, Institute of Agriculture and Life Science, Gyeongsang National University)
  • 투고 : 2024.01.29
  • 심사 : 2024.05.09
  • 발행 : 2024.08.01
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초록

BACKGROUND/OBJECTIVES: Obesity, characterized by abnormal fat accumulation and metabolic disturbances, presents a significant health challenge. Opuntia humifusa Raf., commonly known as Korean Cheonnyuncho, is rich in various beneficial compounds and has demonstrated antioxidant and anti-inflammatory effects. However, its potential impact on glucose and lipid metabolism, particularly in obese rats, remains unexplored. We aimed to investigate whether O. humifusa stems and fruits could beneficially alter glucose metabolism and lipid profiles in a rat model of high-fat diet (HFD)-induced obesity. MATERIALS/METHODS: Thirty-two rats were allocated into 4 groups: normal diet (NF), HFD control (HF), HFD treated with 2% O. humifusa stems (HF-OS), and HFD treated with 2% O. humifusa fruits (HF-OF). Experimental diets were administered for 6 weeks. At the end of the treatment, liver and fat tissues were isolated, and serum was collected for biochemical analysis. The major flavonoid from O. humifusa stems and fruits was identified and quantified. RESULTS: After 6 weeks of treatment, the serum fasting glucose concentration in the HF-OS group was significantly lower than that in the HF group. Serum fasting insulin concentrations in both HF-OS and HF-OF groups tended to be lower than those in the HF group, indicating a significant improvement in insulin sensitivity in the HF-OS group. Additionally, the HF-OS group exhibited a tendency towards the restoration of adiponectin levels to that of the NF group. CONCLUSION: The 2% O. humifusa stems contain abundant quercetin and isorhamnetin, which alter fasting blood glucose levels in rats fed a HFD, leading to a favorable improvement in insulin resistance.

키워드

과제정보

The authors would like to thank Minkyung Je, Kyeonghoon Kang, Gyeonghye Baek, and Jimin Jeong for their valuable contributions in obtaining samples after the animals were euthanized.

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