International Journal of Stem Cells

Korean Society for Stem Cell Research (한국줄기세포학회)
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Guidelines for Manufacturing and Application of Organoids: Brain

  • Received : 2024.04.24
  • Accepted : 2024.05.09
  • Published : 2024.05.30
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Abstract

This study offers a comprehensive overview of brain organoids for researchers. It combines expert opinions with technical summaries on organoid definitions, characteristics, culture methods, and quality control. This approach aims to enhance the utilization of brain organoids in research. Brain organoids, as three-dimensional human cell models mimicking the nervous system, hold immense promise for studying the human brain. They offer advantages over traditional methods, replicating anatomical structures, physiological features, and complex neuronal networks. Additionally, brain organoids can model nervous system development and interactions between cell types and the microenvironment. By providing a foundation for utilizing the most human-relevant tissue models, this work empowers researchers to overcome limitations of two-dimensional cultures and conduct advanced disease modeling research.

Keywords

Acknowledgement

This work was supported by a grant (23212MFDS265) from the Ministry of Food and Drug Safety in 2023.

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